toll-like receptor 3 (TLR3) - coding DNA reference sequence

(used for mutation description)

(last modified May 1, 2014)


This file was created to facilitate the description of sequence variants in the TLR3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering TLR3 transcript NM_003265.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.1041
                    cactttcgagagtgccgtctatttgccacacacttccctga       c.-61

 .         .         .         .         .         .   | 02         g.8465
 tgaaatgtctggatttggactaaagaaaaaaggaaaggctagcagtcatccaa | cagaatc    c.-1

          .         .         .         .         .         .       g.8525
 ATGAGACAGACTTTGCCTTGTATCTACTTTTGGGGGGGCCTTTTGCCCTTTGGGATGCTG       c.60
 M  R  Q  T  L  P  C  I  Y  F  W  G  G  L  L  P  F  G  M  L         p.20

          .         .         .         .         .         .       g.8585
 TGTGCATCCTCCACCACCAAGTGCACTGTTAGCCATGAAGTTGCTGACTGCAGCCACCTG       c.120
 C  A  S  S  T  T  K  C  T  V  S  H  E  V  A  D  C  S  H  L         p.40

          .         .         .         .         .         .       g.8645
 AAGTTGACTCAGGTACCCGATGATCTACCCACAAACATAACAGTGTTGAACCTTACCCAT       c.180
 K  L  T  Q  V  P  D  D  L  P  T  N  I  T  V  L  N  L  T  H         p.60

          .         .         .         .         .         .       g.8705
 AATCAACTCAGAAGATTACCAGCCGCCAACTTCACAAGGTATAGCCAGCTAACTAGCTTG       c.240
 N  Q  L  R  R  L  P  A  A  N  F  T  R  Y  S  Q  L  T  S  L         p.80

          .         .         .         .         .         .       g.8765
 GATGTAGGATTTAACACCATCTCAAAACTGGAGCCAGAATTGTGCCAGAAACTTCCCATG       c.300
 D  V  G  F  N  T  I  S  K  L  E  P  E  L  C  Q  K  L  P  M         p.100

          .         .         .         .         .         .       g.8825
 TTAAAAGTTTTGAACCTCCAGCACAATGAGCTATCTCAACTTTCTGATAAAACCTTTGCC       c.360
 L  K  V  L  N  L  Q  H  N  E  L  S  Q  L  S  D  K  T  F  A         p.120

          .         .         .         .         .         .       g.8885
 TTCTGCACGAATTTGACTGAACTCCATCTCATGTCCAACTCAATCCAGAAAATTAAAAAT       c.420
 F  C  T  N  L  T  E  L  H  L  M  S  N  S  I  Q  K  I  K  N         p.140

          .         .  | 03      .         .         .         .    g.10724
 AATCCCTTTGTCAAGCAGAAG | AATTTAATCACATTAGATCTGTCTCATAATGGCTTGTCA    c.480
 N  P  F  V  K  Q  K   | N  L  I  T  L  D  L  S  H  N  G  L  S      p.160

          .         .         .         .         .         .       g.10784
 TCTACAAAATTAGGAACTCAGGTTCAGCTGGAAAATCTCCAAGAGCTTCTATTATCAAAC       c.540
 S  T  K  L  G  T  Q  V  Q  L  E  N  L  Q  E  L  L  L  S  N         p.180

          .         .         .         .         .         .       g.10844
 AATAAAATTCAAGCGCTAAAAAGTGAAGAACTGGATATCTTTGCCAATTCATCTTTAAAA       c.600
 N  K  I  Q  A  L  K  S  E  E  L  D  I  F  A  N  S  S  L  K         p.200

          .         .         .    | 04    .         .         .    g.14192
 AAATTAGAGTTGTCATCGAATCAAATTAAAGAG | TTTTCTCCAGGGTGTTTTCACGCAATT    c.660
 K  L  E  L  S  S  N  Q  I  K  E   | F  S  P  G  C  F  H  A  I      p.220

          .         .         .         .         .         .       g.14252
 GGAAGATTATTTGGCCTCTTTCTGAACAATGTCCAGCTGGGTCCCAGCCTTACAGAGAAG       c.720
 G  R  L  F  G  L  F  L  N  N  V  Q  L  G  P  S  L  T  E  K         p.240

          .         .         .         .         .         .       g.14312
 CTATGTTTGGAATTAGCAAACACAAGCATTCGGAATCTGTCTCTGAGTAACAGCCAGCTG       c.780
 L  C  L  E  L  A  N  T  S  I  R  N  L  S  L  S  N  S  Q  L         p.260

          .         .         .         .         .         .       g.14372
 TCCACCACCAGCAATACAACTTTCTTGGGACTAAAGTGGACAAATCTCACTATGCTCGAT       c.840
 S  T  T  S  N  T  T  F  L  G  L  K  W  T  N  L  T  M  L  D         p.280

          .         .         .         .         .         .       g.14432
 CTTTCCTACAACAACTTAAATGTGGTTGGTAACGATTCCTTTGCTTGGCTTCCACAACTA       c.900
 L  S  Y  N  N  L  N  V  V  G  N  D  S  F  A  W  L  P  Q  L         p.300

