myeloid differentiation primary response 88 (MYD88) - coding DNA reference sequence

(used for mutation description)

(last modified May 1, 2014)

This file was created to facilitate the description of sequence variants in the MYD88 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering MYD88 transcript NM_002468.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.1004
                                                         agat       c.-181

 .         .         .         .         .         .                g.1064
 tcctacttcttacgccccccacatcacccgcctcgagacctcaagggtagaggtgggcac       c.-121

 .         .         .         .         .         .                g.1124
 ccccgcctccgcacttttgctcggggctccagattgtagggcagggcggcgcttctcgga       c.-61

 .         .         .         .         .         .                g.1184
 aagcgaaagccggcggggcggggcgggtgccgcaggagaaagaggaagcgctggcagaca       c.-1

          .         .         .         .         .         .       g.1244
 ATGCGACCCGACCGCGCTGAGGCTCCAGGACCGCCCGCCATGGCTGCAGGAGGTCCCGGC       c.60
 M  R  P  D  R  A  E  A  P  G  P  P  A  M  A  A  G  G  P  G         p.20

          .         .         .         .         .         .       g.1304
 GCGGGGTCTGCGGCCCCGGTCTCCTCCACATCCTCCCTTCCCCTGGCTGCTCTCAACATG       c.120
 A  G  S  A  A  P  V  S  S  T  S  S  L  P  L  A  A  L  N  M         p.40

          .         .         .         .         .         .       g.1364
 CGAGTGCGGCGCCGCCTGTCTCTGTTCTTGAACGTGCGGACACAGGTGGCGGCCGACTGG       c.180
 R  V  R  R  R  L  S  L  F  L  N  V  R  T  Q  V  A  A  D  W         p.60

          .         .         .         .         .         .       g.1424
 ACCGCGCTGGCGGAGGAGATGGACTTTGAGTACTTGGAGATCCGGCAACTGGAGACACAA       c.240
 T  A  L  A  E  E  M  D  F  E  Y  L  E  I  R  Q  L  E  T  Q         p.80

          .         .         .         .         .         .       g.1484
 GCGGACCCCACTGGCAGGCTGCTGGACGCCTGGCAGGGACGCCCTGGCGCCTCTGTAGGC       c.300
 A  D  P  T  G  R  L  L  D  A  W  Q  G  R  P  G  A  S  V  G         p.100

          .         .         .         .         .         .       g.1544
 CGACTGCTCGAGCTGCTTACCAAGCTGGGCCGCGACGACGTGCTGCTGGAGCTGGGACCC       c.360
 R  L  L  E  L  L  T  K  L  G  R  D  D  V  L  L  E  L  G  P         p.120

         | 02.         .         .         .         .         .    g.2439
 AGCATTG | AGGAGGATTGCCAAAAGTATATCTTGAAGCAGCAGCAGGAGGAGGCTGAGAAG    c.420
 S  I  E |   E  D  C  Q  K  Y  I  L  K  Q  Q  Q  E  E  A  E  K      p.140

          .         .         .         .         .         .       g.2499
 CCTTTACAGGTGGCCGCTGTAGACAGCAGTGTCCCACGGACAGCAGAGCTGGCGGGCATC       c.480
 P  L  Q  V  A  A  V  D  S  S  V  P  R  T  A  E  L  A  G  I         p.160

          .         .   | 03     .         .         .         .    g.2948
 ACCACACTTGATGACCCCCTGG | GGCATATGCCTGAGCGTTTCGATGCCTTCATCTGCTAT    c.540
 T  T  L  D  D  P  L  G |   H  M  P  E  R  F  D  A  F  I  C  Y      p.180

          .         .         .         .         .         .       g.3008
 TGCCCCAGCGACATCCAGTTTGTGCAGGAGATGATCCGGCAACTGGAACAGACAAACTAT       c.600
 C  P  S  D  I  Q  F  V  Q  E  M  I  R  Q  L  E  Q  T  N  Y         p.200

          .         .         .         .         .         .       g.3068
 CGACTGAAGTTGTGTGTGTCTGACCGCGATGTCCTGCCTGGCACCTGTGTCTGGTCTATT       c.660
 R  L  K  L  C  V  S  D  R  D  V  L  P  G  T  C  V  W  S  I         p.220

          .         .    | 04    .         .         .         .    g.3316
 GCTAGTGAGCTCATCGAAAAGAG | GTGCCGCCGGATGGTGGTGGTTGTCTCTGATGATTAC    c.720
 A  S  E  L  I  E  K  R  |  C  R  R  M  V  V  V  V  S  D  D  Y      p.240

          .         .         .         .         .      | 05  .    g.3659
 CTGCAGAGCAAGGAATGTGACTTCCAGACCAAATTTGCACTCAGCCTCTCTCCAG | GTGCC    c.780
 L  Q  S  K  E  C  D  F  Q  T  K  F  A  L  S  L  S  P  G |   A      p.260

          .         .         .         .         .         .       g.3719
 CATCAGAAGCGACTGATCCCCATCAAGTACAAGGCAATGAAGAAAGAGTTCCCCAGCATC       c.840
 H  Q  K  R  L  I  P  I  K  Y  K  A  M  K  K  E  F  P  S  I         p.280

