(intronic numbering for coding DNA Reference Sequence)
         .         .         .         .       g.12462
gtaagctgtccttggcctcagtatcctcttctgtgcccctccctt  c.582+45
--------------------- middle of intron ---------------------
      g.12463       .         .         .         .           g.12506
      c.583-44  gcctcaccctgcccagtcgggctcacagcaccctctgctcccag  c.583-1
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