tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS) - coding DNA reference sequence

(used for mutation description)

(last modified May 1, 2014)


This file was created to facilitate the description of sequence variants in the TNKS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering TNKS transcript NM_003747.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.1694
                                                        cgaag       c.-1

          .         .         .         .         .         .       g.1754
 ATGGCGGCGTCGCGTCGCTCTCAGCATCATCACCACCATCATCAACAACAGCTCCAGCCC       c.60
 M  A  A  S  R  R  S  Q  H  H  H  H  H  H  Q  Q  Q  L  Q  P         p.20

          .         .         .         .         .         .       g.1814
 GCCCCAGGGGCTTCAGCGCCGCCGCCGCCACCTCCTCCCCCACTCAGCCCTGGCCTGGCC       c.120
 A  P  G  A  S  A  P  P  P  P  P  P  P  P  L  S  P  G  L  A         p.40

          .         .         .         .         .         .       g.1874
 CCGGGGACCACCCCAGCCTCTCCCACGGCCAGCGGCCTGGCCCCCTTCGCCTCCCCGCGG       c.180
 P  G  T  T  P  A  S  P  T  A  S  G  L  A  P  F  A  S  P  R         p.60

          .         .         .         .         .         .       g.1934
 CACGGCCTAGCGCTGCCGGAGGGGGATGGCAGTCGGGATCCGCCCGACAGGCCCCGATCC       c.240
 H  G  L  A  L  P  E  G  D  G  S  R  D  P  P  D  R  P  R  S         p.80

          .         .         .         .         .         .       g.1994
 CCGGACCCGGTTGACGGTACCAGCTGTTGCAGTACCACCAGCACAATCTGTACCGTCGCC       c.300
 P  D  P  V  D  G  T  S  C  C  S  T  T  S  T  I  C  T  V  A         p.100

          .         .         .         .         .         .       g.2054
 GCCGCTCCCGTGGTCCCAGCGGTTTCTACTTCATCTGCCGCTGGGGTCGCTCCCAACCCA       c.360
 A  A  P  V  V  P  A  V  S  T  S  S  A  A  G  V  A  P  N  P         p.120

          .         .         .         .         .         .       g.2114
 GCCGGCAGTGGCAGTAACAATTCACCGTCGTCCTCTTCTTCCCCGACTTCTTCCTCATCT       c.420
 A  G  S  G  S  N  N  S  P  S  S  S  S  S  P  T  S  S  S  S         p.140

          .         .         .         .         .         .       g.2174
 TCCTCTCCATCCTCCCCTGGATCGAGCTTGGCGGAGAGCCCCGAGGCGGCCGGAGTTAGC       c.480
 S  S  P  S  S  P  G  S  S  L  A  E  S  P  E  A  A  G  V  S         p.160

          .         .         .         .         .         .       g.2234
 AGCACAGCACCACTGGGGCCTGGGGCAGCAGGACCTGGGACAGGGGTCCCAGCAGTGAGC       c.540
 S  T  A  P  L  G  P  G  A  A  G  P  G  T  G  V  P  A  V  S         p.180

          .         .         .         .         .         .       g.2294
 GGGGCCCTACGGGAACTGCTGGAGGCCTGTCGCAATGGGGACGTGTCCCGGGTAAAGAGG       c.600
 G  A  L  R  E  L  L  E  A  C  R  N  G  D  V  S  R  V  K  R         p.200

          .         .         .         .         .         .       g.2354
 CTGGTGGACGCGGCAAACGTAAATGCAAAGGACATGGCCGGCCGGAAGTCTTCTCCCCTG       c.660
 L  V  D  A  A  N  V  N  A  K  D  M  A  G  R  K  S  S  P  L         p.220

          .    | 02    .         .         .         .         .    g.25960
 CACTTCGCTGCAG | GTTTTGGAAGGAAGGATGTTGTAGAACACTTACTACAGATGGGTGCT    c.720
 H  F  A  A  G |   F  G  R  K  D  V  V  E  H  L  L  Q  M  G  A      p.240

          .         .         .         .         .         .       g.26020
 AATGTCCACGCTCGTGATGATGGAGGTCTCATCCCGCTTCATAATGCCTGTTCTTTTGGC       c.780
 N  V  H  A  R  D  D  G  G  L  I  P  L  H  N  A  C  S  F  G         p.260

          .         .         .         .         .         .       g.26080
 CATGCTGAGGTTGTGAGTCTGTTATTGTGCCAAGGAGCTGATCCAAATGCCAGGGATAAC       c.840
 H  A  E  V  V  S  L  L  L  C  Q  G  A  D  P  N  A  R  D  N         p.280

