phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1) - coding DNA reference sequence

(used for mutation description)

(last modified May 2, 2014)


This file was created to facilitate the description of sequence variants in the PIK3R1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering PIK3R1 transcript NM_181523.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.1040
                     gtcgccagcagctggagcggagttggaggaagcagcggca       c.-541

 .         .         .         .         .         .                g.1100
 gcggcgagggcggcaggctagctgtcggagacggcaagcacggatcgggcacggccggcg       c.-481

 .         .         .         .         .         .                g.1160
 ggtcgcagccgggctggaggccggtcggaaccgagcgggcaggaggccaccgctgcagcg       c.-421

 .         .         .         .    | 02    .         .             g.11560
 cgggccccgcagaggaaggaagccggcgggcggg | gtgaagctcgtgtgtggagtgccacg    c.-361

 .         .         .         .         .         .                g.11620
 gtacaatcagacgacagatggacagtgtgacaaaagtgtcagaaaggattgggcctcgct       c.-301

 .         .         .         .         .         .                g.11680
 gtgagagtcagcctggattcaaagtgttgacaagttgctgaaaaggaagccagtgagagg       c.-241

 .         .         .         .         .         .                g.11740
 actgtggcacgcagaggaagtggagccctgtcttcggtcacaccattgatggaggacaga       c.-181

 .         .         .         .         .         .                g.11800
 tggacagccgtatggccagtcacctctcctcttaaacctttggagagtggtcctttgtcc       c.-121

 .         .         .         .         .         .                g.11860
 tctgctggacacataataggaattctaacacattctctgaattcacttttcataaaaacg       c.-61

 .         .         .         .         .         .                g.11920
 taaaatcagactgctctgtacaaccaggctcaactgttgcatggtagcagatttgcaaac       c.-1

          .         .         .         .         .         .       g.11980
 ATGAGTGCTGAGGGGTACCAGTACAGAGCGCTGTATGATTATAAAAAGGAAAGAGAAGAA       c.60
 M  S  A  E  G  Y  Q  Y  R  A  L  Y  D  Y  K  K  E  R  E  E         p.20

          .         .         .         .         .         .       g.12040
 GATATTGACTTGCACTTGGGTGACATATTGACTGTGAATAAAGGGTCCTTAGTAGCTCTT       c.120
 D  I  D  L  H  L  G  D  I  L  T  V  N  K  G  S  L  V  A  L         p.40

          .         .         .         .         .         .       g.12100
 GGATTCAGTGATGGACAGGAAGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAAT       c.180
 G  F  S  D  G  Q  E  A  R  P  E  E  I  G  W  L  N  G  Y  N         p.60

          .         .         .         .         .         .       g.12160
 GAAACCACAGGGGAAAGGGGGGACTTTCCGGGAACTTACGTAGAATATATTGGAAGGAAA       c.240
 E  T  T  G  E  R  G  D  F  P  G  T  Y  V  E  Y  I  G  R  K         p.80

          .         .         .         .         .         .       g.12220
 AAAATCTCGCCTCCCACACCAAAGCCCCGGCCACCTCGGCCTCTTCCTGTTGCACCAGGT       c.300
 K  I  S  P  P  T  P  K  P  R  P  P  R  P  L  P  V  A  P  G         p.100

          .         .         .     | 03   .         .         .    g.58660
 TCTTCGAAAACTGAAGCAGATGTTGAACAACAAG | CTTTGACTCTCCCGGATCTTGCAGAG    c.360
 S  S  K  T  E  A  D  V  E  Q  Q  A |   L  T  L  P  D  L  A  E      p.120

