MYO15A myosin XVA (MYO15A) - coding DNA reference sequence

(used for mutation description)

(last modified July 11, 2013)


This file was created to facilitate the description of sequence variants in the MYO15A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011634.1, covering MYO15A transcript NM_016239.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
(upstream sequence) 
                               .         .         .                g.38
                       gggctgggcctcccttccccataacactgagctgctct       c.-301

 .         .         .         .         .         .                g.98
 gctgggccaaccgtgctcctgggccagccagaggacccccatgaggcggcatgcaggcgg       c.-241

 .         .         . | 02       .         .         .             g.9915
 ggagcaggccacagaacgcag | ggtgaaacccaaggcgctctagaggagatgaattatgga    c.-181

 .         .         .         .         .         .                g.9975
 tccgccctcccggaatcctggctcggccctccccacgccacccagggccagtcgggtctg       c.-121

 .         .         .         .         .         .                g.10035
 ctcacagcccgaggaggccgcgtgtccagccgcgggcaagagacagagcaggtccctgtg       c.-61

 .         .         .         .         .         .                g.10095
 tctccaagtccctgagcccgtgacaccggccccaggccctgtagagagcaggcagccacc       c.-1

          .         .         .         .         .         .       g.10155
 ATGGCGAAGGAGGAAGATGAGGAGAAGAAAGCCAAGAAAGGGAAGAAGGGGAAGAAGGCA       c.60
 M  A  K  E  E  D  E  E  K  K  A  K  K  G  K  K  G  K  K  A         p.20

          .         .         .         .         .         .       g.10215
 CCGGAGCCGGAGAAGCCCAAACGGAGCCTGAAGGGGACGTCGCGGCTGTTCATGGGCTTC       c.120
 P  E  P  E  K  P  K  R  S  L  K  G  T  S  R  L  F  M  G  F         p.40

          .         .         .         .         .         .       g.10275
 CGCGACCGTACACCCAAGATCTCCAAGAAGGGCCAGTTCCGCAGCGCCTCGGCCTTCTTC       c.180
 R  D  R  T  P  K  I  S  K  K  G  Q  F  R  S  A  S  A  F  F         p.60

          .         .         .         .         .         .       g.10335
 TGGGGCCTCCACACCGGCCCCCAGAAGACCAAGCGCAAGAGGAAGGCCCGCACCGTGCTC       c.240
 W  G  L  H  T  G  P  Q  K  T  K  R  K  R  K  A  R  T  V  L         p.80

          .         .         .         .         .         .       g.10395
 AAGTCCACGTCAAAGCTCATGACGCAGATGCGCATGGGCAAGAAGAAGCGGGCGATGAAG       c.300
 K  S  T  S  K  L  M  T  Q  M  R  M  G  K  K  K  R  A  M  K         p.100

          .         .         .         .         .         .       g.10455
 GGCAAGAAGCCGTCCTTCATGGTGATCCGCTTCCCAGGCCGCCGTGGCTACGGCCGCCTG       c.360
 G  K  K  P  S  F  M  V  I  R  F  P  G  R  R  G  Y  G  R  L         p.120

          .         .         .         .         .         .       g.10515
 CGGCCGCGCGCCCGGTCACTCAGCAAAGCGTCCACGGCCATCAACTGGCTCACAAAAAAG       c.420
 R  P  R  A  R  S  L  S  K  A  S  T  A  I  N  W  L  T  K  K         p.140

          .         .         .         .         .         .       g.10575
 TTCCTCCTCAAGAAGGCCGAGGAGTCGGGCAGCGAACAGGCCACAGTGGACGCCTGGCTG       c.480
 F  L  L  K  K  A  E  E  S  G  S  E  Q  A  T  V  D  A  W  L         p.160

          .         .         .         .         .         .       g.10635
 CAGCGCTCGAGCTCCCGCATGGGCTCCCGCAAACTCCCCTTCCCGTCGGGTGCCGAGATC       c.540
 Q  R  S  S  S  R  M  G  S  R  K  L  P  F  P  S  G  A  E  I         p.180

          .         .         .         .         .         .       g.10695
 CTGCGGCCTGGGGGCCGGCTCCGGAGGTTCCCCCGCAGCCGCAGCATCTACGCGTCAGGC       c.600
 L  R  P  G  G  R  L  R  R  F  P  R  S  R  S  I  Y  A  S  G         p.200

          .         .         .         .         .         .       g.10755
 GAGCCCCTGGGCTTCCTGCCCTTCGAGGACGAGGCCCCATTCCATCACTCGGGCTCCCGC       c.660
 E  P  L  G  F  L  P  F  E  D  E  A  P  F  H  H  S  G  S  R         p.220

          .         .         .         .         .         .       g.10815
 AAGTCGCTGTACGGGCTTGAGGGCTTCCAGGACCTGGGCGAGTATTATGACTATCACCGC       c.720
 K  S  L  Y  G  L  E  G  F  Q  D  L  G  E  Y  Y  D  Y  H  R         p.240

          .         .         .         .         .         .       g.10875
 GACGGCGACGACTACTACGACCGGCAGTCACTCCACCGCTACGAGGAGCAGGAACCCTAC       c.780
 D  G  D  D  Y  Y  D  R  Q  S  L  H  R  Y  E  E  Q  E  P  Y         p.260

          .         .         .         .         .         .       g.10935
 CTGGCGGGCCTCGGCCCCTACAGCCCGGCCTGGCCACCCTACGGCGACCACTACTACGGG       c.840
 L  A  G  L  G  P  Y  S  P  A  W  P  P  Y  G  D  H  Y  Y  G         p.280

          .         .         .         .         .         .       g.10995
 TACCCGCCCGAGGATCCCTACGACTACTACCACCCCGACTATTACGGTGGCCCCTTTGAT       c.900
 Y  P  P  E  D  P  Y  D  Y  Y  H  P  D  Y  Y  G  G  P  F  D         p.300

          .         .         .         .         .         .       g.11055
 CCGGGGTACACCTACGGCTACGGCTACGACGATTACGAACCCCCATATGCGCCCCCGTCG       c.960
 P  G  Y  T  Y  G  Y  G  Y  D  D  Y  E  P  P  Y  A  P  P  S         p.320

          .         .         .         .         .         .       g.11115
 GGGTACTCGTCTCCTTACAGCTACCACGATGGGTACGAGGGCGAGGCGCACCCTTATGGC       c.1020
 G  Y  S  S  P  Y  S  Y  H  D  G  Y  E  G  E  A  H  P  Y  G         p.340

          .         .         .         .         .         .       g.11175
 TACTACCTGGATCCCTATGCGCCGTACGACGCGCCATACCCACCCTATGACCTCCCATAC       c.1080
 Y  Y  L  D  P  Y  A  P  Y  D  A  P  Y  P  P  Y  D  L  P  Y         p.360

          .         .         .         .         .         .       g.11235
 CACACTCCCTACGATGTACCCTACTTTGATCCCTACGGAGTCCACTACACCGTCCCCTAT       c.1140
 H  T  P  Y  D  V  P  Y  F  D  P  Y  G  V  H  Y  T  V  P  Y         p.380

          .         .         .         .         .         .       g.11295
 GCCGAAGGCGTCTATGGCGGTGGGGACGAGGCCATCTACCCCCCCGAGGTGCCCTATTTT       c.1200
 A  E  G  V  Y  G  G  G  D  E  A  I  Y  P  P  E  V  P  Y  F         p.400