          .         .         .         .         .         | 03    g.61338
 TGGAACTATACACCTCTGCATGAAGCTGCTATTAAAGGGAAGATCGATGTGTGCATTG | TG    c.900
 W  N  Y  T  P  L  H  E  A  A  I  K  G  K  I  D  V  C  I  V |       p.300

          .         .         .         .         .         .       g.61398
 CTGCTGCAGCACGGAGCTGACCCAAACATTCGGAACACTGATGGGAAATCAGCCCTGGAC       c.960
 L  L  Q  H  G  A  D  P  N  I  R  N  T  D  G  K  S  A  L  D         p.320

          .         .         .     | 04   .         .         .    g.125731
 CTGGCAGATCCTTCAGCAAAAGCTGTCCTTACAG | GTGAATACAAGAAAGACGAACTCCTA    c.1020
 L  A  D  P  S  A  K  A  V  L  T  G |   E  Y  K  K  D  E  L  L      p.340

          .  | 05      .         .         .         .         .    g.126528
 GAAGCTGCTAG | GAGTGGTAATGAAGAAAAACTAATGGCTTTACTGACTCCTCTAAATGTG    c.1080
 E  A  A  R  |  S  G  N  E  E  K  L  M  A  L  L  T  P  L  N  V      p.360

          .         .        | 06.         .         .         .    g.150450
 AATTGCCATGCAAGTGATGGGCGAAAG | TCGACTCCTTTACATCTAGCAGCGGGCTACAAC    c.1140
 N  C  H  A  S  D  G  R  K   | S  T  P  L  H  L  A  A  G  Y  N      p.380

          .         .         .         .         .         .       g.150510
 AGAGTTCGAATAGTTCAGCTTCTTCTTCAGCATGGTGCTGATGTTCATGCAAAAGACAAA       c.1200
 R  V  R  I  V  Q  L  L  L  Q  H  G  A  D  V  H  A  K  D  K         p.400

    | 07     .         .         .         .         .         .    g.151999
 GG | TGGACTTGTGCCTCTTCATAATGCATGTTCATATGGACATTATGAAGTCACAGAACTG    c.1260
 G  |  G  L  V  P  L  H  N  A  C  S  Y  G  H  Y  E  V  T  E  L      p.420

           | 08        .         .         .         .         .    g.152616
 CTACTAAAG | CATGGAGCTTGTGTTAATGCCATGGATCTCTGGCAGTTTACTCCACTGCAC    c.1320
 L  L  K   | H  G  A  C  V  N  A  M  D  L  W  Q  F  T  P  L  H      p.440

          .         .         .         .         .         .       g.152676
 GAGGCTGCTTCCAAGAACCGTGTAGAAGTCTGCTCTTTGTTACTTAGCCATGGCGCTGAT       c.1380
 E  A  A  S  K  N  R  V  E  V  C  S  L  L  L  S  H  G  A  D         p.460

          .         .         .         .         .         .       g.152736
 CCTACATTAGTCAACTGCCATGGCAAAAGTGCTGTGGATATGGCTCCAACTCCGGAGCTT       c.1440
 P  T  L  V  N  C  H  G  K  S  A  V  D  M  A  P  T  P  E  L         p.480

          .       | 09 .         .         .         .         .    g.154169
 AGGGAGAGATTGACTT | ATGAATTTAAAGGTCATTCTTTACTACAAGCAGCCAGAGAAGCA    c.1500
 R  E  R  L  T  Y |   E  F  K  G  H  S  L  L  Q  A  A  R  E  A      p.500

          .         .         .         .         .         .       g.154229
 GACTTAGCTAAAGTTAAAAAAACACTCGCTCTGGAAATCATTAATTTCAAACAACCGCAG       c.1560
 D  L  A  K  V  K  K  T  L  A  L  E  I  I  N  F  K  Q  P  Q         p.520

          .         | 10         .         .         .         .    g.155751
 TCTCATGAAACAGCACTG | CACTGTGCTGTGGCCTCTCTGCATCCCAAACGTAAACAAGTG    c.1620
 S  H  E  T  A  L   | H  C  A  V  A  S  L  H  P  K  R  K  Q  V      p.540

          .         .         .         .         . | 11       .    g.155906
 ACAGAATTGTTACTTAGAAAAGGAGCAAATGTTAATGAAAAAAATAAAGA | TTTCATGACT    c.1680
 T  E  L  L  L  R  K  G  A  N  V  N  E  K  N  K  D  |  F  M  T      p.560