          .         .         .         .         .         .       g.58720
 CAGTTTGCCCCTCCTGACATTGCCCCGCCTCTTCTTATCAAGCTCGTGGAAGCCATTGAA       c.420
 Q  F  A  P  P  D  I  A  P  P  L  L  I  K  L  V  E  A  I  E         p.140

         | 04.         .         .         .         .         .    g.59236
 AAGAAAG | GTCTGGAATGTTCAACTCTATACAGAACACAGAGCTCCAGCAACCTGGCAGAA    c.480
 K  K  G |   L  E  C  S  T  L  Y  R  T  Q  S  S  S  N  L  A  E      p.160

          .         .   | 05     .         .         .         .    g.64884
 TTACGACAGCTTCTTGATTGTG | ATACACCCTCCGTGGACTTGGAAATGATCGATGTGCAC    c.540
 L  R  Q  L  L  D  C  D |   T  P  S  V  D  L  E  M  I  D  V  H      p.180

          .         .         .         .         .         .       g.64944
 GTTTTGGCTGACGCTTTCAAACGCTATCTCCTGGACTTACCAAATCCTGTCATTCCAGCA       c.600
 V  L  A  D  A  F  K  R  Y  L  L  D  L  P  N  P  V  I  P  A         p.200

          .         .         .     | 06   .         .         .    g.65798
 GCCGTTTACAGTGAAATGATTTCTTTAGCTCCAG | AAGTACAAAGCTCCGAAGAATATATT    c.660
 A  V  Y  S  E  M  I  S  L  A  P  E |   V  Q  S  S  E  E  Y  I      p.220

          .         .         .         .         .         .       g.65858
 CAGCTATTGAAGAAGCTTATTAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTT       c.720
 Q  L  L  K  K  L  I  R  S  P  S  I  P  H  Q  Y  W  L  T  L         p.240

          .         .         .         .         .         .       g.65918
 CAGTATTTGTTAAAACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAAAATCTGTTGAAT       c.780
 Q  Y  L  L  K  H  F  F  K  L  S  Q  T  S  S  K  N  L  L  N         p.260

          .         .         .         .         .       | 07 .    g.66175
 GCAAGAGTACTCTCTGAAATTTTCAGCCCTATGCTTTTCAGATTCTCAGCAGCCAG | CTCT    c.840
 A  R  V  L  S  E  I  F  S  P  M  L  F  R  F  S  A  A  S  |  S      p.280

          .         .         .         .         .         .       g.66235
 GATAATACTGAAAACCTCATAAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAA       c.900
 D  N  T  E  N  L  I  K  V  I  E  I  L  I  S  T  E  W  N  E         p.300

          .       | 08 .         .         .         .         .    g.77547
 CGACAGCCTGCACCAG | CACTGCCTCCTAAACCACCAAAACCTACTACTGTAGCCAACAAC    c.960
 R  Q  P  A  P  A |   L  P  P  K  P  P  K  P  T  T  V  A  N  N      p.320

          .         .         .         .         .          | 09    g.78346
 GGTATGAATAACAATATGTCCTTACAAGATGCTGAATGGTACTGGGGAGATATCTCGAG | G    c.1020
 G  M  N  N  N  M  S  L  Q  D  A  E  W  Y  W  G  D  I  S  R  |      p.340

          .         .         .         .         .         .       g.78406
 GAAGAAGTGAATGAAAAACTTCGAGATACAGCAGACGGGACCTTTTTGGTACGAGATGCG       c.1080
 E  E  V  N  E  K  L  R  D  T  A  D  G  T  F  L  V  R  D  A         p.360

          .         .         .         | 10         .         .    g.78569
 TCTACTAAAATGCATGGTGATTATACTCTTACACTAAG | GAAAGGGGGAAATAACAAATTA    c.1140
 S  T  K  M  H  G  D  Y  T  L  T  L  R  |  K  G  G  N  N  K  L      p.380

          .         .         .         .         .         .       g.78629
 ATCAAAATATTTCATCGAGATGGGAAATATGGCTTCTCTGACCCATTAACCTTCAGTTCT       c.1200
 I  K  I  F  H  R  D  G  K  Y  G  F  S  D  P  L  T  F  S  S         p.400

