interleukin 1 receptor antagonist (IL1RN) - coding DNA reference sequence

(used for mutation description)

(last modified May 2, 2014)

This file was created to facilitate the description of sequence variants in the IL1RN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering IL1RN transcript NM_173841.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.7783
                                                       gggcag       c.-121

 .         .         .         .         .         .                g.7843
 ctccaccctgggagggactgtggcccaggtactgcccgggtgctactttatgggcagcag       c.-61

 .         .         .         .         .         .                g.7903
 ctcagttgagttagagtctggaagacctcagaagacctcctgtcctatgaggccctcccc       c.-1

          . | 02       .         .         .         .         .    g.10000
 ATGGCTTTAG | CTGACTTGTATGAAGAAGGAGGTGGAGGAGGAGGAGAAGGTGAAGACAAT    c.60
 M  A  L  A |   D  L  Y  E  E  G  G  G  G  G  G  E  G  E  D  N      p.20

          .    | 03    .         .         .         .         .    g.17620
 GCTGACTCAAAGG | AGACGATCTGCCGACCCTCTGGGAGAAAATCCAGCAAGATGCAAGCC    c.120
 A  D  S  K  E |   T  I  C  R  P  S  G  R  K  S  S  K  M  Q  A      p.40

       | 04  .         .         .         .         .         .    g.19515
 TTCAG | AATCTGGGATGTTAACCAGAAGACCTTCTATCTGAGGAACAACCAACTAGTTGCT    c.180
 F  R  |  I  W  D  V  N  Q  K  T  F  Y  L  R  N  N  Q  L  V  A      p.60

          .         .         .     | 05   .         .         .    g.20955
 GGATACTTGCAAGGACCAAATGTCAATTTAGAAG | AAAAGATAGATGTGGTACCCATTGAG    c.240
 G  Y  L  Q  G  P  N  V  N  L  E  E |   K  I  D  V  V  P  I  E      p.80

          .         .         .         .         .         .       g.21015
 CCTCATGCTCTGTTCTTGGGAATCCATGGAGGGAAGATGTGCCTGTCCTGTGTCAAGTCT       c.300
 P  H  A  L  F  L  G  I  H  G  G  K  M  C  L  S  C  V  K  S         p.100

          .         .        | 06.         .         .         .    g.22573
 GGTGATGAGACCAGACTCCAGCTGGAG | GCAGTTAACATCACTGACCTGAGCGAGAACAGA    c.360
 G  D  E  T  R  L  Q  L  E   | A  V  N  I  T  D  L  S  E  N  R      p.120

          .         .         .         .         .         .       g.22633
 AAGCAGGACAAGCGCTTCGCCTTCATCCGCTCAGACAGTGGCCCCACCACCAGTTTTGAG       c.420
 K  Q  D  K  R  F  A  F  I  R  S  D  S  G  P  T  T  S  F  E         p.140

          .         .         .         .         .         .       g.22693
 TCTGCCGCCTGCCCCGGTTGGTTCCTCTGCACAGCGATGGAAGCTGACCAGCCCGTCAGC       c.480
 S  A  A  C  P  G  W  F  L  C  T  A  M  E  A  D  Q  P  V  S         p.160

          .         .         .         .         .         .       g.22753
 CTCACCAATATGCCTGACGAAGGCGTCATGGTCACCAAATTCTACTTCCAGGAGGACGAG       c.540
 L  T  N  M  P  D  E  G  V  M  V  T  K  F  Y  F  Q  E  D  E         p.180

                                                                    g.22756
 TAG                                                                c.543
 X                                                                  p.180

          .         .         .         .         .         .       g.22816
 tactgcccaggcctgcctgttcccattcttgcatggcaaggactgcagggactgccagtc       c.*60

          .         .         .         .         .         .       g.22876
 cccctgccccagggctcccggctatgggggcactgaggaccagccattgaggggtggacc       c.*120

          .         .         .         .         .         .       g.22936
 ctcagaaggcgtcacaacaacctggtcacaggactctgcctcctcttcaactgaccagcc       c.*180

          .         .         .         .         .         .       g.22996
 tccatgctgcctccagaatggtctttctaatgtgtgaatcagagcacagcagcccctgca       c.*240

          .         .         .         .         .         .       g.23056
 caaagcccttccatgtcgcctctgcattcaggatcaaaccccgaccacctgcccaacctg       c.*300

          .         .         .         .         .         .       g.23116
 ctctcctcttgccactgcctcttcctccctcattccaccttcccatgccctggatccatc       c.*360

          .         .         .         .         .         .       g.23176
 aggccacttgatgacccccaaccaagtggctcccacaccctgttttacaaaaaagaaaag       c.*420

          .         .         .         .         .         .       g.23236
 accagtccatgagggaggtttttaagggtttgtggaaaatgaaaattaggatttcatgat       c.*480

          .         .         .         .         .         .       g.23296
 ttttttttttcagtccccgtgaaggagagcccttcatttggagattatgttctttcgggg       c.*540

          .         .         .         .         .         .       g.23356
 agaggctgaggacttaaaatattcctgcatttgtgaaatgatggtgaaagtaagtggtag       c.*600

          .         .         .         .         .         .       g.23416
 cttttcccttctttttcttctttttttgtgatgtcccaacttgtaaaaattaaaagttat       c.*660

          .         .         .         .         .         .       g.23476
 ggtactatgttagccccataattttttttttccttttaaaacacttccataatctggact       c.*720

          .         .         .         .         .         .       g.23536
 cctctgtccaggcactgctgcccagcctccaagctccatctccactccagattttttaca       c.*780

          .         .         .         .         .         .       g.23596
 gctgcctgcagtactttacctcctatcagaagtttctcagctcccaaggctctgagcaaa       c.*840

          .         .         .         .         .         .       g.23656
 tgtggctcctgggggttctttcttcctctgctgaaggaataaattgctccttgacattgt       c.*900

          .         .         .         .         .         .       g.23716
 agagcttctggcacttggagacttgtatgaaagatggctgtgcctctgcctgtctccccc       c.*960

          .         .         .         .         .         .       g.23776
 accgggctgggagctctgcagagcaggaaacatgactcgtatatgtctcaggtccctgca       c.*1020

          .         .         .         .         .         .       g.23836
 gggccaagcacctagcctcgctcttggcaggtactcagcgaatgaatgctgtatatgttg       c.*1080

          .         .         .         .         .         .       g.23896
 ggtgcaaagttccctacttcctgtgacttcagctctgttttacaataaaatcttgaaaat       c.*1140

                                                                    g.23901
 gccta                                                              c.*1145

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Interleukin 1 receptor antagonist protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.