vacuolar protein sorting 13 homolog B (yeast) (VPS13B) - coding DNA reference sequence

(used for mutation description)

(last modified May 1, 2014)


This file was created to facilitate the description of sequence variants in the VPS13B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering VPS13B transcript NM_017890.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.1246
          ggcgcggtacaggagcagcactgccggcgggggcgggtgccagggacttgg       c.-61

 .         .         .         . | 02       .         .             g.1718
 aggtggaggggacgcggcggtactctggcgt | cttccgacttcgactccttaccttaaaag    c.-1

          .         .         .         .         .         .       g.1778
 ATGCTGGAGTCATATGTAACTCCAATTTTAATGAGCTATGTGAATCGCTACATCAAGAAC       c.60
 M  L  E  S  Y  V  T  P  I  L  M  S  Y  V  N  R  Y  I  K  N         p.20

          .         .         .         .         .         .       g.1838
 TTAAAGCCGTCGGATCTACAGCTTTCACTATGGGGTGGAGACGTGGTACTCAGCAAGCTC       c.120
 L  K  P  S  D  L  Q  L  S  L  W  G  G  D  V  V  L  S  K  L         p.40

          .         .        | 03.         .         .         .    g.26385
 GAGTTAAAGTTGGATGTGCTGGAACAG | GAACTGAAATTACCATTCACTTTTTTAAGTGGA    c.180
 E  L  K  L  D  V  L  E  Q   | E  L  K  L  P  F  T  F  L  S  G      p.60

          .         .         .         .         .         .       g.26445
 CATATTCATGAATTGAGGATTCATGTACCATGGACAAAACTGGGTTCAGAACCAGTGGTA       c.240
 H  I  H  E  L  R  I  H  V  P  W  T  K  L  G  S  E  P  V  V         p.80

          .         .         .         .         .  | 04      .    g.84250
 ATTACCATCAATACTATGGAATGCATTTTGAAACTTAAGGATGGGATACAG | GATGACCAT    c.300
 I  T  I  N  T  M  E  C  I  L  K  L  K  D  G  I  Q   | D  D  H      p.100

          .         .         .         .         .         .       g.84310
 GAAAGCTGTGGTTCTAATTCTACCAACCGTAGTACTGCTGAGAGCACAAAATCATCAATC       c.360
 E  S  C  G  S  N  S  T  N  R  S  T  A  E  S  T  K  S  S  I         p.120

          .         .         .         .         .   | 05     .    g.90890
 AAACCGCGGAGAATGCAGCAGGCTGCTCCTACAGATCCTGACTTACCACCAG | GTTATGTG    c.420
 K  P  R  R  M  Q  Q  A  A  P  T  D  P  D  L  P  P  G |   Y  V      p.140

          .         .         .         .         .         .       g.90950
 CAGAGTCTGATTAGACGAGTTGTAAATAATGTAAACATTGTGATAAATAATCTCATACTA       c.480
 Q  S  L  I  R  R  V  V  N  N  V  N  I  V  I  N  N  L  I  L         p.160

          .         .         .         .         .         .       g.91010
 AAATATGTTGAAGATGATATCGTCCTTTCCGTCAATATCACTTCTGCAGAATGTTATACA       c.540
 K  Y  V  E  D  D  I  V  L  S  V  N  I  T  S  A  E  C  Y  T         p.180

          .         .         .         . | 06       .         .    g.99047
 GTAGGTGAATTATGGGATCGTGCATTCATGGATATTTCTG | CAACTGATTTGGTGCTGAGA    c.600
 V  G  E  L  W  D  R  A  F  M  D  I  S  A |   T  D  L  V  L  R      p.200

          .         .         .         .         .         .       g.99107
 AAGGTTATCAATTTTTCTGACTGTACAGTTTGTCTTGATAAACGGAATGCCAGTGGTAAA       c.660
 K  V  I  N  F  S  D  C  T  V  C  L  D  K  R  N  A  S  G  K         p.220

          .         .         .         .         .         .       g.99167
 ATAGAATTTTACCAGGATCCTTTATTATACAAATGTTCCTTCAGAACTCGTCTTCATTTT       c.720
 I  E  F  Y  Q  D  P  L  L  Y  K  C  S  F  R  T  R  L  H  F         p.240

          .         .         .         .   | 07     .         .    g.103647
 ACATATGAAAACCTAAATTCCAAGATGCCATCTGTTATTAAA | ATTCATACTTTAGTGGAA    c.780
 T  Y  E  N  L  N  S  K  M  P  S  V  I  K   | I  H  T  L  V  E      p.260

          .         .         .         .         .         .       g.103707
 AGTTTGAAACTTTCTATCACAGATCAACAACTGCCTATGTTTATTCGTATAATGCAACTT       c.840
 S  L  K  L  S  I  T  D  Q  Q  L  P  M  F  I  R  I  M  Q  L         p.280