          .         .         .         .         .         .       g.155966
 CCCCTGCATGTTGCAGCCGAAAGAGCCCATAATGATGTCATGGAAGTTCTGCATAAGCAT       c.1740
 P  L  H  V  A  A  E  R  A  H  N  D  V  M  E  V  L  H  K  H         p.580

           | 12        .         .         .         .         .    g.166179
 GGCGCCAAG | ATGAATGCACTGGACACCCTTGGTCAGACTGCTTTGCATAGAGCCGCCCTA    c.1800
 G  A  K   | M  N  A  L  D  T  L  G  Q  T  A  L  H  R  A  A  L      p.600

          .         .         .         .         .         .       g.166239
 GCAGGTCACCTGCAGACCTGCCGCCTCCTGCTGAGTTACGGCTCTGACCCCTCCATCATC       c.1860
 A  G  H  L  Q  T  C  R  L  L  L  S  Y  G  S  D  P  S  I  I         p.620

          .         .         .         .         .         .       g.166299
 TCCTTACAAGGCTTCACAGCAGCACAGATGGGCAATGAAGCAGTGCAGCAGATTCTGAGT       c.1920
 S  L  Q  G  F  T  A  A  Q  M  G  N  E  A  V  Q  Q  I  L  S         p.640

   | 13      .         .         .         .         .         .    g.172454
 G | AGAGTACACCTATACGTACTTCTGATGTTGATTATCGACTCTTAGAGGCATCTAAAGCT    c.1980
 E |   S  T  P  I  R  T  S  D  V  D  Y  R  L  L  E  A  S  K  A      p.660

          .         .  | 14      .         .         .         .    g.176683
 GGAGACTTGGAAACTGTGAAG | CAACTTTGCAGCTCTCAAAATGTGAATTGTAGAGACTTA    c.2040
 G  D  L  E  T  V  K   | Q  L  C  S  S  Q  N  V  N  C  R  D  L      p.680

          .         .         .         .         .         .       g.176743
 GAGGGCCGGCATTCCACGCCCTTACACTTCGCAGCAGGCTACAACCGCGTGTCTGTTGTA       c.2100
 E  G  R  H  S  T  P  L  H  F  A  A  G  Y  N  R  V  S  V  V         p.700

          .         .         .         .        | 15.         .    g.179046
 GAGTACCTGCTACACCACGGTGCCGATGTCCATGCCAAAGACAAGGG | TGGCTTGGTGCCC    c.2160
 E  Y  L  L  H  H  G  A  D  V  H  A  K  D  K  G  |  G  L  V  P      p.720

          .         .         .         .         .         .       g.179106
 CTTCATAATGCCTGTTCATATGGACACTATGAGGTGGCTGAGCTTTTAGTAAGGCATGGG       c.2220
 L  H  N  A  C  S  Y  G  H  Y  E  V  A  E  L  L  V  R  H  G         p.740

          .         .         .         .         .         .       g.179166
 GCTTCTGTCAATGTGGCGGACTTATGGAAATTTACCCCTCTCCATGAAGCAGCAGCTAAA       c.2280
 A  S  V  N  V  A  D  L  W  K  F  T  P  L  H  E  A  A  A  K         p.760

          .         .         .    | 16    .         .         .    g.180646
 GGAAAGTATGAAATCTGCAAGCTCCTTTTAAAA | CATGGAGCAGATCCAACTAAAAAGAAC    c.2340
 G  K  Y  E  I  C  K  L  L  L  K   | H  G  A  D  P  T  K  K  N      p.780

          .         .         .         .         .         .       g.180706
 AGAGATGGAAATACACCTTTGGATTTGGTAAAGGAAGGAGACACAGATATTCAGGACTTA       c.2400
 R  D  G  N  T  P  L  D  L  V  K  E  G  D  T  D  I  Q  D  L         p.800

          .         .         .         .         .         .       g.180766
 CTGAGAGGGGATGCTGCTTTGTTGGATGCTGCCAAGAAGGGCTGCCTGGCAAGAGTGCAG       c.2460
 L  R  G  D  A  A  L  L  D  A  A  K  K  G  C  L  A  R  V  Q         p.820

          .         .         .         .         .         .       g.180826
 AAGCTCTGTACCCCAGAGAATATCAACTGCAGAGACACCCAGGGCAGAAATTCAACCCCT       c.2520
 K  L  C  T  P  E  N  I  N  C  R  D  T  Q  G  R  N  S  T  P         p.840