          .         .         .         .         .         .       g.78689
 GTGGTTGAATTAATAAACCACTACCGGAATGAATCTCTAGCTCAGTATAATCCCAAATTG       c.1260
 V  V  E  L  I  N  H  Y  R  N  E  S  L  A  Q  Y  N  P  K  L         p.420

          .         .         .          | 11        .         .    g.78974
 GATGTGAAATTACTTTATCCAGTATCCAAATACCAACAG | GATCAAGTTGTCAAAGAAGAT    c.1320
 D  V  K  L  L  Y  P  V  S  K  Y  Q  Q   | D  Q  V  V  K  E  D      p.440

          .         .         .         .         .         .       g.79034
 AATATTGAAGCTGTAGGGAAAAAATTACATGAATATAACACTCAGTTTCAAGAAAAAAGT       c.1380
 N  I  E  A  V  G  K  K  L  H  E  Y  N  T  Q  F  Q  E  K  S         p.460

          .         .         .         .      | 12  .         .    g.79795
 CGAGAATATGATAGATTATATGAAGAATATACCCGCACATCCCAG | GAAATCCAAATGAAA    c.1440
 R  E  Y  D  R  L  Y  E  E  Y  T  R  T  S  Q   | E  I  Q  M  K      p.480

          .         .         .         .         .         .       g.79855
 AGGACAGCTATTGAAGCATTTAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACC       c.1500
 R  T  A  I  E  A  F  N  E  T  I  K  I  F  E  E  Q  C  Q  T         p.500

          .         .         .         .         .         .       g.79915
 CAAGAGCGGTACAGCAAAGAATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAAGAA       c.1560
 Q  E  R  Y  S  K  E  Y  I  E  K  F  K  R  E  G  N  E  K  E         p.520

          | 13         .         .         .         .         .    g.80444
 ATACAAAG | GATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGAC    c.1620
 I  Q  R  |  I  M  H  N  Y  D  K  L  K  S  R  I  S  E  I  I  D      p.540

          .         .         .         .         .         .       g.80504
 AGTAGAAGAAGATTGGAAGAAGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGAC       c.1680
 S  R  R  R  L  E  E  D  L  K  K  Q  A  A  E  Y  R  E  I  D         p.560

          .         .         .         .         .         .       g.80564
 AAACGTATGAACAGCATTAAACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAATAC       c.1740
 K  R  M  N  S  I  K  P  D  L  I  Q  L  R  K  T  R  D  Q  Y         p.580

       | 14  .         .         .         .         .         .    g.80719
 TTGAT | GTGGTTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAAT    c.1800
 L  M  |  W  L  T  Q  K  G  V  R  Q  K  K  L  N  E  W  L  G  N      p.600

          .     | 15   .         .         .         .         .    g.81461
 GAAAACACTGAAGA | CCAATATTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGAT    c.1860
 E  N  T  E  D  |  Q  Y  S  L  V  E  D  D  E  D  L  P  H  H  D      p.620

          .         .         .         .         .         .       g.81521
 GAGAAGACATGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGAGGG       c.1920
 E  K  T  W  N  V  G  S  S  N  R  N  K  A  E  N  L  L  R  G         p.640

          .         .         .         .         .         .       g.81581
 AAGCGAGATGGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCT       c.1980
 K  R  D  G  T  F  L  V  R  E  S  S  K  Q  G  C  Y  A  C  S         p.660

       | 16  .         .         .         .         .         .    g.82711
 GTAGT | GGTGGACGGCGAAGTAAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGC    c.2040
 V  V  |  V  D  G  E  V  K  H  C  V  I  N  K  T  A  T  G  Y  G      p.680

          .         .         .         .         .         .       g.82771
 TTTGCCGAGCCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAACAC       c.2100
 F  A  E  P  Y  N  L  Y  S  S  L  K  E  L  V  L  H  Y  Q  H         p.700

