Fc fragment of IgG, low affinity IIa, receptor (CD32) (FCGR2A) - coding DNA reference sequence

(used for mutation description)

(last modified May 1, 2014)

This file was created to facilitate the description of sequence variants in the FCGR2A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering FCGR2A transcript NM_021642.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
           .         .         .         .         .                g.1053
        ctcttttctaagcttgtctcttaaaacccactggacgttggcacagtgctggg       c.-1

          .         .         .         .         .         .       g.1113
 ATGACTATGGAGACCCAAATGTCTCAGAATGTATGTCCCAGAAACCTGTGGCTGCTTCAA       c.60
 M  T  M  E  T  Q  M  S  Q  N  V  C  P  R  N  L  W  L  L  Q         p.20

          .         .      | 02  .         .       | 03 .         . g.1936
 CCATTGACAGTTTTGCTGCTGCTGG | CTTCTGCAGACAGTCAAGCTG | CTCCCCCAAAGGCT c.120
 P  L  T  V  L  L  L  L  A |   S  A  D  S  Q  A  A |   P  P  K  A   p.40

          .         .         .         .         .         .       g.1996
 GTGCTGAAACTTGAGCCCCCGTGGATCAACGTGCTCCAGGAGGACTCTGTGACTCTGACA       c.180
 V  L  K  L  E  P  P  W  I  N  V  L  Q  E  D  S  V  T  L  T         p.60

          .         .         .         .         .         .       g.2056
 TGCCAGGGGGCTCGCAGCCCTGAGAGCGACTCCATTCAGTGGTTCCACAATGGGAATCTC       c.240
 C  Q  G  A  R  S  P  E  S  D  S  I  Q  W  F  H  N  G  N  L         p.80

          .         .         .         .         .         .       g.2116
 ATTCCCACCCACACGCAGCCCAGCTACAGGTTCAAGGCCAACAACAATGACAGCGGGGAG       c.300
 I  P  T  H  T  Q  P  S  Y  R  F  K  A  N  N  N  D  S  G  E         p.100

          .         .         .         .         .         .       g.2176
 TACACGTGCCAGACTGGCCAGACCAGCCTCAGCGACCCTGTGCATCTGACTGTGCTTTCC       c.360
 Y  T  C  Q  T  G  Q  T  S  L  S  D  P  V  H  L  T  V  L  S         p.120

   | 04      .         .         .         .         .         .    g.5464
 G | AATGGCTGGTGCTCCAGACCCCTCACCTGGAGTTCCAGGAGGGAGAAACCATCATGCTG    c.420
 E |   W  L  V  L  Q  T  P  H  L  E  F  Q  E  G  E  T  I  M  L      p.140

          .         .         .         .         .         .       g.5524
 AGGTGCCACAGCTGGAAGGACAAGCCTCTGGTCAAGGTCACATTCTTCCAGAATGGAAAA       c.480
 R  C  H  S  W  K  D  K  P  L  V  K  V  T  F  F  Q  N  G  K         p.160

          .         .         .         .         .         .       g.5584
 TCCCAGAAATTCTCCCATTTGGATCCCACCTTCTCCATCCCACAAGCAAACCACAGTCAC       c.540
 S  Q  K  F  S  H  L  D  P  T  F  S  I  P  Q  A  N  H  S  H         p.180

          .         .         .         .         .         .       g.5644
 AGTGGTGATTACCACTGCACAGGAAACATAGGCTACACGCTGTTCTCATCCAAGCCTGTG       c.600
 S  G  D  Y  H  C  T  G  N  I  G  Y  T  L  F  S  S  K  P  V         p.200

          .       | 05 .         .         .         .         .    g.6463
 ACCATCACTGTCCAAG | TGCCCAGCATGGGCAGCTCTTCACCAATGGGGATCATTGTGGCT    c.660
 T  I  T  V  Q  V |   P  S  M  G  S  S  S  P  M  G  I  I  V  A      p.220

          .         .         .         .         .         .       g.6523
 GTGGTCATTGCGACTGCTGTAGCAGCCATTGTTGCTGCTGTAGTGGCCTTGATCTACTGC       c.720
 V  V  I  A  T  A  V  A  A  I  V  A  A  V  V  A  L  I  Y  C         p.240

          .          | 06        .         .         .        | 07. g.13563
 AGGAAAAAGCGGATTTCAG | CCAATTCCACTGATCCTGTGAAGGCTGCCCAATTTGAG | CCA c.780
 R  K  K  R  I  S  A |   N  S  T  D  P  V  K  A  A  Q  F  E   | P   p.260

