CD79a molecule, immunoglobulin-associated alpha (CD79A) - coding DNA reference sequence

(used for mutation description)

(last modified May 1, 2014)

This file was created to facilitate the description of sequence variants in the CD79A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering CD79A transcript NM_001783.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.1005
                                                        tccac       c.-181

 .         .         .         .         .         .                g.1065
 tcacagcctgaagcatacccggcaggggctgtccccaggcccaacaagcaaagggcccag       c.-121

 .         .         .         .         .         .                g.1125
 tagcgagggccactggagcccatctccggggggctgggcaggaagtagggtggggtttgg       c.-61

 .         .         .         .         .         .                g.1185
 ggtagggatctggtaccctgggactgctgcaactcaaactaaccaacccactgggagaag       c.-1

          .         .         .         .         .         .       g.1245
 ATGCCTGGGGGTCCAGGAGTCCTCCAAGCTCTGCCTGCCACCATCTTCCTCCTCTTCCTG       c.60
 M  P  G  G  P  G  V  L  Q  A  L  P  A  T  I  F  L  L  F  L         p.20

          .          | 02        .         .         .         .    g.2911
 CTGTCTGCTGTCTACCTGG | GCCCTGGGTGCCAGGCCCTGTGGATGCACAAGGTCCCAGCA    c.120
 L  S  A  V  Y  L  G |   P  G  C  Q  A  L  W  M  H  K  V  P  A      p.40

          .         .         .         .         .         .       g.2971
 TCATTGATGGTGAGCCTGGGGGAAGACGCCCACTTCCAATGCCCGCACAATAGCAGCAAC       c.180
 S  L  M  V  S  L  G  E  D  A  H  F  Q  C  P  H  N  S  S  N         p.60

          .         .         .         .         .         .       g.3031
 AACGCCAACGTCACCTGGTGGCGCGTCCTCCATGGCAACTACACGTGGCCCCCTGAGTTC       c.240
 N  A  N  V  T  W  W  R  V  L  H  G  N  Y  T  W  P  P  E  F         p.80

          .         .         .         .         .         .       g.3091
 TTGGGCCCGGGCGAGGACCCCAATGGTACGCTGATCATCCAGAATGTGAACAAGAGCCAT       c.300
 L  G  P  G  E  D  P  N  G  T  L  I  I  Q  N  V  N  K  S  H         p.100

          .         .         .         .         .         .       g.3151
 GGGGGCATATACGTGTGCCGGGTCCAGGAGGGCAACGAGTCATACCAGCAGTCCTGCGGC       c.360
 G  G  I  Y  V  C  R  V  Q  E  G  N  E  S  Y  Q  Q  S  C  G         p.120

          .          | 03        .         .         .         .    g.3456
 ACCTACCTCCGCGTGCGCC | AGCCGCCCCCCAGGCCCTTCCTGGACATGGGGGAGGGCACC    c.420
 T  Y  L  R  V  R  Q |   P  P  P  R  P  F  L  D  M  G  E  G  T      p.140

          .         .         .         .         .         .       g.3516
 AAGAACCGAATCATCACAGCCGAGGGGATCATCCTCCTGTTCTGCGCGGTGGTGCCTGGG       c.480
 K  N  R  I  I  T  A  E  G  I  I  L  L  F  C  A  V  V  P  G         p.160

          .         | 04         .         .         .         .    g.4589
 ACGCTGCTGCTGTTCAGG | AAACGATGGCAGAACGAGAAGCTCGGGTTGGATGCCGGGGAT    c.540
 T  L  L  L  F  R   | K  R  W  Q  N  E  K  L  G  L  D  A  G  D      p.180

          .         .        | 05.         .         .         .    g.4777
 GAATATGAAGATGAAAACCTTTATGAA | GGCCTGAACCTGGACGACTGCTCCATGTATGAG    c.600
 E  Y  E  D  E  N  L  Y  E   | G  L  N  L  D  D  C  S  M  Y  E      p.200

          .         .         .         .         .         .       g.4837
 GACATCTCCCGGGGCCTCCAGGGCACCTACCAGGATGTGGGCAGCCTCAACATAGGAGAT       c.660
 D  I  S  R  G  L  Q  G  T  Y  Q  D  V  G  S  L  N  I  G  D         p.220

          .         .                                               g.4858
 GTCCAGCTGGAGAAGCCGTGA                                              c.681
 V  Q  L  E  K  P  X                                                p.226

          .         .         .         .         .         .       g.4918
 cacccctactcctgccaggctgcccccgcctgctgtgcacccagctccagtgtctcagct       c.*60

          .         .         .         .         .         .       g.4978
 cacttccctgggacattctcctttcagcccttctgggggcttccttagtcatattccccc       c.*120

          .         .         .         .         .         .       g.5038
 agtggggggtgggagggtaacctcactcttctccaggccaggcctccttggactcccctg       c.*180

          .         .         .         .         .         .       g.5098
 ggggtgtcccactcttcttccctctaaactgccccacctcctaacctaatccccccgccc       c.*240

          .         .         .         .         .         .       g.5158
 cgctgcctttcccaggctcccctcaccccagcgggtaatgagcccttaatcgctgcctct       c.*300

          .         .         .         .         .         .       g.5218
 aggggagctgattgtagcagcctcgttagtgtcaccccctcctccctgatctgtcagggc       c.*360

          .         .         .                                     g.5250
 cacttagtgataataaattcttcccaactgca                                   c.*392

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The CD79a molecule, immunoglobulin-associated alpha protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.