          .         .         .         .         .         .       g.11355
 TACCCGGAGGAGTCGGCTTCGGCCTTTGTGTACCCCTGGGTACCACCGCCCATCCCGTCG       c.1260
 Y  P  E  E  S  A  S  A  F  V  Y  P  W  V  P  P  P  I  P  S         p.420

          .         .         .         .         .         .       g.11415
 CCCCACAACCCGTATGCCCACGCCATGGATGACATCGCCGAGCTGGAGGAACCAGAGGAC       c.1320
 P  H  N  P  Y  A  H  A  M  D  D  I  A  E  L  E  E  P  E  D         p.440

          .         .         .         .         .         .       g.11475
 GCGGGCGTAGAGCGTCAGGGGACCTCCTTCCGCCTGCCCAGCGCCGCCTTCTTCGAGCAG       c.1380
 A  G  V  E  R  Q  G  T  S  F  R  L  P  S  A  A  F  F  E  Q         p.460

          .         .         .         .         .         .       g.11535
 CAAGGCATGGATAAGCCCGCCAGGTCCAAGCTGTCCCTCATCCGCAAGTTCCGCCTCTTC       c.1440
 Q  G  M  D  K  P  A  R  S  K  L  S  L  I  R  K  F  R  L  F         p.480

          .         .         .         .         .         .       g.11595
 CCGCGACCCCAGGTGAAGCTGTTTGGGAAGGAGAAGCTGGAGGTGCCCCTGCCACCCTCT       c.1500
 P  R  P  Q  V  K  L  F  G  K  E  K  L  E  V  P  L  P  P  S         p.500

          .         .         .         .         .         .       g.11655
 CTGGACATTCCTCTCCCCTTGGGGGATGCGGACGAAGAAGAGGACGAGGAGGAGCTGCCC       c.1560
 L  D  I  P  L  P  L  G  D  A  D  E  E  E  D  E  E  E  L  P         p.520

          .         .         .         .         .         .       g.11715
 CCGGTTTCCGCTGTGCCCTACGGCCACCCTTTCTGGGGCTTCCTCACGCCGCGCCAGCGC       c.1620
 P  V  S  A  V  P  Y  G  H  P  F  W  G  F  L  T  P  R  Q  R         p.540

          .         .         .         .         .         .       g.11775
 AACCTCCAGCGCGCGCTGTCGGCCTTCGGCGCCCACCGGGGCCTGGGCTTCGGCCCTGAG       c.1680
 N  L  Q  R  A  L  S  A  F  G  A  H  R  G  L  G  F  G  P  E         p.560

          .         .         .         .         .         .       g.11835
 TTTGGCCGCCCCGTGCCTCGCCCTGCCACCTCGCTTGCGCGGTTCCTCAAGAAGACGCTG       c.1740
 F  G  R  P  V  P  R  P  A  T  S  L  A  R  F  L  K  K  T  L         p.580

          .         .         .         .         .         .       g.11895
 TCGGAGAAGAAGCCCATCGCGCGGCTCAGGGGCAGCCAGAAGGCCCGGGCGGGCGGCCCT       c.1800
 S  E  K  K  P  I  A  R  L  R  G  S  Q  K  A  R  A  G  G  P         p.600

          .         .         .         .         .         .       g.11955
 GCTGTCAGGGAGGCGGCCTACAAACGCTTCGGCTACAAGCTGGCTGGCATGGACCCCGAG       c.1860
 A  V  R  E  A  A  Y  K  R  F  G  Y  K  L  A  G  M  D  P  E         p.620

          .         .         .         .         .         .       g.12015
 AAGCCCGGCACGCCCATCGTGCTGAGGAGGGCCCAGCCACGCGCTCGCAGCAGCAACGAC       c.1920
 K  P  G  T  P  I  V  L  R  R  A  Q  P  R  A  R  S  S  N  D         p.640

          .         .         .         .         .         .       g.12075
 GCGCGCCGCCCGCCCGCGCCACAGCCCGCGCCCAGGACCCTCTCCCACTGGAGCGCGCTC       c.1980
 A  R  R  P  P  A  P  Q  P  A  P  R  T  L  S  H  W  S  A  L         p.660

          .         .         .         .         .         .       g.12135
 CTGTCTCCGCCCGTGCCCCCGCGGCCCCCAAGCTCCGGGCCCCCGCCCGCGCCGCCGCTC       c.2040
 L  S  P  P  V  P  P  R  P  P  S  S  G  P  P  P  A  P  P  L         p.680

          .         .         .         .         .         .       g.12195
 TCCCCGGCGCTCTCGGGCCTGCCCCGGCCGGCCTCGCCCTACGGCTCCCTCCGCCGCCAC       c.2100
 S  P  A  L  S  G  L  P  R  P  A  S  P  Y  G  S  L  R  R  H         p.700

          .         .         .         .         .         .       g.12255
 CCGCCGCCCTGGGCCGCCCCAGCGCACGTGCCACCGGCGCCGCAGGCCAGCTGGTGGGCC       c.2160
 P  P  P  W  A  A  P  A  H  V  P  P  A  P  Q  A  S  W  W  A         p.720

          .         .         .         .         .         .       g.12315
 TTCGTGGAGCCCCCTGCCGTGAGCCCGGAGGTGCCCCCCGACCTACTAGCCTTCCCAGGG       c.2220
 F  V  E  P  P  A  V  S  P  E  V  P  P  D  L  L  A  F  P  G         p.740

          .         .         .         .         .         .       g.12375
 CCCCGACCCTCGTTCAGGGGCTCCCGCCGGAGAGGGGCGGCTTTCGGCTTCCCCGGGGCC       c.2280
 P  R  P  S  F  R  G  S  R  R  R  G  A  A  F  G  F  P  G  A         p.760

          .         .         .         .         .         .       g.12435
 TCTCCACGGGCGTCGCGGAGGCGAGCTTGGTCACCGCTGGCCTCGCCCCAGCCCTCGCTG       c.2340
 S  P  R  A  S  R  R  R  A  W  S  P  L  A  S  P  Q  P  S  L         p.780

          .         .         .         .         .         .       g.12495
 AGGAGCTCGCCGGGCCTCGGCTACTGCTCACCCTTGGCGCCCCCGTCGCCTCAGCTGTCC       c.2400
 R  S  S  P  G  L  G  Y  C  S  P  L  A  P  P  S  P  Q  L  S         p.800

          .         .         .         .         .         .       g.12555
 TTGCGCACGGGCCCCTTCCAGCCGCCCTTCCTGCCCCCGGCCCGCCGGCCCCGCTCGCTG       c.2460
 L  R  T  G  P  F  Q  P  P  F  L  P  P  A  R  R  P  R  S  L         p.820

          .         .         .         .         .         .       g.12615
 CAGGAGTCCCCAGCCCCACGCCGAGCCGCTGGGCGCCTGGGCCCACCCGGCTCGCCGCTG       c.2520
 Q  E  S  P  A  P  R  R  A  A  G  R  L  G  P  P  G  S  P  L         p.840

          .         .         .         .         .         .       g.12675
 CCGGGCTCACCCAGGCCGCCCTCGCCGCCCCTGGGGCTCTGCCACAGCCCGCGGCGCAGC       c.2580
 P  G  S  P  R  P  P  S  P  P  L  G  L  C  H  S  P  R  R  S         p.860

          .         .         .         .         .         .       g.12735
 TCCCTGAATCTGCCCTCGCGCCTCCCGCACACGTGGCGGCGCCTCAGCGAGCCACCCACT       c.2640
 S  L  N  L  P  S  R  L  P  H  T  W  R  R  L  S  E  P  P  T         p.880

