MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A) - coding DNA reference sequence

(used for mutation description)

(last modified May 1, 2014)

This file was created to facilitate the description of sequence variants in the MRE11A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering MRE11A transcript NM_005591.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.9
 CTCACTTGA                                                          c.9
 L  T  X                                                            p.2

          .         .         .         .         .         .       g.69
 ttcaaaatcaacccctttcgatacttgactctgggacatgattttgctggatgatgtgct       c.*60

         | 02.         .         .         .         .         .    g.5974
 ggaccac | ctttgatctgtctttgaagtggtaggaaaaatgtcttcttccacatctgattc    c.*120

          .      | 03  .         .         .         .         .    g.7311
 atctacctcaatcac | ctctgaataattcttagtagtgacatttcgggaaggctgctgtct    c.*180

          .     | 04   .         .         .         .         .    g.15945
 tgtagatttaaagg | catctataatagacatatttctagatgctgacacagcagtctttga    c.*240

          .         .         .         | 05         .         .    g.17330
 gttcctgctacgggtagaagtctccagaccagtgtctg | ctcttcctctttgagaccctcc    c.*300

          .         .         .         .         .         .       g.17390
 tctcgatgctgaattctgccctcttccacctcttcgacctcttcctcggcctcttccttt       c.*360

          .         .         .         .         .         .       g.17450
 gttggttgctgctgagatgctatcatcagagtcattagccatctgttctgctaaatctat       c.*420

          .         .         .         .         .         .       g.17510
 actcataaggtcatcagcactaaaggcagaagcagactcctctgactgagatctgagtgc       c.*480

          .         | 06         .         .         .         .    g.26407
 tctggccctggtcatagc | ctcacggacttcatcatcttcttcattagtatttttttgtct    c.*540

          .         .  | 07      .         .         .         .    g.29536
 ggtttctctgaaacgacgtac | ctcctcatcgattttgtcttcgagggcatcaatatgacg    c.*600

          .         .         .         .         .         .       g.29596
 ttctttaagaaatcgctgtgttttttccaactggtatttcactaattcctcaatggcatc       c.*660

          .         .         .         .         .         .       g.29656
 tttctcctccttgtccacaaattcttgtactgcttcacccatccctctttctgttagcag       c.*720

          .      | 08  .         .         .         .         .    g.31070
 tgagagctgcacatt | cttctctgcggtttgaaagtactgttttacaagatcttctaccct    c.*780

          .         .         .         .         .       | 09 .    g.34206
 taaagttgttccttctgaaggctttgtgataagtttcccaaagttgatctcttctc | ctgt    c.*840

          .         .         .         .         .         .       g.34266
 tttttccttttgttctctatgcctgaaaaaatggataatgtcttttggattagctacccg       c.*900

          .         .         .         .         .         .       g.34326
 atccacaaatttctggctaaagcgaagaacactgaaaggttcaaaacctccactatagtc       c.*960

     | 10    .         .         .         .         .         .    g.37959
 cac | tcgcagtcgtacaagaggcttctctggctggtgagaattacccagacgttcccgttc    c.*1020

          .         .     | 11   .         .         .         .    g.40596
 agcattttcaagcatttcttcaat | cttctccaaacagaagctttgtatggcttgggttac    c.*1080

          .         .         .         .         .         .       g.40656
 tttaggattatctgggttaaaaatgtctggatgattagctagaacaatatcctccatgaa       c.*1140

          .         .         .         .         .         .       g.40716
 aaactgccgcactgtgtgaagaggaattttatgcatattcatcttcctccctttaatacg       c.*1200

          .       | 12 .         .         .         .         .    g.41707
 cagcaaaccaacatgt | ttctttacagcttctcctggggaaagagaagtaaccactgagct    c.*1260

          .         .         .         .         .         .       g.41767
 tccaggttgtgagatataaaacagctgttgttcatttttggttggagctattttacactc       c.*1320

          .         .         .         .         .         .       g.41827
 atgttcatggccccagataacaagatcaatgaagtcatccaaaaattgttctggaatgaa       c.*1380

          .         .   | 13     .         .         .         .    g.46416
 gttagtacttccatgtttactc | ctgttctgatgaatcacaaataagttaaaccaagagtt    c.*1440

          .         .         .         .         .         .       g.46476
 ctcatcttcctttggtctcaacattgttacttttttattgacaaacattcgatagagcct       c.*1500

          .        | 14.         .         .         .         .    g.48867
 ttcatctggaatggatc | ctaaaccatatagcgcaatctttgtgcttcctttttgaagcaa    c.*1560

          .         .         .         .         .         .       g.48927
 aaccggactaatgtctatcttctccacagacattgaacgtccaaagtgatttacaaatcc       c.*1620

          .         .         .          | 15        .         .    g.49784
 agcacaacttaaaatgtccaaggcacaaagtgcatctgc | ccctgtgggatcgtcatgatt    c.*1680

          .         .         .         .         .         .       g.49844
 gccatgaatactaaacactggaattgaaatgttgaggttgccatcttgatagttcaccca       c.*1740

         | 16.         .         .         .         .         .    g.56066
 tggaaac | ttactaaaaccaaagttgactgactgatcactgagaatttcaaactggacagg    c.*1800

          .         .         .         .         .         .       g.56126
 ccgatcacccatacaatattttcttaataactcgaggcaggtatgtaatgttttccttga       c.*1860

          .         .         .         .         | 17         .    g.60934
 gggcttattttcatgaaaaagatcaccacctaacaaaataaaatccac | ttcattttcctg    c.*1920

          .         .         .         .         .         .       g.60994
 ggcaagtcttaaaatttcatcgagtgttacaaacgtatcatttcctctgactgcatcttt       c.*1980

          .         .         .         .         .         .       g.61054
 ctccataaatccaagatgaatatctgttgcaactaatattttaaatgtgttttcatcatc       c.*2040

   | 18      .         .         .         .         .         .    g.62930
 a | agtgcatctgcagtactcatttttatggtcagtcaagctcctctgggaccaggttcttc    c.*2100

          .         .         .         .         .         .       g.62990
 tccaagaacccctgggtactgtactcaaatgtcagaaaatgcactcgattccaaattcta       c.*2160

        | 19 .         .         .         .         .         .    g.63934
 gaaatt | ctctgagaacccgcagggccgtaaacctgaattccgcgggagagaacggcgtcc    c.*2220

          .         .         . | 20       .         .         .                                 g.63994
 gtttctctcgcgacacttcatggataacgt | a                                 c.*2251

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The MRE11 meiotic recombination 11 homolog A (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.