          .         .         .         .         .         .       g.14492
 GAATATTTCTTCCTAGAGTATAATAATATACAGCATTTGTTTTCTCACTCTTTGCACGGG       c.960
 E  Y  F  F  L  E  Y  N  N  I  Q  H  L  F  S  H  S  L  H  G         p.320

          .         .         .         .         .         .       g.14552
 CTTTTCAATGTGAGGTACCTGAATTTGAAACGGTCTTTTACTAAACAAAGTATTTCCCTT       c.1020
 L  F  N  V  R  Y  L  N  L  K  R  S  F  T  K  Q  S  I  S  L         p.340

          .         .         .         .         .         .       g.14612
 GCCTCACTCCCCAAGATTGATGATTTTTCTTTTCAGTGGCTAAAATGTTTGGAGCACCTT       c.1080
 A  S  L  P  K  I  D  D  F  S  F  Q  W  L  K  C  L  E  H  L         p.360

          .         .         .         .         .         .       g.14672
 AACATGGAAGATAATGATATTCCAGGCATAAAAAGCAATATGTTCACAGGATTGATAAAC       c.1140
 N  M  E  D  N  D  I  P  G  I  K  S  N  M  F  T  G  L  I  N         p.380

          .         .         .         .         .         .       g.14732
 CTGAAATACTTAAGTCTATCCAACTCCTTTACAAGTTTGCGAACTTTGACAAATGAAACA       c.1200
 L  K  Y  L  S  L  S  N  S  F  T  S  L  R  T  L  T  N  E  T         p.400

          .         .         .         .         .         .       g.14792
 TTTGTATCACTTGCTCATTCTCCCTTACACATACTCAACCTAACCAAGAATAAAATCTCA       c.1260
 F  V  S  L  A  H  S  P  L  H  I  L  N  L  T  K  N  K  I  S         p.420

          .         .         .         .         .         .       g.14852
 AAAATAGAGAGTGATGCTTTCTCTTGGTTGGGCCACCTAGAAGTACTTGACCTGGGCCTT       c.1320
 K  I  E  S  D  A  F  S  W  L  G  H  L  E  V  L  D  L  G  L         p.440

          .         .         .         .         .         .       g.14912
 AATGAAATTGGGCAAGAACTCACAGGCCAGGAATGGAGAGGTCTAGAAAATATTTTCGAA       c.1380
 N  E  I  G  Q  E  L  T  G  Q  E  W  R  G  L  E  N  I  F  E         p.460

          .         .         .         .         .         .       g.14972
 ATCTATCTTTCCTACAACAAGTACCTGCAGCTGACTAGGAACTCCTTTGCCTTGGTCCCA       c.1440
 I  Y  L  S  Y  N  K  Y  L  Q  L  T  R  N  S  F  A  L  V  P         p.480

          .         .         .         .         .         .       g.15032
 AGCCTTCAACGACTGATGCTCCGAAGGGTGGCCCTTAAAAATGTGGATAGCTCTCCTTCA       c.1500
 S  L  Q  R  L  M  L  R  R  V  A  L  K  N  V  D  S  S  P  S         p.500

          .         .         .         .         .         .       g.15092
 CCATTCCAGCCTCTTCGTAACTTGACCATTCTGGATCTAAGCAACAACAACATAGCCAAC       c.1560
 P  F  Q  P  L  R  N  L  T  I  L  D  L  S  N  N  N  I  A  N         p.520

          .         .         .         .         .         .       g.15152
 ATAAATGATGACATGTTGGAGGGTCTTGAGAAACTAGAAATTCTCGATTTGCAGCATAAC       c.1620
 I  N  D  D  M  L  E  G  L  E  K  L  E  I  L  D  L  Q  H  N         p.540

          .         .         .         .         .         .       g.15212
 AACTTAGCACGGCTCTGGAAACACGCAAACCCTGGTGGTCCCATTTATTTCCTAAAGGGT       c.1680
 N  L  A  R  L  W  K  H  A  N  P  G  G  P  I  Y  F  L  K  G         p.560

          .         .         .         .         .         .       g.15272
 CTGTCTCACCTCCACATCCTTAACTTGGAGTCCAACGGCTTTGACGAGATCCCAGTTGAG       c.1740
 L  S  H  L  H  I  L  N  L  E  S  N  G  F  D  E  I  P  V  E         p.580

          .         .         .         .         .         .       g.15332
 GTCTTCAAGGATTTATTTGAACTAAAGATCATCGATTTAGGATTGAATAATTTAAACACA       c.1800
 V  F  K  D  L  F  E  L  K  I  I  D  L  G  L  N  N  L  N  T         p.600

          .         .         .         .         .         .       g.15392
 CTTCCAGCATCTGTCTTTAATAATCAGGTGTCTCTAAAGTCATTGAACCTTCAGAAGAAT       c.1860
 L  P  A  S  V  F  N  N  Q  V  S  L  K  S  L  N  L  Q  K  N         p.620