          .         .         .         .         .         .       g.12795
 CGGGCTGTGAAGCCGCAAGTGCGCCTGCCCTTCCACCGACCGCCCAGGGCCGGGGCCTGG       c.2700
 R  A  V  K  P  Q  V  R  L  P  F  H  R  P  P  R  A  G  A  W         p.900

          .         .         .         .         .         .       g.12855
 CGGGCGCCCCTGGAACACCGGGAGAGCCCGCGAGAACCCGAGGACTCAGAGACGCCCTGG       c.2760
 R  A  P  L  E  H  R  E  S  P  R  E  P  E  D  S  E  T  P  W         p.920

          .         .         .         .         .         .       g.12915
 ACTGTGCCCCCACTGGCCCCCAGCTGGGACGTGGACATGCCTCCCACCCAACGCCCACCC       c.2820
 T  V  P  P  L  A  P  S  W  D  V  D  M  P  P  T  Q  R  P  P         p.940

          .         .         .         .         .         .       g.12975
 TCCCCCTGGCCAGGAGGTGCAGGCAGCCGCCGAGGCTTTTCCAGGCCACCCCCTGTGCCG       c.2880
 S  P  W  P  G  G  A  G  S  R  R  G  F  S  R  P  P  P  V  P         p.960

          .         .         .         .         .         .       g.13035
 GAAAACCCCTTTCTCCAGCTCCTGGGCCCTGTGCCATCCCCCACCCTCCAGCCTGAGGAT       c.2940
 E  N  P  F  L  Q  L  L  G  P  V  P  S  P  T  L  Q  P  E  D         p.980

          .         .         .         .         .         .       g.13095
 CCAGCTGCTGATATGACCAGGGTCTTCCTGGGCAGACACCATGAGCCGGGGCCTGGACAG       c.3000
 P  A  A  D  M  T  R  V  F  L  G  R  H  H  E  P  G  P  G  Q         p.1000

          .         .         .         .         .         .       g.13155
 CTCACCAAATCAGCTGGCCCAACCCCTGAGAAGCCTGAAGAAGAGGCCACCCTGGGGGAC       c.3060
 L  T  K  S  A  G  P  T  P  E  K  P  E  E  E  A  T  L  G  D         p.1020

          .         .         .         .         .         .       g.13215
 CCCCAGCTGCCAGCAGAGACCAAGCCTCCAACCCCAGCACCTCCCAAGGATGTCACTCCC       c.3120
 P  Q  L  P  A  E  T  K  P  P  T  P  A  P  P  K  D  V  T  P         p.1040

          .         .         .         .         .         .       g.13275
 CCCAAGGATATCACTCCCCCCAAGGATGTCCTCCCAGAGCAAAAGACATTAAGGCCCAGC       c.3180
 P  K  D  I  T  P  P  K  D  V  L  P  E  Q  K  T  L  R  P  S         p.1060

          .         .         .         .         .         .       g.13335
 CTCTCATACCCACTGGCTGCGTGTGACCAGACCAGGGCCACATGGCCACCATGGCACCGC       c.3240
 L  S  Y  P  L  A  A  C  D  Q  T  R  A  T  W  P  P  W  H  R         p.1080

          .         .         .         .         .         .       g.13395
 TGGGGAACACTGCCCCAAGCCGCAGCCCCCTTGGCGCCCATCAGGGCCCCAGAGCCCCTG       c.3300
 W  G  T  L  P  Q  A  A  A  P  L  A  P  I  R  A  P  E  P  L         p.1100

          .         .         .         .         .         .       g.13455
 CCCAAGGGGGGTGAACGGCGCCAGGCAGCCCCTGGGCGTTTTGCTGTGGTCATGCCTCGT       c.3360
 P  K  G  G  E  R  R  Q  A  A  P  G  R  F  A  V  V  M  P  R         p.1120

          .         .         .         .         .         .       g.13515
 GTGCAGAAGCTGAGCTCTTTCCAGCGAGTTGGGCCTGCAACCCTGAAGCCTCAAGTCCAG       c.3420
 V  Q  K  L  S  S  F  Q  R  V  G  P  A  T  L  K  P  Q  V  Q         p.1140

          .         .         .         .         .         .       g.13575
 CCCATTCAGGACCCCAAGCCAAGAGCCTGTAGTCTTCGCTGGTCCTGCCTCTGGCTTCGG       c.3480
 P  I  Q  D  P  K  P  R  A  C  S  L  R  W  S  C  L  W  L  R         p.1160

          .         .         .         .         .         .       g.13635
 GCAGATGCCTATGGACCCTGGCCACGAGTACACACCCATCCCCAGTCCTGCCACCTGGGC       c.3540
 A  D  A  Y  G  P  W  P  R  V  H  T  H  P  Q  S  C  H  L  G         p.1180

          .         .         .         .         .         .       g.13695
 CCTGGAGCTGCCTGCCTGTCCCTTAGGGGCTCCTGGGAGGAGGTCGGCCCGCCAAGCTGG       c.3600
 P  G  A  A  C  L  S  L  R  G  S  W  E  E  V  G  P  P  S  W         p.1200

           | 03        .         .         .         .         .    g.15828
 CGGAACAAG | ATGCACTCCATCCGCAACCTGCCATCCATGCGGTTCCGTGAGCAGCACGGG    c.3660
 R  N  K   | M  H  S  I  R  N  L  P  S  M  R  F  R  E  Q  H  G      p.1220

          .         .         .   | 04     .         .         .    g.16490
 GAGGATGGTGTGGAGGACATGACACAGCTGGA | AGACCTCCAGGAAACCACTGTGCTGTCC    c.3720
 E  D  G  V  E  D  M  T  Q  L  E  |  D  L  Q  E  T  T  V  L  S      p.1240

          .         .         .       | 05 .         .         .    g.17665
 AACCTCAAGATTAGATTTGAACGGAACCTCATCTAC | ACATACATTGGGAGCATCCTGGTG    c.3780
 N  L  K  I  R  F  E  R  N  L  I  Y   | T  Y  I  G  S  I  L  V      p.1260

          .         .         .         .         .         .       g.17725
 TCGGTGAACCCATACCAAATGTTTGGAATCTATGGGCCGGAGCAGGTGCAGCAGTACAAC       c.3840
 S  V  N  P  Y  Q  M  F  G  I  Y  G  P  E  Q  V  Q  Q  Y  N         p.1280

          .         .       | 06 .         .         .         .    g.18119
 GGACGGGCCCTGGGAGAGAATCCCCC | GCACCTCTTTGCTGTTGCAAATCTCGCCTTCGCC    c.3900
 G  R  A  L  G  E  N  P  P  |  H  L  F  A  V  A  N  L  A  F  A      p.1300

          .         .         .         .  | 07      .         .    g.18388
 AAAATGCTCGATGCCAAACAGAACCAGTGCATAATCATTAG | TGGAGAGAGCGGCTCTGGC    c.3960
 K  M  L  D  A  K  Q  N  Q  C  I  I  I  S  |  G  E  S  G  S  G      p.1320

          .         .         .         .         .         .       g.18448
 AAAACTGAGGCCACCAAGCTGATTCTGCGCTACCTGGCCGCCATGAACCAGAAACGGGAG       c.4020
 K  T  E  A  T  K  L  I  L  R  Y  L  A  A  M  N  Q  K  R  E         p.1340

          .   | 08     | 09         .         .         .         . g.22575
 GTCATGCAGCAG | ATAAAG | ATCCTGGAGGCAACACCCCTCTTGGAGTCCTTCGGTAATGCC c.4080
 V  M  Q  Q   | I  K   | I  L  E  A  T  P  L  L  E  S  F  G  N  A   p.1360