          .         .         .         .         .         .       g.13623
 CCTGGACGTCAAATGATTGCCATCAGAAAGAGACAACTTGAAGAAACCAACAATGACTAT       c.840
 P  G  R  Q  M  I  A  I  R  K  R  Q  L  E  E  T  N  N  D  Y         p.280

          .         .         .         .         .         .       g.13683
 GAAACAGCTGACGGCGGCTACATGACTCTGAACCCCAGGGCACCTACTGACGATGATAAA       c.900
 E  T  A  D  G  G  Y  M  T  L  N  P  R  A  P  T  D  D  D  K         p.300

          .         .         .         .         .                 g.13734
 AACATCTACCTGACTCTTCCTCCCAACGACCATGTCAACAGTAATAACTAA                c.951
 N  I  Y  L  T  L  P  P  N  D  H  V  N  S  N  N  X                  p.316

          .         .         .         .         .         .       g.13794
 agagtaacgttatgccatgtggtcatactctcagcttgctgagtggatgacaaaaagagg       c.*60

          .         .         .         .         .         .       g.13854
 ggaattgttaaaggaaaatttaaatggagactggaaaaatcctgagcaaacaaaaccacc       c.*120

          .         .         .         .         .         .       g.13914
 tggcccttagaaatagctttaactttgcttaaactacaaacacaagcaaaacttcacggg       c.*180

          .         .         .         .         .         .       g.13974
 gtcatactacatacaagcataagcaaaacttaacttggatcatttctggtaaatgcttat       c.*240

          .         .         .         .         .         .       g.14034
 gttagaaataagacaaccccagccaatcacaagcagcctactaacatataattaggtgac       c.*300

          .         .         .         .         .         .       g.14094
 tagggactttctaagaagatacctacccccaaaaaacaattatgtaattgaaaaccaacc       c.*360

          .         .         .         .         .         .       g.14154
 gattgcctttattttgcttccacattttcccaataaatacttgcctgtgacattttgcca       c.*420

          .         .         .         .         .         .       g.14214
 ctggaacactaaacttcatgaattgcgcctcagatttttcctttaacatctttttttttt       c.*480

          .         .         .         .         .         .       g.14274
 ttgacagagtctcaatctgttacccaggctggagtgcagtggtgctatcttggctcactg       c.*540

          .         .         .         .         .         .       g.14334
 caaacccgcctcccaggtttaagcgattctcatgcctcagcctcccagtagctgggatta       c.*600

          .         .         .         .         .         .       g.14394
 gaggcatgtgccatcatacccagctaatttttgtattttttattttttttttttagtaga       c.*660

          .         .         .         .         .         .       g.14454
 gacagggtttcgcaatgttggccaggccgatctcgaacttctggcctctagcgatctgcc       c.*720

          .         .         .         .         .         .       g.14514
 cgcctcggcctcccaaagtgctgggatgaccagcatcagccccaatgtccagcctcttta       c.*780

          .         .         .         .         .         .       g.14574
 acatcttctttcctatgccctctctgtggatccctactgctggtttctgccttctccatg       c.*840

          .         .         .         .         .         .       g.14634
 ctgagaacaaaatcacctattcactgcttatgcagtcggaagctccagaagaacaaagag       c.*900

          .         .         .         .         .         .       g.14694
 cccaattaccagaaccacattaagtctccattgttttgccttgggatttgagaagagaat       c.*960

          .         .         .         .         .         .       g.14754
 tagagaggtgaggatctggtatttcctggactaaattccccttggggaagacgaagggat       c.*1020

          .         .         .         .         .         .       g.14814
 gctgcagttccaaaagagaaggactcttccagagtcatctacctgagtcccaaagctccc       c.*1080

          .         .         .         .         .         .       g.14874
 tgtcctgaaagccacagacaatatggtcccaaatgactgactgcaccttctgtgcctcag       c.*1140

          .         .         .         .         .         .       g.14934
 ccgttcttgacatcaagaatcttctgttccacatccacacagccaatacaattagtcaaa       c.*1200

          .         .         .         .         .         .       g.14994
 ccactgttattaacagatgtagcaacatgagaaacgcttatgttacaggttacatgagag       c.*1260

          .         .         .         .         .         .       g.15054
 caatcatgtaagtctatatgacttcagaaatgttaaaatagactaacctctaacaacaaa       c.*1320

          .         .         .         .         .         .       g.15114
 ttaaaagtgattgtttcaaggtgatgcaattattgatgacctattttatttttctataat       c.*1380

          .         .         .         .                           g.15156
 gatcatatattacctttgtaataaaacattataaccaaaaca                         c.*1422

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Fc fragment of IgG, low affinity IIa, receptor (CD32) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.