          .         .         .         .         .         .       g.103767
 GGAATTGCTCTTTACTATGGAGAAATAGGCAATTTTAAAGAAGGCGAAATAGAGGACCTT       c.900
 G  I  A  L  Y  Y  G  E  I  G  N  F  K  E  G  E  I  E  D  L         p.300

          .         .         .        | 08.         .         .    g.109129
 ACTTGTCATAATAAAGATATGCTAGGAAACATTACAG | GTTCTGAAGATGAAACAAGAATA    c.960
 T  C  H  N  K  D  M  L  G  N  I  T  G |   S  E  D  E  T  R  I      p.320

          .         .         .         .         .         .       g.109189
 GATATGCAATATCCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAG       c.1020
 D  M  Q  Y  P  A  Q  H  K  G  Q  E  L  Y  S  Q  Q  D  E  E         p.340

          .         .         .         .         .         .       g.109249
 CAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTGCCTGCAATTGTGAGTTATGAC       c.1080
 Q  P  Q  G  W  V  S  W  A  W  S  F  V  P  A  I  V  S  Y  D         p.360

          .         .         .         .         .         .       g.109309
 GATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCA       c.1140
 D  G  E  E  D  F  V  G  N  D  P  A  S  T  M  H  Q  Q  K  A         p.380

          .         .         .         .         .         .       g.109369
 CAGACTTTGAAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACT       c.1200
 Q  T  L  K  D  P  I  V  S  I  G  F  Y  C  T  K  A  T  V  T         p.400

        | 09 .         .         .         .         .         .    g.122615
 TTCAAA | CTCACAGAAATGCAAGTTGAGAGTAGTTATTACAGTCCACAGAAAGTAAAATCT    c.1260
 F  K   | L  T  E  M  Q  V  E  S  S  Y  Y  S  P  Q  K  V  K  S      p.420

          .         .         .         .   | 10     .         .    g.122962
 AAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAG | GCCCTTATGATGGGAGAA    c.1320
 K  E  V  L  C  W  E  Q  E  G  T  T  V  E   | A  L  M  M  G  E      p.440

          .         .         .         .         .         .       g.123022
 CCTTTCTTTGATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAAAGGAATT       c.1380
 P  F  F  D  C  Q  I  G  F  V  G  C  R  A  M  C  L  K  G  I         p.460

          .         .         .         .      | 11  .         .    g.123540
 ATGGGTGTTAAAGATTTTGAAGAGAATATGAATAGAAGTGAAACT | GAAGCCTGTTTCTTC    c.1440
 M  G  V  K  D  F  E  E  N  M  N  R  S  E  T   | E  A  C  F  F      p.480

          .         .         .         .         .         .       g.123600
 ATTTGTGGTGACAATTTGAGTACGAAAGGTTTCACATACCTTACAAATTCATTGTTTGAT       c.1500
 I  C  G  D  N  L  S  T  K  G  F  T  Y  L  T  N  S  L  F  D         p.500

          .         .         .         .         .         .       g.123660
 TACCGAAGCCCAGAAAATAATGGTACTCGCGCAGAATTTATCTTGGATTCAACTCATCAT       c.1560
 Y  R  S  P  E  N  N  G  T  R  A  E  F  I  L  D  S  T  H  H         p.520

     | 12    .         .         .         .         .         .    g.124651
 AAG | GAGACATACACTGAGATAGCTGGAATGCAACGGTTTGGGGCTTTTTATATGGATTAC    c.1620
 K   | E  T  Y  T  E  I  A  G  M  Q  R  F  G  A  F  Y  M  D  Y      p.540

          .         .         .  | 13      .         .         .    g.130932
 CTGTATACAATGGAGAACACTAGTGGCAAAG | GTTCCACAAATCAACAAGACTTTTCTTCA    c.1680
 L  Y  T  M  E  N  T  S  G  K  G |   S  T  N  Q  Q  D  F  S  S      p.560

          .         .         .         .         .         .       g.130992
 GGGAAAAGTGAAGATTTGGGAACAGTTCAGGAGAAGTCCACCAAAAGCCTTGTTATAGGT       c.1740
 G  K  S  E  D  L  G  T  V  Q  E  K  S  T  K  S  L  V  I  G         p.580

          .         .         .         .         .         .       g.131052
 CCTCTTGATTTTCGTTTGGATAGCAGTGCGGTGCATAGGATTTTGAAAATGATTGTGTGT       c.1800
 P  L  D  F  R  L  D  S  S  A  V  H  R  I  L  K  M  I  V  C         p.600

          .         .         .         .    | 14    .         .    g.135787
 GCCTTGGAACATGAATATGAACCATATAGCAGGCTAAAATCAG | ATATTAAGGATGAAAAT    c.1860
 A  L  E  H  E  Y  E  P  Y  S  R  L  K  S  D |   I  K  D  E  N      p.620