          .    | 17    .         .         .         .         .    g.181178
 CTGCACCTGGCAG | CAGGCTATAATAACCTGGAAGTAGCTGAATATCTTCTAGAGCATGGA    c.2580
 L  H  L  A  A |   G  Y  N  N  L  E  V  A  E  Y  L  L  E  H  G      p.860

          .         .         .         .         .         .       g.181238
 GCTGATGTTAATGCCCAGGACAAGGGTGGTTTAATTCCTCTTCATAATGCGGCATCTTAT       c.2640
 A  D  V  N  A  Q  D  K  G  G  L  I  P  L  H  N  A  A  S  Y         p.880

     | 18    .         .         .         .         .         .    g.193835
 GGG | CATGTTGACATAGCGGCTTTATTGATAAAATACAACACGTGTGTAAATGCAACAGAT    c.2700
 G   | H  V  D  I  A  A  L  L  I  K  Y  N  T  C  V  N  A  T  D      p.900

          .         .         .         .         .         .       g.193895
 AAGTGGGCGTTTACTCCCCTCCATGAAGCAGCCCAGAAAGGAAGGACGCAGCTGTGCGCC       c.2760
 K  W  A  F  T  P  L  H  E  A  A  Q  K  G  R  T  Q  L  C  A         p.920

          .         .         .         .         .         .       g.193955
 CTCCTCCTAGCGCATGGTGCAGACCCCACCATGAAGAACCAGGAAGGCCAGACGCCTCTG       c.2820
 L  L  L  A  H  G  A  D  P  T  M  K  N  Q  E  G  Q  T  P  L         p.940

          .   | 19     .         .         .         .         .    g.197411
 GATCTGGCAACA | GCTGACGATATCAGAGCTTTGCTGATAGATGCCATGCCCCCAGAGGCC    c.2880
 D  L  A  T   | A  D  D  I  R  A  L  L  I  D  A  M  P  P  E  A      p.960

          .         .         .         .         .         .       g.197471
 TTACCTACCTGTTTTAAACCTCAGGCTACTGTAGTGAGTGCCTCTCTGATCTCACCAGCA       c.2940
 L  P  T  C  F  K  P  Q  A  T  V  V  S  A  S  L  I  S  P  A         p.980

          .         .         .         .         .         .       g.197531
 TCCACCCCCTCCTGCCTCTCGGCTGCCAGCAGCATAGACAACCTCACTGGCCCTTTAGCA       c.3000
 S  T  P  S  C  L  S  A  A  S  S  I  D  N  L  T  G  P  L  A         p.1000

          .         .         .         .         .         .       g.197591
 GAGTTGGCCGTAGGAGGAGCCTCCAATGCAGGGGATGGCGCCGCGGGAACAGAAAGGAAG       c.3060
 E  L  A  V  G  G  A  S  N  A  G  D  G  A  A  G  T  E  R  K         p.1020

          . | 20       .         .         .         .         .    g.198348
 GAAGGAGAAG | TTGCTGGTCTTGACATGAATATCAGCCAATTTCTAAAAAGCCTTGGCCTT    c.3120
 E  G  E  V |   A  G  L  D  M  N  I  S  Q  F  L  K  S  L  G  L      p.1040

          .         .         .    | 21    .         .         .    g.207297
 GAACACCTTCGGGATATCTTTGAAACAGAACAG | ATTACACTAGATGTGTTGGCTGATATG    c.3180
 E  H  L  R  D  I  F  E  T  E  Q   | I  T  L  D  V  L  A  D  M      p.1060

          .         .         .         .         .         .       g.207357
 GGTCATGAAGAGTTGAAAGAAATAGGCATCAATGCATATGGGCACCGCCACAAATTAATC       c.3240
 G  H  E  E  L  K  E  I  G  I  N  A  Y  G  H  R  H  K  L  I         p.1080

          .         .         .     | 22   .         .         .    g.208927
 AAAGGAGTAGAAAGACTCTTAGGTGGACAACAAG | GCACCAATCCTTATTTGACTTTTCAC    c.3300
 K  G  V  E  R  L  L  G  G  Q  Q  G |   T  N  P  Y  L  T  F  H      p.1100

          .         .         .         .         .         .       g.208987
 TGTGTTAATCAGGGAACGATTTTGCTGGATCTTGCTCCAGAAGATAAAGAATATCAGTCA       c.3360
 C  V  N  Q  G  T  I  L  L  D  L  A  P  E  D  K  E  Y  Q  S         p.1120

          .   | 23     .         .         .         .         .    g.210518
 GTGGAAGAAGAG | ATGCAAAGTACTATTCGAGAACACAGAGATGGTGGTAATGCTGGCGGC    c.3420
 V  E  E  E   | M  Q  S  T  I  R  E  H  R  D  G  G  N  A  G  G      p.1140