          .         .         .         .         .         .       g.82831
 ACCTCCCTTGTGCAGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCA       c.2160
 T  S  L  V  Q  H  N  D  S  L  N  V  T  L  A  Y  P  V  Y  A         p.720

          .                                                         g.82846
 CAGCAGAGGCGATGA                                                    c.2175
 Q  Q  R  R  X                                                      p.724

          .         .         .         .         .         .       g.82906
 agcgcttactctttgatccttctcctgaagttcagccaccctgaggcctctggaaagcaa       c.*60

          .         .         .         .         .         .       g.82966
 agggctcctctccagtctgatctgtgaattgagctgcagaaacgaagccatctttctttg       c.*120

          .         .         .         .         .         .       g.83026
 gatgggactagagctttctttcacaaaaaagaagtaggggaagacatgcagcctaaggct       c.*180

          .         .         .         .         .         .       g.83086
 gtatgatgaccacacgttcctaagctggagtgcttatcccttctttttctttttttcttt       c.*240

          .         .         .         .         .         .       g.83146
 ggtttaatttaaagccacaaccacatacaacacaaagagaaaaagaaatgcaaaaatctc       c.*300

          .         .         .         .         .         .       g.83206
 tgcgtgcagggacaaagaggcctttaaccatggtgcttgttaatgctttctgaagcttta       c.*360

          .         .         .         .         .         .       g.83266
 ccagctgaaagttgggactctggagagcggaggagagagaggcagaagaaccctggcctg       c.*420

          .         .         .         .         .         .       g.83326
 agaaggtttggtccagcctggtttagcctggatgttgctgtgcacggtggacccagacac       c.*480

          .         .         .         .         .         .       g.83386
 atcgcactgtggattatttcattttgtaacaaatgaacgatatgtagcagaaaggcacgt       c.*540

          .         .         .         .         .         .       g.83446
 ccactcacaagggacgctttgggagaatgtcagttcatgtatgttcagaagaaattctgt       c.*600

          .         .         .         .         .         .       g.83506
 catagaaagtgccagaaagtgtttaacttgtcaaaaaacaaaaacccagcaacagaaaaa       c.*660

          .         .         .         .         .         .       g.83566
 tggagtttggaaaacaggacttaaaatgacattcagtatataaaatatgtacataatatt       c.*720

          .         .         .         .         .         .       g.83626
 ggatgactaactatcaaatagatggatttgtatcaataccaaatagcttctgttttgttt       c.*780

          .         .         .         .         .         .       g.83686
 tgctgaaggctaaattcacagcgctatgcaattcttaattttcattaagttgttatttca       c.*840

          .         .         .         .         .         .       g.83746
 gttttaaatgtaccttcagaataagcttccccaccccagtttttgttgcttgaaaatatt       c.*900

          .         .         .         .         .         .       g.83806
 gttgtcccggatttttgttaatattcatttttgttatccttttttaaaagtaaatgtaca       c.*960

          .         .         .         .         .         .       g.83866
 ggatgccagtaaaaaaaaaaaatggcttcagaattaaaactatgaaatattttacagttt       c.*1020

          .         .         .         .         .         .       g.83926
 ttcttgtacagagtacttggctgttagcccaaggttaaaaagttcataacagattttttt       c.*1080

          .         .         .         .         .         .       g.83986
 tggactgttttgttgggcagtgcctgataagcttcaaagctgctttattcaataaaaaaa       c.*1140

          .         .         .         .         .         .       g.84046
 agaaatgaaaaagatatatgaatatgacaaagtattgctgagtccaacaatgttgtttta       c.*1200

          .         .         .         .         .         .       g.84106
 agactcttaaaatacggtacctggcaatgtttatttcataaagaattgtgaacttcttga       c.*1260

          .         .         .         .         .         .       g.84166
 atctagggagggggaatgtagtgaagggatgtatcaagtggggtggtgggagggggaggc       c.*1320

