interleukin 10 receptor, beta (IL10RB) - coding DNA reference sequence

(used for mutation description)

(last modified April 30, 2014)

This file was created to facilitate the description of sequence variants in the IL10RB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000021.8, covering IL10RB transcript NM_000628.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.1046
               cccgcccatctccgctggttcccggaagccgccgcggacaagctct       c.-61

 .         .         .         .         .         .                g.1106
 cccgggcgcgggcgggggtcgtgtgcttggaggaagccgcggaacccccagcgtccgtcc       c.-1

          .         .         .         .          | 02        .    g.3045
 ATGGCGTGGAGCCTTGGGAGCTGGCTGGGTGGCTGCCTGCTGGTGTCAG | CATTGGGAATG    c.60
 M  A  W  S  L  G  S  W  L  G  G  C  L  L  V  S  A |   L  G  M      p.20

          .         .         .         .         .         .       g.3105
 GTACCACCTCCCGAAAATGTCAGAATGAATTCTGTTAATTTCAAGAACATTCTACAGTGG       c.120
 V  P  P  P  E  N  V  R  M  N  S  V  N  F  K  N  I  L  Q  W         p.40

          .         .         .         .         .    | 03    .    g.11243
 GAGTCACCTGCTTTTGCCAAAGGGAACCTGACTTTCACAGCTCAGTACCTAAG | TTATAGG    c.180
 E  S  P  A  F  A  K  G  N  L  T  F  T  A  Q  Y  L  S  |  Y  R      p.60

          .         .         .         .         .         .       g.11303
 ATATTCCAAGATAAATGCATGAATACTACCTTGACGGAATGTGATTTCTCAAGTCTTTCC       c.240
 I  F  Q  D  K  C  M  N  T  T  L  T  E  C  D  F  S  S  L  S         p.80

          .         .         .         .         .         .       g.11363
 AAGTATGGTGACCACACCTTGAGAGTCAGGGCTGAATTTGCAGATGAGCATTCAGACTGG       c.300
 K  Y  G  D  H  T  L  R  V  R  A  E  F  A  D  E  H  S  D  W         p.100

          .         .         .  | 04      .         .         .    g.14421
 GTAAACATCACCTTCTGTCCTGTGGATGACA | CCATTATTGGACCCCCTGGAATGCAAGTA    c.360
 V  N  I  T  F  C  P  V  D  D  T |   I  I  G  P  P  G  M  Q  V      p.120

          .         .         .         .         .         .       g.14481
 GAAGTACTTGCTGATTCTTTACATATGCGTTTCTTAGCCCCTAAAATTGAGAATGAATAC       c.420
 E  V  L  A  D  S  L  H  M  R  F  L  A  P  K  I  E  N  E  Y         p.140

          .         .         .         .         .         .       g.14541
 GAAACTTGGACTATGAAGAATGTGTATAACTCATGGACTTATAATGTGCAATACTGGAAA       c.480
 E  T  W  T  M  K  N  V  Y  N  S  W  T  Y  N  V  Q  Y  W  K         p.160

          .         | 05         .         .         .         .    g.17776
 AACGGTACTGATGAAAAG | TTTCAAATTACTCCCCAGTATGACTTTGAGGTCCTCAGAAAC    c.540
 N  G  T  D  E  K   | F  Q  I  T  P  Q  Y  D  F  E  V  L  R  N      p.180

          .         .         .         .         .         .       g.17836
 CTGGAGCCATGGACAACTTATTGTGTTCAAGTTCGAGGGTTTCTTCCTGATCGGAACAAA       c.600
 L  E  P  W  T  T  Y  C  V  Q  V  R  G  F  L  P  D  R  N  K         p.200

          .         .         .         .       | 06 .         .    g.22758
 GCTGGGGAATGGAGTGAGCCTGTCTGTGAGCAAACAACCCATGACG | AAACGGTCCCCTCC    c.660
 A  G  E  W  S  E  P  V  C  E  Q  T  T  H  D  E |   T  V  P  S      p.220