          .         .        | 24.         .         .         .    g.211479
 ATCTTCAACAGATACAATGTCATTCGA | ATTCAAAAAGTTGTCAACAAGAAGTTGAGGGAG    c.3480
 I  F  N  R  Y  N  V  I  R   | I  Q  K  V  V  N  K  K  L  R  E      p.1160

          .         .         .         .         .         .       g.211539
 CGGTTCTGCCACCGACAGAAGGAAGTGTCTGAGGAGAATCACAACCATCACAATGAGCGC       c.3540
 R  F  C  H  R  Q  K  E  V  S  E  E  N  H  N  H  H  N  E  R         p.1180

          .    | 25    .         .         .         .         .    g.212040
 ATGTTGTTTCATG | GTTCTCCTTTCATTAATGCCATTATTCATAAAGGGTTTGATGAGCGA    c.3600
 M  L  F  H  G |   S  P  F  I  N  A  I  I  H  K  G  F  D  E  R      p.1200

          .         .         .         .         .         .       g.212100
 CATGCATACATAGGAGGAATGTTTGGGGCCGGGATTTATTTTGCTGAAAACTCCTCAAAA       c.3660
 H  A  Y  I  G  G  M  F  G  A  G  I  Y  F  A  E  N  S  S  K         p.1220

          .         .         .         .         .         .       g.212160
 AGCAACCAATATGTTTATGGAATTGGAGGAGGAACAGGCTGCCCTACACACAAGGACAGG       c.3720
 S  N  Q  Y  V  Y  G  I  G  G  G  T  G  C  P  T  H  K  D  R         p.1240

          .         . | 26       .         .         .         .    g.215900
 TCATGCTATATATGTCACAG | ACAAATGCTCTTCTGTAGAGTGACCCTTGGGAAATCCTTT    c.3780
 S  C  Y  I  C  H  R  |  Q  M  L  F  C  R  V  T  L  G  K  S  F      p.1260

          .         .         .         .         .         .       g.215960
 CTGCAGTTTAGCACCATGAAAATGGCCCACGCGCCTCCAGGGCACCACTCAGTCATTGGT       c.3840
 L  Q  F  S  T  M  K  M  A  H  A  P  P  G  H  H  S  V  I  G         p.1280

          .         .         .         .         .        | 27.    g.222407
 AGACCGAGCGTCAATGGGCTGGCATATGCTGAATATGTCATCTACAGAGGAGAACAG | GCA    c.3900
 R  P  S  V  N  G  L  A  Y  A  E  Y  V  I  Y  R  G  E  Q   | A      p.1300

          .         .         .         .         .         .       g.222467
 TACCCAGAGTATCTTATCACTTACCAGATCATGAAGCCAGAAGCCCCTTCCCAGACCGCA       c.3960
 Y  P  E  Y  L  I  T  Y  Q  I  M  K  P  E  A  P  S  Q  T  A         p.1320

          .         .                                               g.222491
 ACAGCCGCAGAGCAGAAGACCTAG                                           c.3984
 T  A  A  E  Q  K  T  X                                             p.1327

          .         .         .         .         .         .       g.222551
 tgaatgcctgctggtgaaggccagatcagatttcaacctgggactggattacagaggatt       c.*60

          .         .         .         .         .         .       g.222611
 gtttctaataacaacatcaatattctagaagtccctgacagcctagaaataagctgtttg       c.*120

          .         .         .         .         .         .       g.222671
 tcttctataaagcattgctatagtgatgaatagtatgagtaactgatacatactcaactg       c.*180

          .         .         .         .         .         .       g.222731
 ctactgttccctttgaggaaatgtttacaggggcggccttttaacatatctcaggctcat       c.*240

          .         .         .         .         .         .       g.222791
 tttcattgcaattatccatttctaaaacaagattgcttcgatctagacttggaaatggaa       c.*300

          .         .         .         .         .         .       g.222851
 aataagaaaaccaatgctttttcaaatgttcacaattcacacactacatttgttttgtta       c.*360

          .         .         .         .         .         .       g.222911
 tgcatgacgtgtctataacaaatatacacatacgacaggcaacaagcttgtttttgattt       c.*420

          .         .         .         .         .         .       g.222971
 gccagacatgcatcattggctattgtttgtttgttttttgtttttttgtgttttttgggt       c.*480

          .         .         .         .         .         .       g.223031
 tactttgaaaatgagccagagccttcttgaggatattttgcacaaagtcacgctgacaaa       c.*540