          .         .         .         .         .         .       g.22635
 AAAACCGTCAGGAACGACAACTCCAGCCGCTTTGGGAAGTTTGTGGAAATCTTTCTGGAA       c.4140
 K  T  V  R  N  D  N  S  S  R  F  G  K  F  V  E  I  F  L  E         p.1380

    | 10     .         .         .         .         .         .    g.22820
 GG | GGGCGTGATCTCTGGTGCCATAACCTCCCAGTACCTGCTTGAGAAATCCAGGATCGTG    c.4200
 G  |  G  V  I  S  G  A  I  T  S  Q  Y  L  L  E  K  S  R  I  V      p.1400

        | 11 .         .         .         .         .         .    g.23801
 TTTCAG | GCCAAAAACGAGAGGAATTACCACATCTTCTACGAGTTGCTGGCCGGGTTGCCT    c.4260
 F  Q   | A  K  N  E  R  N  Y  H  I  F  Y  E  L  L  A  G  L  P      p.1420

          .         .         .         .         .         .       g.23861
 GCCCAGCTCAGGCAGGCCTTTAGCCTGCAAGAGGCTGAGACCTACTACTATCTGAACCAG       c.4320
 A  Q  L  R  Q  A  F  S  L  Q  E  A  E  T  Y  Y  Y  L  N  Q         p.1440

  | 12       .         .         .         .         .         .    g.24579
  | GGTGGGAACTGTGAGATAGCAGGAAAGAGCGATGCAGATGACTTTCGCCGGCTCCTGGCT    c.4380
  | G  G  N  C  E  I  A  G  K  S  D  A  D  D  F  R  R  L  L  A      p.1460

          .         .         .         .         .         .       g.24639
 GCCATGGAGGTGTTGGGCTTCAGCAGTGAGGACCAGGACAGCATCTTCCGCATCCTGGCC       c.4440
 A  M  E  V  L  G  F  S  S  E  D  Q  D  S  I  F  R  I  L  A         p.1480

          .         .         .         .   | 13     .         .    g.27023
 TCCATCCTGCACCTGGGCAACGTCTACTTTGAGAAGTATGAG | ACGGATGCACAGGAGGTG    c.4500
 S  I  L  H  L  G  N  V  Y  F  E  K  Y  E   | T  D  A  Q  E  V      p.1500

          .         .         .         .         .         .       g.27083
 GCCTCAGTGGTGAGTGCCCGAGAGATCCAGGCCGTGGCAGAGCTGCTGCAGATCTCCCCT       c.4560
 A  S  V  V  S  A  R  E  I  Q  A  V  A  E  L  L  Q  I  S  P         p.1520

          .         .         .       | 14 .         .         .    g.27735
 GAGGGCCTGCAGAAGGCCATCACCTTCAAAGTGACC | GAGACAATGCGAGAGAAGATCTTC    c.4620
 E  G  L  Q  K  A  I  T  F  K  V  T   | E  T  M  R  E  K  I  F      p.1540

          .         .         .      | 15  .         .         .    g.27882
 ACGCCCCTAACTGTGGAGAGCGCTGTGGATGCCAG | GGACGCCATCGCCAAGGTCTTGTAT    c.4680
 T  P  L  T  V  E  S  A  V  D  A  R  |  D  A  I  A  K  V  L  Y      p.1560

          .         .         .         .         .         .       g.27942
 GCACTGCTGTTCAGCTGGCTCATCACCAGGGTCAACGCGCTGGTGTCCCCAAGGCAGGAC       c.4740
 A  L  L  F  S  W  L  I  T  R  V  N  A  L  V  S  P  R  Q  D         p.1580

          .         .         .          | 16        .         .    g.28899
 ACACTGTCCATCGCCATCCTGGACATCTATGGTTTCGAG | GACCTGAGCTTCAACAGCTTT    c.4800
 T  L  S  I  A  I  L  D  I  Y  G  F  E   | D  L  S  F  N  S  F      p.1600

          .         .         .         .         .         .       g.28959
 GAGCAGCTGTGTATTAACTACGCAAACGAGAACCTTCAGTACCTTTTCAACAAGATCGTC       c.4860
 E  Q  L  C  I  N  Y  A  N  E  N  L  Q  Y  L  F  N  K  I  V         p.1620

          .      | 17  .         .         .         .         .    g.29454
 TTCCAGGAGGAGCAG | GAGGAGTACATCCGTGAGCAGATAGACTGGCAGGAGATCACCTTT    c.4920
 F  Q  E  E  Q   | E  E  Y  I  R  E  Q  I  D  W  Q  E  I  T  F      p.1640

          .         .         .         .         .         .       g.29514
 GCTGACAACCAGCCCTGCATCAACCTCATCTCACTGAAGCCTTATGGCATCCTGCGGATC       c.4980
 A  D  N  Q  P  C  I  N  L  I  S  L  K  P  Y  G  I  L  R  I         p.1660

          .         .        | 18.         .         .         .    g.30138
 CTTGACGACCAGTGTTGCTTTCCCCAG | GCTACAGACCACACCTTCCTACAGAAGTGCCAC    c.5040
 L  D  D  Q  C  C  F  P  Q   | A  T  D  H  T  F  L  Q  K  C  H      p.1680

          .         .         .         .         .         .       g.30198
 TACCATCATGGCGCCAACCCGCTCTATTCCAAACCCAAGATGCCGCTGCCTGAGTTCACC       c.5100
 Y  H  H  G  A  N  P  L  Y  S  K  P  K  M  P  L  P  E  F  T         p.1700

          .         .         .    | 19    .         .         .    g.30855
 ATCAAGCACTATGCAGGCAAGGTCACCTACCAG | GTGCACAAGTTCCTGGACAAGAACCAC    c.5160
 I  K  H  Y  A  G  K  V  T  Y  Q   | V  H  K  F  L  D  K  N  H      p.1720

          .         .         .         .         .  | 20      .    g.31820
 GACCAAGTGCGCCAGGATGTGCTGGACCTGTTCGTACGGAGCCGGACACGG | GTGGTGGCA    c.5220
 D  Q  V  R  Q  D  V  L  D  L  F  V  R  S  R  T  R   | V  V  A      p.1740

          .         .         .         .         .         .       g.31880
 CACCTCTTCTCCAGCCATGCCCCACAGGCTGCCCCTCAGCGCCTGGGCAAGAGCAGCTCC       c.5280
 H  L  F  S  S  H  A  P  Q  A  A  P  Q  R  L  G  K  S  S  S         p.1760

          .         .         .         .         .         .       g.31940
 GTCACTCGGCTCTACAAGGCGCACACTGTGGCCGCCAAGTTCCAGCAGTCACTCCTGGAT       c.5340
 V  T  R  L  Y  K  A  H  T  V  A  A  K  F  Q  Q  S  L  L  D         p.1780

          .         . | 21       .         .         .         .    g.32121
 CTGGTGGAAAAGATGGAGAG | GTGCAACCCCTTGTTCATGCGTTGCCTGAAGCCCAACCAC    c.5400
 L  V  E  K  M  E  R  |  C  N  P  L  F  M  R  C  L  K  P  N  H      p.1800

        | 22 .         .         .         .         .         .    g.32367
 AAGAAG | GAGCCAGGTCTCTTTGAGCCAGATGTGGTAATGGCACAATTACGCTATTCAGGG    c.5460
 K  K   | E  P  G  L  F  E  P  D  V  V  M  A  Q  L  R  Y  S  G      p.1820