          .         .         .         .         .         .       g.22818
 TGGATGGTGGCCGTCATCCTCATGGCCTCGGTCTTCATGGTCTGCCTGGCACTCCTCGGC       c.720
 W  M  V  A  V  I  L  M  A  S  V  F  M  V  C  L  A  L  L  G         p.240

          .         .         .         .         .         .       g.22878
 TGCTTCGCCTTGCTGTGGTGCGTTTACAAGAAGACAAAGTACGCCTTCTCCCCTAGGAAT       c.780
 C  F  A  L  L  W  C  V  Y  K  K  T  K  Y  A  F  S  P  R  N         p.260

          .         .     | 07   .         .         .         .    g.30860
 TCTCTTCCACAGCACCTGAAAGAG | TTTTTGGGCCATCCTCATCATAACACACTTCTGTTT    c.840
 S  L  P  Q  H  L  K  E   | F  L  G  H  P  H  H  N  T  L  L  F      p.280

          .         .         .         .         .         .       g.30920
 TTCTCCTTTCCATTGTCGGATGAGAATGATGTTTTTGACAAGCTAAGTGTCATTGCAGAA       c.900
 F  S  F  P  L  S  D  E  N  D  V  F  D  K  L  S  V  I  A  E         p.300

          .         .         .         .         .         .       g.30980
 GACTCTGAGAGCGGCAAGCAGAATCCTGGTGACAGCTGCAGCCTCGGGACCCCGCCTGGG       c.960
 D  S  E  S  G  K  Q  N  P  G  D  S  C  S  L  G  T  P  P  G         p.320

          .                                                         g.30998
 CAGGGGCCCCAAAGCTAG                                                 c.978
 Q  G  P  Q  S  X                                                   p.325

          .         .         .         .         .         .       g.31058
 gctctgagaaggaaacacactcggctgggcacagtgacgtactccatctcacatctgcct       c.*60

          .         .         .         .         .         .       g.31118
 cagtgagggatcagggcagcaaacaagggccaagaccatctgagccagccccacatctag       c.*120

          .         .         .         .         .         .       g.31178
 aactcccagaccctggacttagccaccagagagctacattttaaaggctgtcttggcaaa       c.*180

          .         .         .         .         .         .       g.31238
 aatactccatttgggaactcactgccttataaaggctttcatgatgttttcagaagttgg       c.*240

          .         .         .         .         .         .       g.31298
 ccactgagagtgtaattttcagccttttatatcactaaaataagatcatgttttaattgt       c.*300

          .         .         .         .         .         .       g.31358
 gagaaacagggccgagcacagtggctcacgcctgtaataccagcaccttagaggtcgagg       c.*360

          .         .         .         .         .         .       g.31418
 caggcggatcacttgaggtcaggagttcaagaccagcctggccaatatggtgaaacccag       c.*420

          .         .         .         .         .         .       g.31478
 tctctactaaaaatacaaaaattagctaggcatgatggcgcatgcctataatcccagcta       c.*480

          .         .         .         .         .         .       g.31538
 ctcgagtgcctgaggcaggagaattgcatgaacccgggaggaggaggaggaggttgcagt       c.*540

          .         .         .         .         .         .       g.31598
 gagccgagatagcggcactgcactccagcctgggtgacaaagtgagactccatctcaaaa       c.*600

          .         .         .         .         .         .       g.31658
 aaaaaaaaaaaaaaaattgtgagaaacagaaatacttaaaatgaggaataagaatggaga       c.*660

          .         .         .         .         .         .       g.31718
 tgttacatctggtagatgtaacattctaccagattatggatggactgatctgaaaatcga       c.*720

          .         .         .         .         .         .       g.31778
 cctcaactcaagggtggtcagctcaatgctacacagagcacggacttttggattctttgc       c.*780

          .         .         .         .         .         .       g.31838
 agtactttgaatttatttttctacctatatatgttttatatgctgctggtgctccattaa       c.*840

          .         .         .                                     g.31875
 agttttactctgtgttgcactatatgtgttcatgata                              c.*877

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Interleukin 10 receptor, beta protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.