          .         .         .         .         .         .       g.223091
 atcattagcagtgcaacccaagcttctggctgagcaagattcagtttccactttttaaaa       c.*600

          .         .         .         .         .         .       g.223151
 tttttttattttgctctgtagctgcacttctcgttatcataaattgagatgaaaaggaaa       c.*660

          .         .         .         .         .         .       g.223211
 aaacatcaagttttagtacctttttatgaattggcctatcttacaagagaagggcacaaa       c.*720

          .         .         .         .         .         .       g.223271
 caccaacctgacttaggaacgcctaaattcagagaagtcaaagccggtgaaggccacttg       c.*780

          .         .         .         .         .         .       g.223331
 ctctttccaacacaagcctgccacagaggtcttcgggacagtactggagatgcaggttga       c.*840

          .         .         .         .         .         .       g.223391
 cacgggcttgagttccaaggtgaaaaaactggggaggctgtgaaggaagagctgcattaa       c.*900

          .         .         .         .         .         .       g.223451
 ggagggtgaggagcgtgtggttctgtatcatggcagccccaatggatccaggggatgcct       c.*960

          .         .         .         .         .         .       g.223511
 ccaaaaaatacatgcttcccttcccttaatctgtactgttgggattgttacccctccaaa       c.*1020

          .         .         .         .         .         .       g.223571
 ttagctgccttatttcaaaagtcagtgaaattactgcacttgatgagggtcacaaaaata       c.*1080

          .         .         .         .         .         .       g.223631
 ccacttgattgtttctttagttgagaatgctgggattcagactcgaatagtggatagata       c.*1140

          .         .         .         .         .         .       g.223691
 cacacaaatgcaaggacttttttgtttactccagatttggggtttattttgagtggcatg       c.*1200

          .         .         .         .         .         .       g.223751
 cttcaaatagttcataaagatccttgcattaaatttctgaaccatttcttcaaacttctt       c.*1260

          .         .         .         .         .         .       g.223811
 agtgtgtttagacaaggagaacaaaaattgaaaccaaagccctttctgttattttttcaa       c.*1320

          .         .         .         .         .         .       g.223871
 tgaaggtgagaaagaaataccatacaattttctttgtgaaattactgtttattttcatca       c.*1380

          .         .         .         .         .         .       g.223931
 acatttaccaagtgccattgacatttataaaaaaaaatgatcctttatagttcttacact       c.*1440

          .         .         .         .         .         .       g.223991
 tgcccttttcaccttaactgaatatgaattgagtgcactaacttatttacttgatatact       c.*1500

          .         .         .         .         .         .       g.224051
 gtgcatctactctgctttgaagcgaaagaaatataaacacgaggaggaataggaaagaca       c.*1560

          .         .         .         .         .         .       g.224111
 gtgtgacacaaacttgccattgcaattcaaagccctgaaaacgatgggtttaatgcaagg       c.*1620

          .         .         .         .         .         .       g.224171
 tgattaagctgtgacctcctttaatctcctgaagcaaaataaaatggttacatgcaaaac       c.*1680

          .         .         .         .         .         .       g.224231
 ttctagaaatagactcttaaaatatatacattttgctttgattttggcttcaacccagtg       c.*1740

          .         .         .         .         .         .       g.224291
 ctggaactaggcatccagactagtttgaatgtttgtagctgaatttttatgggtcctcaa       c.*1800

          .         .         .         .         .         .       g.224351
 aattaaatcgagaattagcctcagttgttgcttcttttgaagtttcagtgacccaagctg       c.*1860

          .         .         .         .         .         .       g.224411
 ggtgtttgtgtcttggctacttgtttaatagcactagaattccaggtgaagctttgagag       c.*1920

          .         .         .         .         .         .       g.224471
 ttgatattcattaagagggctttttttccccttctttccttctcttttgctgtaacaaag       c.*1980

          .         .         .         .         .         .       g.224531
 ggttgaagaaattgccatctgtgtagttttcagtagctgtcaagtgtgtcttacttacct       c.*2040

          .         .         .         .         .         .       g.224591
 tcccccagacgtagtttaaaatggtaaacacagctgtgatttttagttaagtaaaagagt       c.*2100

          .         .         .         .         .         .       g.224651
 taatatgatatagatatggaaagctttatggcttcattaaaaagataaaccactacctaa       c.*2160

          .         .         .         .         .         .       g.224711
 ctgtggttgtatgttgtttccatcatactaactagatgaatggatgcgccagttttcatc       c.*2220