          .         .         .         .         .         .       g.32427
 GTGCTGGAGACCGTGAGGATCCGCAAGGAGGGATTTCCAGTGCGCCTGCCTTTCCAGGGG       c.5520
 V  L  E  T  V  R  I  R  K  E  G  F  P  V  R  L  P  F  Q  G         p.1840

          .  | 23      .         .         .         .         .    g.32996
 TTCATCGACAG | GTACTGCTGTCTAGTGGCCCTCAAGCATGACCTGCCGGCTAATGGGGAC    c.5580
 F  I  D  R  |  Y  C  C  L  V  A  L  K  H  D  L  P  A  N  G  D      p.1860

          .         .         .         .         .         .       g.33056
 ATGTGTGTGTCAGTGCTGAGTCGCCTGTGCAAAGTCATGCCAAACATGTACCGTGTTGGG       c.5640
 M  C  V  S  V  L  S  R  L  C  K  V  M  P  N  M  Y  R  V  G         p.1880

           | 24        .         .         .         .         .    g.33424
 GTCAGCAAG | CTGTTCCTTAAGGAACACCTATACCAGCTGCTGGAGAGTATGCGAGAGCAT    c.5700
 V  S  K   | L  F  L  K  E  H  L  Y  Q  L  L  E  S  M  R  E  H      p.1900

          .         .         .         .         .         .       g.33484
 GTCCTGAATCTGGCAGCCCTCACTCTGCAGCGCTGCCTCCGTGGCTTCTTCATTAAGCGG       c.5760
 V  L  N  L  A  A  L  T  L  Q  R  C  L  R  G  F  F  I  K  R         p.1920

          .         .         .         .         .         .       g.33544
 CGATTCCGCTCTCTGCGCCACAAGATCATCCTGCTGCAAAGCCGGGCCCGTGGCTACCTT       c.5820
 R  F  R  S  L  R  H  K  I  I  L  L  Q  S  R  A  R  G  Y  L         p.1940

       | 25  .         .         .         .         .         .    g.34105
 GCCAG | GCAACGCTATCAGCAGATGAGGAGGAGTCTGGTGAAGTTCCGGTCCCTGGTACAC    c.5880
 A  R  |  Q  R  Y  Q  Q  M  R  R  S  L  V  K  F  R  S  L  V  H      p.1960

          .         .         . | 26       .         .         .    g.34890
 GCATACGTGAGCCGCCGACGCTATCTCAAG | CTGAGGGCAGAGTGGAGGTGCCAGGTGGAG    c.5940
 A  Y  V  S  R  R  R  Y  L  K   | L  R  A  E  W  R  C  Q  V  E      p.1980

          .         .     | 27   .         .         .         .    g.35045
 GGGGCGCTGCTGTGGGAGCAGGAG | GAGCTGAGCAAGCGGGAGGTAGTCGCTGTGGGGCAC    c.6000
 G  A  L  L  W  E  Q  E   | E  L  S  K  R  E  V  V  A  V  G  H      p.2000

          .         .         .         .       | 28 .         .    g.35178
 CTGGAGGTACCGGCTGAGCTGGCTGGGCTCTTGCAAGCAGTGGCAG | GCCTCGGGCTGGCC    c.6060
 L  E  V  P  A  E  L  A  G  L  L  Q  A  V  A  G |   L  G  L  A      p.2020

          .         .         .         .         .         .       g.35238
 CAGGTGCCTCAGGTGGCCCCTGTGAGGACTCCTCGACTCCAGGCTGAGCCCCGTGTCACA       c.6120
 Q  V  P  Q  V  A  P  V  R  T  P  R  L  Q  A  E  P  R  V  T         p.2040

          .         .         .         .         .        | 29.    g.35794
 CTGCCCCTGGACATCAACAACTATCCTATGGCCAAGTTTGTCCAGTGCCACTTCAAG | GAA    c.6180
 L  P  L  D  I  N  N  Y  P  M  A  K  F  V  Q  C  H  F  K   | E      p.2060

          .         .         .         .         .         .       g.35854
 CCTGCCTTTGGGATGCTGACAGTGCCCCTGAGGACACCCCTCACGCAGCTGCCAGCCGAG       c.6240
 P  A  F  G  M  L  T  V  P  L  R  T  P  L  T  Q  L  P  A  E         p.2080

          .         .         .    | 30    .         .         .    g.37193
 CACCATGCAGAAGCCGTGAGCATCTTCAAGCTG | ATCCTGCGCTTCATGGGCGACCCCCAC    c.6300
 H  H  A  E  A  V  S  I  F  K  L   | I  L  R  F  M  G  D  P  H      p.2100

          .         .         .         .         .         .       g.37253
 CTGCATGGTGCCCGGGAGAACATCTTCGGGAACTACATCGTGCAGAAGGGGCTGGCGGTG       c.6360
 L  H  G  A  R  E  N  I  F  G  N  Y  I  V  Q  K  G  L  A  V         p.2120

          .         .         .         .         .         .       g.37313
 CCTGAGCTGCGGGATGAGATCCTGGCACAGCTGGCCAATCAGGTGTGGCACAATCACAAT       c.6420
 P  E  L  R  D  E  I  L  A  Q  L  A  N  Q  V  W  H  N  H  N         p.2140

          .         .         .         .         .         .       g.37373
 GCCCACAATGCTGAGCGGGGCTGGCTGCTGCTGGCCGCCTGCCTCAGTGGCTTTGCACCT       c.6480
 A  H  N  A  E  R  G  W  L  L  L  A  A  C  L  S  G  F  A  P         p.2160

          .         .          | 31        .         .         .    g.39354
 TCCCCGTGCTTCAACAAGTACCTTCTCAA | GTTTGTGTCTGATTATGGGCGGAATGGCTTC    c.6540
 S  P  C  F  N  K  Y  L  L  K  |  F  V  S  D  Y  G  R  N  G  F      p.2180

          .         .         .         .         .         .       g.39414
 CAGGCTGTGTGTCAGCACCGCCTCATGCAGGCCATGGGCCGGGCCCAACAGCAGGGCTCG       c.6600
 Q  A  V  C  Q  H  R  L  M  Q  A  M  G  R  A  Q  Q  Q  G  S         p.2200

          .         .         .         .         .         .       g.39474
 GGGGCTGCCCGCACCTTACCCCCGACCCAGCTCGAGTGGACAGCGACCTATGAGAAGGCC       c.6660
 G  A  A  R  T  L  P  P  T  Q  L  E  W  T  A  T  Y  E  K  A         p.2220

          .         .         .  | 32      .         .         .    g.39819
 AGCATGGCGCTGGACGTGGGCTGCTTCAATG | GTGACCAGTTCTCCTGCCCGGTGCACTCC    c.6720
 S  M  A  L  D  V  G  C  F  N  G |   D  Q  F  S  C  P  V  H  S      p.2240

          .         .         .         .     | 33   .         .    g.40071
 TGGAGTACGGGGGAAGAGGTGGCTGGAGACATTCTGAGGCACAG | GGGGCTGGCAGATGGC    c.6780
 W  S  T  G  E  E  V  A  G  D  I  L  R  H  R  |  G  L  A  D  G      p.2260

          .         .         .         .         .         .       g.40131
 TGGCGCGGCTGGACCGTGGCCATGAAGAATGGTGTCCAGTGGGCAGAGCTGGCTGGCCAC       c.6840
 W  R  G  W  T  V  A  M  K  N  G  V  Q  W  A  E  L  A  G  H         p.2280

          .         .         .         .         .         .       g.40191
 GACTACGTGTTAGACCTGGTGTCGGACCTGGAGCTGCTCAGGGACTTCCCTCGACAGAAG       c.6900
 D  Y  V  L  D  L  V  S  D  L  E  L  L  R  D  F  P  R  Q  K         p.2300