          .         .         .         .         .         .       g.84226
 aaggttatatgcactttctcatgatttacagagaagtgaataactgcaaagtgaagttgc       c.*1380

          .         .         .         .         .         .       g.84286
 ttcttctacttcagtcttctctcactttgatttgctagttgttatcaattaatgacaatt       c.*1440

          .         .         .         .         .         .       g.84346
 acaaacctactgtatctctaatacagtgtgactggtcaggtatttcagttcttaggaagg       c.*1500

          .         .         .         .         .         .       g.84406
 aagtgccaagtttgtttttgggttcctggaacagcgctcacctttgtttagaacactggt       c.*1560

          .         .         .         .         .         .       g.84466
 ttaaagggataatcatctctgtcacattagactatccatcatgaccagcaaatactcatt       c.*1620

          .         .         .         .         .         .       g.84526
 ttaggaaaaaaaaaagcatgatctgaaaaatacttttggtggtatgttggttaccctcct       c.*1680

          .         .         .         .         .         .       g.84586
 agctttccatttggtttagaacataaagcaaatagacacagtcatactgtcactgctctg       c.*1740

          .         .         .         .         .         .       g.84646
 gactgtgtggagctcgctaaagtcatggtcattgcaggaatccaagtggcagtccttctc       c.*1800

          .         .         .         .         .         .       g.84706
 attcattctaatcattgtatgtgcttcactacgggggggagaaggaaacgttagcatcat       c.*1860

          .         .         .         .         .         .       g.84766
 gtttcccatttagggcaggagtgagaggtctctcttcctgatttagatatgcaaaagctg       c.*1920

          .         .         .         .         .         .       g.84826
 gtatgttcagtaggaactgtacatgtgttgggaggcataaagactaattagcaaccataa       c.*1980

          .         .         .         .         .         .       g.84886
 tatggtcactaccctaatagactaaatgaaatcttgcaatttcaaattactctttctcca       c.*2040

          .         .         .         .         .         .       g.84946
 tattagatttacccacagctatatttctgtttaagtactagggtgagggttttctgttac       c.*2100

          .         .         .         .         .         .       g.85006
 tttgttttttaatgttgttccttttgaaagaatcagtcttgcagctgagtgaaaaatctg       c.*2160

          .         .         .         .         .         .       g.85066
 tggaatgtattatttgtcctctttacatgaaactactcatacttaagcaaaagtcagtct       c.*2220

          .         .         .         .         .         .       g.85126
 tatagcaagactgttagccctcaaacttgactctactgatctgaccatttccctctcatc       c.*2280

          .         .         .         .         .         .       g.85186
 gccagacaactgacgatttccctggttttagtctgcgtctctgctttaaagttattgtga       c.*2340

          .         .         .         .         .         .       g.85246
 tatccttctagatcatacacaagtctaacagttaattagttaacagtttttaaactaggt       c.*2400

          .         .         .         .         .         .       g.85306
 ttgtgggtatttttttggtagcacatgtatgctattacatacaaatttttatttctaaaa       c.*2460

          .         .         .         .         .         .       g.85366
 tataagatctgagattgaatattttcattaaaagctacagttttgtgaatctttgtgctt       c.*2520

          .         .         .         .         .         .       g.85426
 caacattctttgcaagatgatacggtatttaggcatttgccttatttttgcatctcacaa       c.*2580

          .         .         .         .         .         .       g.85486
 acataagtgcaatagatcttttcattgaacagcaaagtaggattcatcattccatatgac       c.*2640

          .         .         .         .         .         .       g.85546
 ttgagttacaccagacctgttctgcccaatgcctttttgattacagtgtagcttgcccac       c.*2700

          .         .         .         .         .         .       g.85606
 cgcatttgtcgttttagatactttgctagccggccactttggatttcatcagacagtcct       c.*2760

          .         .         .         .         .         .       g.85666
 aacaatattgtctgaacggctgaatatgaatagatacagcagaggcactcctgatatatg       c.*2820