          .         .         .         .         .         .       g.224771
 ttggtccttacacttgagaagttaaactgtggttcagtatttaaactgccagtgttatac       c.*2280

          .         .         .         .         .         .       g.224831
 gtctcatgctctgtgtgccaggtgaaggtactgtgtaaggaagacatttgcggtgcttct       c.*2340

          .         .         .         .         .         .       g.224891
 tgtcctataatgattcaagtatatagtagttcttgaaagagtgtgcatatattactcatc       c.*2400

          .         .         .         .         .         .       g.224951
 tgcttaagagagtgggttaatggatatatcagaggagccaaatacatttttttcagaact       c.*2460

          .         .         .         .         .         .       g.225011
 tgaaaaccaaaggtcatcatgagtgcactcaaaagttaggacaagtttattacatttggg       c.*2520

          .         .         .         .         .         .       g.225071
 attttcatctgtagccgtatgaagaaccctttccaatataaaagcatggcattaaattag       c.*2580

          .         .         .         .         .         .       g.225131
 gctgaagtcttttattttttgtatatgtactatatagaaatactagcaagttaggatcat       c.*2640

          .         .         .         .         .         .       g.225191
 ccaatatggcctaccccgaaatggcccctctgtttccctaaccacatggaagaaagaatc       c.*2700

          .         .         .         .         .         .       g.225251
 tgaacgtctccaccggctctacccgagttccaaaactaaagggcttctccagacctgatg       c.*2760

          .         .         .         .         .         .       g.225311
 gttccagtttacctgctgttggcctgctggatacttgactcaggcataaattaagtgccc       c.*2820

          .         .         .         .         .         .       g.225371
 tggtcccgaactttctccctgtatttgacctccttccctctttcctaaattactagtctg       c.*2880

          .         .         .         .         .         .       g.225431
 gaattaaaattagctccagcaatgacctttgactccattcattttctcctcatcttgggt       c.*2940

          .         .         .         .         .         .       g.225491
 cttaaaaaaggagaccagatacctcctagcttttgtatcacaaccaggaatgggtattag       c.*3000

          .         .         .         .         .         .       g.225551
 gcctcatgcgctttgctcagaacactgccgctttgttaacaaatgacagcatggaaccca       c.*3060

          .         .         .         .         .         .       g.225611
 gagttttgattcgatgcaaaataacagcagtgcaaccaggattcttgttttccttttcct       c.*3120

          .         .         .         .         .         .       g.225671
 tcttggagtttggaatttctagcttttcaagcagcataagtagaatcaacattaggatgt       c.*3180

          .         .         .         .         .         .       g.225731
 tttcatgaaatagcatccttatacttctttgagcttgatgttagtggctagactgatttc       c.*3240

          .         .         .         .         .         .       g.225791
 cctttgctctcaaaatacaaagtgcattgaagtatacagagaaatgcctgaatatggcaa       c.*3300

          .         .         .         .         .         .       g.225851
 gcaaataatgtagattaacattctattattgtatccgttttacaaaaaataaaattttga       c.*3360

          .         .         .         .         .         .       g.225911
 tatatgccggagaacggcattagaatgcaataagttgtctaggtttttctgtttcagtgt       c.*3420

          .         .         .         .         .         .       g.225971
 ctctcccaatggcacgaagggttattgggcattgtccccacccccgcctttttaacatgt       c.*3480

          .         .         .         .         .         .       g.226031
 gcactatctggattcctgtaaatggccttgcaaacagaagtggtgtgtattttcaagcac       c.*3540

          .         .         .         .         .         .       g.226091
 ctttcccccattgtatccgaatccctcttgtgtgatatctgtgacaaatagccttcttct       c.*3600

          .         .         .         .         .         .       g.226151
 tgtgttttctgttggactaattgtctcacgtaaagctatagaccttactaatttggcagg       c.*3660

          .         .         .         .         .         .       g.226211
 tattcaaaactgccattaagataggatttcatgtcagatacgtatttaaagagtaaagtc       c.*3720

          .         .         .         .         .         .       g.226271
 aaatttgtttaatgtcagatcagtgacagaagtgaaaagaaagtaattgtgaaagtgatg       c.*3780

          .         .         .         .         .         .       g.226331
 tttgagctattgtacacatctagcatatggaaagcaaatgcactcgaaaactactattct       c.*3840

          .         .         .         .         .         .       g.226391
 agaacatgaggcttcttcagcaacttgtgcactctgccattaataaattaaatttttccc       c.*3900