          .         .         .         .         .       | 34 .    g.40514
 TCCTACTTCATTGTGGGCACAGAGGGGCCTGCAGCCAGCAGGGGAGGCCCCAAAGT | GGTG    c.6960
 S  Y  F  I  V  G  T  E  G  P  A  A  S  R  G  G  P  K  V  |  V      p.2320

          .         .         .         .         .         .       g.40574
 TTTGGGAACAGCTGGGACTCGGATGAGGACATGTCCACTAGACCCCAGCCCCAGGAGCAC       c.7020
 F  G  N  S  W  D  S  D  E  D  M  S  T  R  P  Q  P  Q  E  H         p.2340

          .         .         .         .         .         .       g.40634
 ATGCCCAAAGTACTTGACTCTGATGGGTACAGCAGCCACAATCAGGACGGTACAAATGGG       c.7080
 M  P  K  V  L  D  S  D  G  Y  S  S  H  N  Q  D  G  T  N  G         p.2360

          .         .         .        | 35.         .         .    g.40803
 GAGACTGAGGCCCAAAGAGGGACAGCAACCCACCAAG | AGTCAGACAGTCTTGGAGAGCCT    c.7140
 E  T  E  A  Q  R  G  T  A  T  H  Q  E |   S  D  S  L  G  E  P      p.2380

          .         .         .         .         .         .       g.40863
 GCTGTGCCCCACAAGGGGCTGGACTGCTACCTGGATAGCCTCTTTGACCCTGTGCTGTCC       c.7200
 A  V  P  H  K  G  L  D  C  Y  L  D  S  L  F  D  P  V  L  S         p.2400

          .   | 36     .         .         .         .         .    g.41771
 TACGGGGATGCG | GACCTGGAGAAGCCAACAGCCATTGCCTACCGCATGAAAGGGGGAGGC    c.7260
 Y  G  D  A   | D  L  E  K  P  T  A  I  A  Y  R  M  K  G  G  G      p.2420

          .         .         .         .         .         .       g.41831
 CAGCCCGGTGGAGGCAGCAGTAGTGGTACTGAAGACACCCCCAGGAGACCCCCAGAGCCA       c.7320
 Q  P  G  G  G  S  S  S  G  T  E  D  T  P  R  R  P  P  E  P         p.2440

         | 37.         .         .         .         .         .    g.42045
 AAGCCAA | TCCCAGGCCTGGATGCCTCCACATTGGCTCTGCAGCAAGCCTTCATCCACAAA    c.7380
 K  P  I |   P  G  L  D  A  S  T  L  A  L  Q  Q  A  F  I  H  K      p.2460

          .      | 38  .         .         .         .         .    g.42175
 CAGGCCGTGCTGCTG | GCCCGGGAGATGACCCTGCAGGCCACGGCACTCCAGCAGCAGCCC    c.7440
 Q  A  V  L  L   | A  R  E  M  T  L  Q  A  T  A  L  Q  Q  Q  P      p.2480

          .         .         .    | 39    .         .         .    g.42431
 CTGAGTGCTGCCCTGAGATCCTTGCCCGCAGAG | AAACCCCCAGCACCAGAGGCACAGCCG    c.7500
 L  S  A  A  L  R  S  L  P  A  E   | K  P  P  A  P  E  A  Q  P      p.2500

          .         .         .         .         .         .       g.42491
 ACGTCTGTAGGCACCGGTCCCCCTGCCAAACCCGTGCTCCTGCGTGCCACTCCAAAGCCC       c.7560
 T  S  V  G  T  G  P  P  A  K  P  V  L  L  R  A  T  P  K  P         p.2520

          .         .         .         .         .         .       g.42551
 TTGGCCCCAGCCCCTCTGGCCAAGGCTCCAAGGCTCCCCATCAAGCCTGTGGCTGCCCCT       c.7620
 L  A  P  A  P  L  A  K  A  P  R  L  P  I  K  P  V  A  A  P         p.2540

          .         .         .     | 40   .         .         .    g.42715
 GTTCTAGCTCAGGATCAGGCTTCTCCAGAAACCA | CTTCACCCTCCCCAGAGCTGGTCCGG    c.7680
 V  L  A  Q  D  Q  A  S  P  E  T  T |   S  P  S  P  E  L  V  R      p.2560

          .         .         .         .         .         .       g.42775
 TACTCTACGCTCAACTCTGAGCACTTCCCACAGCCCACACAGCAGATCAAGAATATTGTC       c.7740
 Y  S  T  L  N  S  E  H  F  P  Q  P  T  Q  Q  I  K  N  I  V         p.2580

          .         .         .         .        | 41.         .    g.43153
 AGGCAGTACCAGCAGCCGTTCCGGGGAGGCCGGCCTGAGGCCCTCAG | GAAGGATGGCGGG    c.7800
 R  Q  Y  Q  Q  P  F  R  G  G  R  P  E  A  L  R  |  K  D  G  G      p.2600

          .         .         .         .         .         .       g.43213
 AAAGTGTTCATGAAGCGGCCAGACCCTCATGAGGAGGCCCTGATGATCCTGAAAGGGCAG       c.7860
 K  V  F  M  K  R  P  D  P  H  E  E  A  L  M  I  L  K  G  Q         p.2620

          .         .         .    | 42    .         .         .    g.43433
 ATGACCCACCTGGCAGCTGCACCTGGCACCCAG | GTGTCCAGAGAGGCCGTGGCCCTGGTG    c.7920
 M  T  H  L  A  A  A  P  G  T  Q   | V  S  R  E  A  V  A  L  V      p.2640

          .         .         .         .       | 43 .         .    g.45083
 AAGCCGGTGACCAGTGCACCAAGGCCATCCATGGCACCCACTTCAG | CTCTGCCCTCGCGA    c.7980
 K  P  V  T  S  A  P  R  P  S  M  A  P  T  S  A |   L  P  S  R      p.2660

          .         .         .         .         .         .       g.45143
 TCGCTGGAGCCCCCTGAGGAACTCACGCAGACGCGGCTGCACCGCCTCATCAATCCCAAC       c.8040
 S  L  E  P  P  E  E  L  T  Q  T  R  L  H  R  L  I  N  P  N         p.2680

          .         .         .         .         | 44         .    g.45437
 TTCTACGGCTATCAGGACGCCCCCTGGAAGATCTTCCTGCGCAAAGAG | GTGTTTTACCCC    c.8100
 F  Y  G  Y  Q  D  A  P  W  K  I  F  L  R  K  E   | V  F  Y  P      p.2700

          .         .         .         .         | 45         .    g.45986
 AAGGACAGCTACAGCCATCCTGTGCAGCTTGACCTCCTGTTCCGGCAG | ATCCTGCACGAC    c.8160
 K  D  S  Y  S  H  P  V  Q  L  D  L  L  F  R  Q   | I  L  H  D      p.2720

          .         .         .         .         .         .       g.46046
 ACGCTCTCCGAGGCCTGCCTTCGCATCTCTGAGGATGAGAGGCTCAGGATGAAGGCCTTG       c.8220
 T  L  S  E  A  C  L  R  I  S  E  D  E  R  L  R  M  K  A  L         p.2740

      | 46   .         .         .         .         .         .    g.46460
 TTTG | CCCAGAACCAGCTGGACACACAGAAGCCTCTGGTAACGGAAAGCGTGAAGCGGGCC    c.8280
 F  A |   Q  N  Q  L  D  T  Q  K  P  L  V  T  E  S  V  K  R  A      p.2760