          .         .         .         .         .         .       g.85726
 atttttatccatgcgtcagtttttcccacccagtgtagcatcctaaagataaagccagaa       c.*2880

          .         .         .         .         .         .       g.85786
 gctaagctgcagtgaggctgtgattgggcgtagaagtgggagcattgggacctcacatta       c.*2940

          .         .         .         .         .         .       g.85846
 cacacacgagagatcataaccatgtgaaaaggcaaaaagcatgtgtttgcaacatctgat       c.*3000

          .         .         .         .         .         .       g.85906
 aacttcatggcctttgataaatgtatatatgtatatgtgcatggactgtgtttccagtac       c.*3060

          .         .         .         .         .         .       g.85966
 acctttcagccaaaacagatccacagtagttgttgagttcaagtacataaagtacataac       c.*3120

          .         .         .         .         .         .       g.86026
 aagcgaacgtctagtacaattcttacttatgtgtatgggatttttccctttgaggttgct       c.*3180

          .         .         .         .         .         .       g.86086
 ttgttttgtcttacaaaggtgaaaattgtttgtaagtgaagtgagaagttcatatttctt       c.*3240

          .         .         .         .         .         .       g.86146
 tggcttttttgtgtttttaaaagttactccttttagggagctggtctgatgacttgctta       c.*3300

          .         .         .         .         .         .       g.86206
 gcttggaaatccttgttttcagtgtgtcgagtcaaaatgtgtttatgtgagctgtcactg       c.*3360

          .         .         .         .         .         .       g.86266
 tggggaaccaattgctttgtcatatagctggttatgaactagtaacatgtttgggaagtc       c.*3420

          .         .         .         .         .         .       g.86326
 ctactgatgttcctttggaagaaaaaatctgctggttttaacaactgtgcttttgctatg       c.*3480

          .         .         .         .         .         .       g.86386
 tatggtatccaagttagttgaaacgcagacactgagatctgtttgagtttagggtcattt       c.*3540

          .         .         .         .         .         .       g.86446
 ttagaaaggggcagtttaaagcacaatgtctcacatgggacaaagttccaaaatgccaaa       c.*3600

          .         .         .         .         .         .       g.86506
 ttcttattttttaaaaagctagttctataaaatactggtattatgggtggggaggaaata       c.*3660

          .         .         .         .         .         .       g.86566
 gaattgagtcaattggaaagactatccaacttaacatgaaacttgtcaccatgagatagc       c.*3720

          .         .         .         .         .         .       g.86626
 attagctgcccaggatgctgctatatatatatatatatatatatatgtgtgtgtgtgtgt       c.*3780

          .         .         .         .         .         .       g.86686
 gtgtgtgtgtgtatatatatatatatatatatatatatatatatatatatatgtgtgtgt       c.*3840

          .         .         .         .         .         .       g.86746
 atatatatatatatgtgtatatatatatgtatatacatatatgtatatatatgcacatat       c.*3900

          .         .         .         .         .         .       g.86806
 atatatgtatttaaaaaaatcaaaacaaaaaaaaactcatttatacctgtgtatttttta       c.*3960

          .         .         .         .         .         .       g.86866
 aagctacaatctgttcaatgtttttaaaaatctgtttatatgacattgttaaaataaagt       c.*4020

          .         .         .         .         .         .       g.86926
 tggtcttttgacgagagggaggatgtcacggtcagttgtaactttgccttcacaaggcaa       c.*4080

          .         .         .         .         .         .       g.86986
 ctggggtggggggtgggggtagtgtgcctccttgacatttcgttcaagttatagattcaa       c.*4140

          .         .         .         .         .         .       g.87046
 tggagctatgtcttgttttaagttgctttaatgcattgtattagatcttcaaacagaata       c.*4200

          .         .                                               g.87066
 aaggttgttttgaaactgaa                                               c.*4220

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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