          .         .         .         .         .         .       g.226451
 ctctagaaagccttaactatggcggaaactttttaaccttttatattttaataaataaaa       c.*3960

          .         .         .         .         .         .       g.226511
 cattgtagtcccatttcttagtgtttgaaaggtgtgtcagtgagtcggccatgtctccat       c.*4020

          .         .         .         .         .         .       g.226571
 gtgtttcagacctgttcatcttattttatgatggtatatttcataagtaatattccctta       c.*4080

          .         .         .         .         .         .       g.226631
 catgcaatggagctgattaaaattaatccatttcaatttctccatattggaacttcctca       c.*4140

          .         .         .         .         .         .       g.226691
 gctaccagatttctggtttggagaagtgctggaaagatttcaaagcctattcagttgtgt       c.*4200

          .         .         .         .         .         .       g.226751
 atgtggggatacgacagcaactgtgataccttgtagaatatgagtgatatgcaagctgtg       c.*4260

          .         .         .         .         .         .       g.226811
 ttttttaattgttttaaaatgtaaattatggttatgctaaagtgaaaacctagaggaagc       c.*4320

          .         .         .         .         .         .       g.226871
 taatgattttatatactttgcacgaccaaatatggtcgtagtatgacgagttttatacat       c.*4380

          .         .         .         .         .         .       g.226931
 tgccagagagttctgcctcctctgaaataacattcgcactgtagattgcatttcggcttt       c.*4440

          .         .         .         .         .         .       g.226991
 tcctcctttcacattcttttttgctttacacttcacgtcttcgcacctgccctacctccc       c.*4500

          .         .         .         .         .         .       g.227051
 atcctttcaaagaggtttctttcacgttccagaattcagattgttctgtgatttctttta       c.*4560

          .         .         .         .         .         .       g.227111
 catcagtctacccatttctgcaggcagccctgaaagcccttgtgttgattcagagtgttt       c.*4620

          .         .         .         .         .         .       g.227171
 gcagagaaatgcagttgaaccctggtagtggggtgtccctcacacacccgcgcacccctc       c.*4680

          .         .         .         .         .         .       g.227231
 ccaaagttcaggatgaaaggctagaaaacccattcaaagttaggaaagaacacagatctt       c.*4740

          .         .         .         .         .         .       g.227291
 tgaggccgatagcctagacctagaagatgaccttgagtatgtaaacattgtctccgtgac       c.*4800

          .         .         .         .         .         .       g.227351
 acaaaacactgaaactcttcatgtgcatataacacctgcttctgctcccattgtttcaag       c.*4860

          .         .         .         .         .         .       g.227411
 ctcatcttatctttgtagtagtaatgtttgtctttgatacctacaaactaaaaaggtact       c.*4920

          .         .         .         .         .         .       g.227471
 tttatcaaggtttctcaaaacatttacaaaaccagctttgagaaaatgttatgttgcctg       c.*4980

          .         .         .         .         .         .       g.227531
 gcaacagcactcggagtagtaattgtgttttctcattgtgatgttggtctgtgtgagcaa       c.*5040

          .         .         .         .         .         .       g.227591
 ccagtgtagtgactctttggttcattattcgtgttgtttttatttttagtctctgtgtga       c.*5100

          .         .         .         .         .         .       g.227651
 cccaacagtggcaggggttacaaccccctctcctttcttttttgtatttatctatttgta       c.*5160

          .         .         .         .         .         .       g.227711
 ggattgtcagatcaagtacaagatgcccagttaagtttgaatttcagagaaacaatttca       c.*5220

          .         .         .         .         .         .       g.227771
 cgttaagaatgtttcatgcaatatttggcatatatttacagtaaaagcattcattatttg       c.*5280

          .         .         .         .         .         .       g.227831
 tctgaaattcaaatttaactgagcatgctggtttttctcattgtttggtttttctaaatc       c.*5340

          .         .         .         .         .         .       g.227891
 tggcaatcctacagctgtggtcatgggaaatcacctacagcatgttaaagtcctctagtc       c.*5400

          .         .         .         .         .         .       g.227951
 atcatctcgtcacctgaaatggaagtcctttttccctcaccctccacttctttccaaagg       c.*5460

          .         .         .         .         .         .       g.228011
 agggcatcaaggaacttaacctgcctgcctggtgggtttctatttaagacatctttgtga       c.*5520

          .         .         .         .         .         .       g.228071
 ttatatttaacctgcaattgtgctttggcttaatgtctagctcactgtacttgtaaatga       c.*5580

          .         .         .                                     g.228101
 ttaatattcaataaaaccatttttaaagta                                     c.*5610

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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