          .         .         .         .         .         .       g.46520
 GTGGTCAGCACTGCACGAGACACCTGGGAGGTCTACTTCTCCCGCATCTTCCCCGCCACG       c.8340
 V  V  S  T  A  R  D  T  W  E  V  Y  F  S  R  I  F  P  A  T         p.2780

  | 47       .         .         .         .         .         .    g.46668
  | GGCAGCGTGGGCACTGGTGTGCAGCTCCTAGCTGTGTCCCACGTGGGCATCAAACTCCTG    c.8400
  | G  S  V  G  T  G  V  Q  L  L  A  V  S  H  V  G  I  K  L  L      p.2800

          .         .         .         .         .          | 48    g.47490
 AGGATGGTCAAGGGTGGCCAGGAGGCCGGCGGGCAGCTGCGGGTCCTGCGTGCATACAG | C    c.8460
 R  M  V  K  G  G  Q  E  A  G  G  Q  L  R  V  L  R  A  Y  S  |      p.2820

          .         .         .         .         .         .       g.47550
 TTTGCAGATATCCTGTTTGTGACCATGCCCTCCCAGAACATGCTGGAGTTCAACCTGGCC       c.8520
 F  A  D  I  L  F  V  T  M  P  S  Q  N  M  L  E  F  N  L  A         p.2840

          .         .         .         .         .         .       g.47610
 AGTGAGAAGGTCATCCTCTTCTCAGCCCGAGCGCACCAGGTCAAGACCCTGGTAGATGAC       c.8580
 S  E  K  V  I  L  F  S  A  R  A  H  Q  V  K  T  L  V  D  D         p.2860

          .         .  | 49      .         .         .         .    g.48287
 TTCATCTTGGAGCTGAAGAAG | GACTCTGACTACGTGGTCGCTGTGAGGAACTTCCTGCCT    c.8640
 F  I  L  E  L  K  K   | D  S  D  Y  V  V  A  V  R  N  F  L  P      p.2880

          .         .         .         .         .         .       g.48347
 GAGGACCCTGCGCTGCTGGCTTTCCACAAGGGTGACATCATACACCTGCAGCCCCTAGAG       c.8700
 E  D  P  A  L  L  A  F  H  K  G  D  I  I  H  L  Q  P  L  E         p.2900

          .    | 50    .         .         .         .         .    g.48497
 CCACCTCGAGTGG | GCTACAGTGCTGGCTGCGTGGTTCGCAGGAAGGTGGTGTACCTGGAG    c.8760
 P  P  R  V  G |   Y  S  A  G  C  V  V  R  R  K  V  V  Y  L  E      p.2920

          .         .         | 51         .         .         .    g.49048
 GAGCTGCGACGTAGAGGCCCCGACTTTG | GCTGGAGGTTCGGGACCATCCACGGGCGCGTG    c.8820
 E  L  R  R  R  G  P  D  F  G |   W  R  F  G  T  I  H  G  R  V      p.2940

          .         .         .         .         .         .       g.49108
 GGCCGCTTCCCTTCGGAGCTGGTGCAGCCCGCTGCTGCCCCCGACTTCCTGCAGCTGCCA       c.8880
 G  R  F  P  S  E  L  V  Q  P  A  A  A  P  D  F  L  Q  L  P         p.2960

          .         .         .         .         .         .       g.49168
 ACGGAGCCAGGCCGCGGCCGAGCAGCCGCCGTGGCCGCTGCTGTGGCCTCTGCAGCCGCT       c.8940
 T  E  P  G  R  G  R  A  A  A  V  A  A  A  V  A  S  A  A  A         p.2980

          .         .        | 52.         .         .         .    g.49850
 GCACAGGAGGTGGGCCGCAGGAGAGAG | GGTCCCCCAGTCAGGGCCCGCTCTGCTGACCAT    c.9000
 A  Q  E  V  G  R  R  R  E   | G  P  P  V  R  A  R  S  A  D  H      p.3000

          .         .         .         .         .         .       g.49910
 GGGGAGGACGCCCTGGCGCTCCCACCCTACACAATGCTCGAGTTTGCCCAGAAGTATTTC       c.9060
 G  E  D  A  L  A  L  P  P  Y  T  M  L  E  F  A  Q  K  Y  F         p.3020

          .         .    | 53    .         .         .         .    g.50256
 CGAGACCCTCAGAGGAGACCCCA | GGATGGCCTCAGGCTGAAATCCAAGGAGCCTCGGGAG    c.9120
 R  D  P  Q  R  R  P  Q  |  D  G  L  R  L  K  S  K  E  P  R  E      p.3040

          .         .         .       | 54 .         .         .    g.50593
 TCCAGAACCTTGGAGGACATGCTTTGCTTCACCAAG | ACTCCCCTCCAGGAATCCCTCATC    c.9180
 S  R  T  L  E  D  M  L  C  F  T  K   | T  P  L  Q  E  S  L  I      p.3060

          .         .         .         .          | 55        .    g.50911
 GAACTCAGCGACAGCAGCCTCAGCAAGATGGCCACCGACATGTTCCTAG | CTGTAATGAGG    c.9240
 E  L  S  D  S  S  L  S  K  M  A  T  D  M  F  L  A |   V  M  R      p.3080

          .         .         .         .         .         .       g.50971
 TTCATGGGGGATGCCCCACTGAAGGGCCAGAGTGACCTGGACGTGCTTTGTAACCTCCTG       c.9300
 F  M  G  D  A  P  L  K  G  Q  S  D  L  D  V  L  C  N  L  L         p.3100

     | 56    .         .         .         .         .         .    g.51286
 AAG | CTGTGCGGGGACCATGAGGTCATGCGGGATGAATGTTACTGCCAAGTTGTGAAGCAG    c.9360
 K   | L  C  G  D  H  E  V  M  R  D  E  C  Y  C  Q  V  V  K  Q      p.3120

          .         .       | 57 .         .         .         .    g.52645
 ATCACAGACAATACCAGCTCCAAGCA | GGACAGCTGCCAGCGAGGCTGGAGGCTGCTGTAT    c.9420
 I  T  D  N  T  S  S  K  Q  |  D  S  C  Q  R  G  W  R  L  L  Y      p.3140

          .         .         .         .         .         .       g.52705
 ATCGTGACCGCCTACCACAGCTGCTCTGAGGTCCTCCACCCACACCTCACTCGCTTCCTC       c.9480
 I  V  T  A  Y  H  S  C  S  E  V  L  H  P  H  L  T  R  F  L         p.3160

          .         .         .        | 58.         .         .    g.53902
 CAAGACGTGAGCCGGACCCCAGGCCTGCCCTTTCAGG | GGATCGCCAAGGCCTGCGAGCAG    c.9540
 Q  D  V  S  R  T  P  G  L  P  F  Q  G |   I  A  K  A  C  E  Q      p.3180

          .         .         .         .         .         .       g.53962
 AACCTGCAGAAAACCTTGCGCTTCGGAGGTCGTCTGGAGCTCCCCAGCAGCATAGAGCTT       c.9600
 N  L  Q  K  T  L  R  F  G  G  R  L  E  L  P  S  S  I  E  L         p.3200

          .   | 59     .         .         .         .         .    g.54586
 CGGGCCATGTTG | GCAGGCCGCAGTTCCAAGAGGCAACTCTTTCTTCTTCCTGGAGGCCTT    c.9660
 R  A  M  L   | A  G  R  S  S  K  R  Q  L  F  L  L  P  G  G  L      p.3220