          .         .         .         .         .         .       g.3779
 CTGAGGTTCATCACTGTCTGCGACTACACCAACCCCTGCACCAAATCTTGGTTCTGGACT       c.900
 L  R  F  I  T  V  C  D  Y  T  N  P  C  T  K  S  W  F  W  T         p.300

          .         .         .                                     g.3809
 CGCCTTGCCAAGGCCTTGTCCCTGCCCTGA                                     c.930
 R  L  A  K  A  L  S  L  P  X                                       p.309

          .         .         .         .         .         .       g.3869
 agactgttctgaggccctgggtgtgtgtgtatctgtctgcctgtccatgtacttctgccc       c.*60

          .         .         .         .         .         .       g.3929
 tgcctcctcctttcgttgtaggaggaatctgtgctctacttacctctcaattcctggaga       c.*120

          .         .         .         .         .         .       g.3989
 tgccaacttcacagacacgtctgcagcagctggacatcacatttcatgtcctgcatggaa       c.*180

          .         .         .         .         .         .       g.4049
 ccagtggctgtgagtggcatgtccacttgctggattatcagccaggacactatagaacag       c.*240

          .         .         .         .         .         .       g.4109
 gaccagctgagactaagaaggaccagcagagccagctcagctctgagccattcacacatc       c.*300

          .         .         .         .         .         .       g.4169
 ttcaccctcagtttcctcacttgaggagtgggatggggagaacagagagtagctgtgttt       c.*360

          .         .         .         .         .         .       g.4229
 gaatccctgtaggaaatggtgaagcatagctctgggtctcctgggggagaccaggcttgg       c.*420

          .         .         .         .         .         .       g.4289
 ctgcgggagagctggctgttgctggactacatgctggccactgctgtgaccacgacactg       c.*480

          .         .         .         .         .         .       g.4349
 ctggggcagcttcttccacagtgatgcctactgatgcttcagtgcctctgcacaccgccc       c.*540

          .         .         .         .         .         .       g.4409
 attccacttcctccttccccacagggcaggtggggaagcagtttggcccagcccaaggag       c.*600

          .         .         .         .         .         .       g.4469
 accccaccttgagccttatttcctaatgggtccacctctcatctgcatctttcacacctc       c.*660

          .         .         .         .         .         .       g.4529
 ccagcttctgcccaaccttcagcagtgacaagtccccaagagactcgcctgagcagcttg       c.*720

          .         .         .         .         .         .       g.4589
 ggctgcttttcatttccacctgtcaggatgcctgtggtcatgctctcagctccacctggc       c.*780

          .         .         .         .         .         .       g.4649
 atgagaagggatcctggcctctggcatattcatcaagtatgagttctggggatgagtcac       c.*840

          .         .         .         .         .         .       g.4709
 tgtaatgatgtgagcagggagccttcctccctgggccacctgcagagagctttcccacca       c.*900

          .         .         .         .         .         .       g.4769
 actttgtaccttgattgccttacaaagttatttgtttacaaacagcgaccatataaaagc       c.*960

          .         .         .         .         .         .       g.4829
 ctcctgccccaaagcttgtgggcacatgggcacatacagactcacatacagacacacaca       c.*1020

          .         .         .         .         .         .       g.4889
 tatatgtacagacatgtactctcacacacacaggcaccagcatacacacgtttttctagg       c.*1080

          .         .         .         .         .         .       g.4949
 tacagctcccaggaacagctaggtgggaaagtcccatcactgagggagcctaaccatgtc       c.*1140

          .         .         .         .         .         .       g.5009
 cctgaacaaaaattgggcactcatctattccttttctcttgtgtccctactcattgaaac       c.*1200

          .         .         .         .         .         .       g.5069
 caaactctggaaaggacccaatgtaccagtatttatacctctaatgaagcacagagagag       c.*1260

          .         .         .         .         .         .       g.5129
 gaagagagctgcttaaactcacacaacaatgaactgcagacacagctgttctctccctct       c.*1320

          .         .         .         .         .         .       g.5189
 ctccttcccagagcaatttatactttaccctcaggctgtcctctggggagaaggtgccat       c.*1380

          .         .         .         .         .         .       g.5249
 ggtcttaggtgtctgtgccccaggacagaccctaggaccctaaatccaatagaaaatgca       c.*1440

          .         .         .         .         .         .       g.5309
 tatctttgctccactttcagccaggctggagcaaggtaccttttcttaggatcttgggag       c.*1500

          .         .         .         .         .         .       g.5369
 ggaatggatgcccctctctgcatgatcttgttgaggcatttagctgccatgcacctgtcc       c.*1560

          .         .         .         .         .         .       g.5429
 ccctttaatactgggcattttaaagccatctcaagaggcatcttctacatgttttgtacg       c.*1620

          .         .         .         .         .         .       g.5489
 cattaaaataatttcaaagatatctgagaaaagccgatatttgccattcttcctatatcc       c.*1680

          .         .         .         .         .                 g.5545
 tggaatatatcttgcatcctgagtttataataataaataatattctaccttggaaa           c.*1736

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Myeloid differentiation primary response 88 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.