          .         .         .         .         .         .       g.15452
 CTCATAACATCCGTTGAGAAGAAGGTTTTCGGGCCAGCTTTCAGGAACCTGACTGAGTTA       c.1920
 L  I  T  S  V  E  K  K  V  F  G  P  A  F  R  N  L  T  E  L         p.640

          .         .         .         .         .         .       g.15512
 GATATGCGCTTTAATCCCTTTGATTGCACGTGTGAAAGTATTGCCTGGTTTGTTAATTGG       c.1980
 D  M  R  F  N  P  F  D  C  T  C  E  S  I  A  W  F  V  N  W         p.660

          .         .         .         .         .         .       g.15572
 ATTAACGAGACCCATACCAACATCCCTGAGCTGTCAAGCCACTACCTTTGCAACACTCCA       c.2040
 I  N  E  T  H  T  N  I  P  E  L  S  S  H  Y  L  C  N  T  P         p.680

          .         .         .         .         .         .       g.15632
 CCTCACTATCATGGGTTCCCAGTGAGACTTTTTGATACATCATCTTGCAAAGACAGTGCC       c.2100
 P  H  Y  H  G  F  P  V  R  L  F  D  T  S  S  C  K  D  S  A         p.700

          .         .         .         .         .         .       g.15692
 CCCTTTGAACTCTTTTTCATGATCAATACCAGTATCCTGTTGATTTTTATCTTTATTGTA       c.2160
 P  F  E  L  F  F  M  I  N  T  S  I  L  L  I  F  I  F  I  V         p.720

          .         .         .         .         .         .       g.15752
 CTTCTCATCCACTTTGAGGGCTGGAGGATATCTTTTTATTGGAATGTTTCAGTACATCGA       c.2220
 L  L  I  H  F  E  G  W  R  I  S  F  Y  W  N  V  S  V  H  R         p.740

          .         .         .         .         .         .       g.15812
 GTTCTTGGTTTCAAAGAAATAGACAGACAGACAGAACAGTTTGAATATGCAGCATATATA       c.2280
 V  L  G  F  K  E  I  D  R  Q  T  E  Q  F  E  Y  A  A  Y  I         p.760

          .         .         .         .         .         .       g.15872
 ATTCATGCCTATAAAGATAAGGATTGGGTCTGGGAACATTTCTCTTCAATGGAAAAGGAA       c.2340
 I  H  A  Y  K  D  K  D  W  V  W  E  H  F  S  S  M  E  K  E         p.780

          .         .         .         .         .         .       g.15932
 GACCAATCTCTCAAATTTTGTCTGGAAGAAAGGGACTTTGAGGCGGGTGTTTTTGAACTA       c.2400
 D  Q  S  L  K  F  C  L  E  E  R  D  F  E  A  G  V  F  E  L         p.800

          .         .         .         .         .         .       g.15992
 GAAGCAATTGTTAACAGCATCAAAAGAAGCAGAAAAATTATTTTTGTTATAACACACCAT       c.2460
 E  A  I  V  N  S  I  K  R  S  R  K  I  I  F  V  I  T  H  H         p.820

          .         .       | 05 .         .         .         .    g.16524
 CTATTAAAAGACCCATTATGCAAAAG | ATTCAAGGTACATCATGCAGTTCAACAAGCTATT    c.2520
 L  L  K  D  P  L  C  K  R  |  F  K  V  H  H  A  V  Q  Q  A  I      p.840

          .         .         .         .         .         .       g.16584
 GAACAAAATCTGGATTCCATTATATTGGTTTTCCTTGAGGAGATTCCAGATTATAAACTG       c.2580
 E  Q  N  L  D  S  I  I  L  V  F  L  E  E  I  P  D  Y  K  L         p.860

          .         .         .         .         .         .       g.16644
 AACCATGCACTCTGTTTGCGAAGAGGAATGTTTAAATCTCACTGCATCTTGAACTGGCCA       c.2640
 N  H  A  L  C  L  R  R  G  M  F  K  S  H  C  I  L  N  W  P         p.880

          .         .         .         .         .         .       g.16704
 GTTCAGAAAGAACGGATAGGTGCCTTTCGTCATAAATTGCAAGTAGCACTTGGATCCAAA       c.2700
 V  Q  K  E  R  I  G  A  F  R  H  K  L  Q  V  A  L  G  S  K         p.900

          .                                                         g.16719
 AACTCTGTACATTAA                                                    c.2715
 N  S  V  H  X                                                      p.904

          .         .         .         .         .         .       g.16779
 atttatttaaatattcaattagcaaaggagaaactttctcaatttaaaaagttctatggc       c.*60

          .         .         .         .         .         .       g.16839
 aaatttaagttttccataaaggtgttataatttgtttattcatatttgtaaatgattata       c.*120

          .         .         .         .         .         .       g.16899
 ttctatcacaattacatctcttctaggaaaatgtgtctccttatttcaggcctatttttg       c.*180

          .         .         .         .                           g.16944
 acaattgacttaattttacccaaaataaaacatataagcacgtaa                      c.*225

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Toll-like receptor 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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