          .         .         . | 60       .         .         .    g.55066
 GAACGCCATCTCAAAATCAAAACATGCACT | GTGGCCCTGGACGTGGTGGAAGAGATATGT    c.9720
 E  R  H  L  K  I  K  T  C  T   | V  A  L  D  V  V  E  E  I  C      p.3240

          .         .         .         .         .         .       g.55126
 GCTGAGATGGCTCTGACACGCCCTGAGGCCTTCAATGAATATGTTATCTTCGTTGTCACC       c.9780
 A  E  M  A  L  T  R  P  E  A  F  N  E  Y  V  I  F  V  V  T         p.3260

         | 61.         .         .         .         .         .    g.57708
 AACCGTG | GCCAGCATGTGTGCCCACTCAGTCGCCGTGCTTACATCCTGGATGTGGCCTCA    c.9840
 N  R  G |   Q  H  V  C  P  L  S  R  R  A  Y  I  L  D  V  A  S      p.3280

          .         .         .         .         .         .       g.57768
 GAGATGGAGCAGGTGGACGGCGGCTACATGCTCTGGTTCCGGCGTGTGCTCTGGGATCAG       c.9900
 E  M  E  Q  V  D  G  G  Y  M  L  W  F  R  R  V  L  W  D  Q         p.3300

          .         .         .         .         | 62         .    g.58896
 CCACTCAAGTTCGAGAATGAGCTATATGTGACCATGCACTACAACCAG | GTCCTGCCTGAC    c.9960
 P  L  K  F  E  N  E  L  Y  V  T  M  H  Y  N  Q   | V  L  P  D      p.3320

          .         .         .         .         .         .       g.58956
 TACCTGAAGGGACTCTTCAGCAGTGTGCCGGCCAGCCGGCCCAGCGAGCAGCTGCTGCAG       c.10020
 Y  L  K  G  L  F  S  S  V  P  A  S  R  P  S  E  Q  L  L  Q         p.3340

          .         .         .         .         .         .       g.59016
 CAGGTGTCCAAGCTGGCTTCACTGCAGCATCGCGCCAAGGACCACTTCTACCTGCCGAGC       c.10080
 Q  V  S  K  L  A  S  L  Q  H  R  A  K  D  H  F  Y  L  P  S         p.3360

    | 63     .         .         .         .         .         .    g.62990
 GT | GCGGGAAGTCCAGGAGTACATCCCAGCCCAGCTCTACCGTACAACGGCAGGCTCGACC    c.10140
 V  |  R  E  V  Q  E  Y  I  P  A  Q  L  Y  R  T  T  A  G  S  T      p.3380

          .         .         .         .         .         .       g.63050
 TGGCTCAACCTGGTCAGCCAGCACCGGCAGCAGACACAGGCGCTCAGCCCCCACCAGGCC       c.10200
 W  L  N  L  V  S  Q  H  R  Q  Q  T  Q  A  L  S  P  H  Q  A         p.3400

          .       | 64 .         .         .         .         .    g.63495
 CGTGCCCAGTTTCTGG | GCCTCCTCAGCGCCTTACCTATGTTCGGCTCCTCCTTCTTCTTC    c.10260
 R  A  Q  F  L  G |   L  L  S  A  L  P  M  F  G  S  S  F  F  F      p.3420

          .         .         .         .         .         .       g.63555
 ATCCAGAGCTGCAGCAACATTGCTGTGCCAGCCCCTTGCATCCTTGCCATCAACCACAAT       c.10320
 I  Q  S  C  S  N  I  A  V  P  A  P  C  I  L  A  I  N  H  N         p.3440

          .         .         . | 65       .         .         .    g.65105
 GGCCTCAACTTTCTCAGCACAGAGACTCAT | GAATTGATGGTGAAGTTCCCCCTGAAGGAG    c.10380
 G  L  N  F  L  S  T  E  T  H   | E  L  M  V  K  F  P  L  K  E      p.3460

          .         .         .         .         .         .       g.65165
 ATCCAGTCGACGCGGACCCAGCGGCCCACGGCCAACTCCAGCTACCCCTATGTGGAGATT       c.10440
 I  Q  S  T  R  T  Q  R  P  T  A  N  S  S  Y  P  Y  V  E  I         p.3480

          .         .         .         .         .  | 66      .    g.70072
 GCGCTGGGGGACGTGGCGGCCCAGCGCACCTTGCAGCTGCAGCTGGAGCAG | GGACTGGAA    c.10500
 A  L  G  D  V  A  A  Q  R  T  L  Q  L  Q  L  E  Q   | G  L  E      p.3500

          .         .         .         .         .         .       g.70132
 CTGTGTCGTGTGGTGGCCGTGCACGTGGAGAACCTGCTCAGTGCCCATGAGAAGCGGCTC       c.10560
 L  C  R  V  V  A  V  H  V  E  N  L  L  S  A  H  E  K  R  L         p.3520

          .         .         .                                     g.70165
 ACATTGCCCCCCAGCGAGATCACCCTGCTCTGA                                  c.10593
 T  L  P  P  S  E  I  T  L  L  X                                    p.3530

          .         .         .         .         .         .       g.70225
 cccagcccccagccctccagtaccttctgccagaagactcactgtgtggcctcagagaaa       c.*60

          .         .         .         .         .         .       g.70285
 tcactgaacctctcaggatcaatgacccctgtaaggggccagagccttggaggacactaa       c.*120

          .         .         .         .         .         .       g.70345
 gaggaggcaggaggagcaactcaaatccccaagaacacaagaagacccatcctgaactgg       c.*180

          .         .         .         .         .         .       g.70405
 gatggaatggcagcatgcaaacttggatcagatagcaggaggaactttcaaaagtctggc       c.*240

          .         .         .         .         .         .       g.70465
 ccactgtgcagtggagcagaaggcaggaccatgaggcctcctgccatgtacccattgcag       c.*300

          .         .         .         .         .         .       g.70525
 accctgcccctaactcctgcctatgacacagaagccccacaccagttgcccagatgaact       c.*360

          .         .         .         .         .         .       g.70585
 ggcctctgcctttggtttactcagggtctgatgttggaatctgctccaactccacaccct       c.*420

          .         .         .         .         .         .       g.70645
 agcccttacatgtcctcctaaggggcccctccttgtgctgccagtcagcctggatttctg       c.*480

          .         .         .         .         .         .       g.70705
 gtctttggttatttctgtgcaaacaaaaggtgtgcctggcagccatttctccatggagtt       c.*540

          .         .         .         .         .         .       g.70765
 gctaagtggccggaaaacaagcctgagggaggaggcaggagttggagttaccttaggccc       c.*600

          .         .         .         .         .         .       g.70825
 ctgattcactgcctatgaacagaccatcccccactccttgggtatccccaaccccagacc       c.*660

          .         .         .         .         .         .       g.70885
 cccatcacttgatgggccacacaagtttgagagtggtacaagggagaagtttgggaaaag       c.*720

          .         .         .         .         .         .       g.70945
 ccttcttggaaaatgggacattagcattgagttttgaaagatgagtaggagtttgctaag       c.*780

          .         .         .         .         .         .       g.71005
 aatagatggaagacagcaggataaacattccagagaaaatcatgtttattccctgctgta       c.*840

          .         .         .         .         .         .       g.71065
 tcttccagaacctaggaggatgcctaacagagagtaagcacttaaaaaatatttgtcata       c.*900

          .         .         .                                     g.71097
 tgaatgaaaaaataaacgagtgaatgttgata                                   c.*932

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The MYO15A myosin XVA protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.2.0 Build 34
©2004-2013 Leiden University Medical Center