          .         .         .         .         .         .       g.135847
 GAAACAATACTGAATCCTGAAGAGGTGGCTCTTCTGGAGGAATATATTCCTACTCGACAT       c.1920
 E  T  I  L  N  P  E  E  V  A  L  L  E  E  Y  I  P  T  R  H         p.640

          .         .         .         .         .         .       g.135907
 ACAAGTGTTACTCTCCTCAAATGTACCTGCACAATTTCCATGGCTGAATTCAACTTGCTG       c.1980
 T  S  V  T  L  L  K  C  T  C  T  I  S  M  A  E  F  N  L  L         p.660

          .         .         .    | 15    .         .         .    g.144505
 GACCATTTACTACCTGTCATTATGGGAGAAAAG | AACTCAAGTAACTTCATGAATACTACA    c.2040
 D  H  L  L  P  V  I  M  G  E  K   | N  S  S  N  F  M  N  T  T      p.680

          .         .         .         .         .         .       g.144565
 AACTTCCAGTCTCTTCGGCCTTTGCCATCCATTCGAATATTGGTGGATAAAATTAATCTG       c.2100
 N  F  Q  S  L  R  P  L  P  S  I  R  I  L  V  D  K  I  N  L         p.700

          .         .         .         .         .         .       g.144625
 GAACATTCAGTGCCAATGTATGCTGAACAGTTGGTGCATGTGGTCAGCAGCCTTACTCAA       c.2160
 E  H  S  V  P  M  Y  A  E  Q  L  V  H  V  V  S  S  L  T  Q         p.720

          .         .         .         .         | 16         .    g.157980
 CCTTCTGATAACCTGCTTCATTATTGTTATGTACACTGCTATCTTAAG | ATATTTGGTTTC    c.2220
 P  S  D  N  L  L  H  Y  C  Y  V  H  C  Y  L  K   | I  F  G  F      p.740

          .         .         .         .         .         .       g.158040
 CAGGCAGGACTGACGTCTTTGGATTGCAGTGGATCTTACTGCTTACCTGTACCAGTTATT       c.2280
 Q  A  G  L  T  S  L  D  C  S  G  S  Y  C  L  P  V  P  V  I         p.760

          .         .         .         .         .    | 17    .    g.180812
 CCCTCTTTCAGCACTGCTCTTTATGGGAAACTTCTGAAACTCCCCACATGCTG | GACCAAA    c.2340
 P  S  F  S  T  A  L  Y  G  K  L  L  K  L  P  T  C  W  |  T  K      p.780

          .         .         .         .         .         .       g.180872
 AGATCTCAGATTGCTATAACTGAAGGTATATTTGAACTTCCAAATCTCACAATTCAAGCT       c.2400
 R  S  Q  I  A  I  T  E  G  I  F  E  L  P  N  L  T  I  Q  A         p.800

          .         .         .         .         .         .       g.180932
 ACAAGAGCACAGACACTTCTCTTGCAAGCAATATATCAAAGTTGGTCTCATCTTGGAAAT       c.2460
 T  R  A  Q  T  L  L  L  Q  A  I  Y  Q  S  W  S  H  L  G  N         p.820

          .         .         .         .         .      | 18  .    g.262132
 GTCAGCTCTTCCGCAGTGATTGAAGCTTTGATAAATGAAATCTTCCTAAGTATAG | GTGTG    c.2520
 V  S  S  S  A  V  I  E  A  L  I  N  E  I  F  L  S  I  G |   V      p.840

          .         .         .         .         .         .       g.262192
 AAATCTAAGAATCCCCTGCCAACTCTTGAGGGCTCAATCCAGAATGTTGAATTGAAGTAC       c.2580
 K  S  K  N  P  L  P  T  L  E  G  S  I  Q  N  V  E  L  K  Y         p.860

          .         .         .         .         .         .       g.262252
 TGCAGCACATCATTGGTCAAATGTGCCTCTGGGACCATGGGATCAATAAAAATTTGTGCC       c.2640
 C  S  T  S  L  V  K  C  A  S  G  T  M  G  S  I  K  I  C  A         p.880

          . | 19       .         .         .         .         .    g.263060
 AAAGCCCCAG | TTGATAGTGGAAAAGAGAAGTTGATTCCCTTGCTTCAGGGTCCTTCTGAC    c.2700
 K  A  P  V |   D  S  G  K  E  K  L  I  P  L  L  Q  G  P  S  D      p.900

          .         .         .         .         .         .       g.263120
 ACTAAAGACCTTCATAGCACCAAGTGGCTCAATGAGAGTAGAAAGCCAGAGTCTCTCTTA       c.2760
 T  K  D  L  H  S  T  K  W  L  N  E  S  R  K  P  E  S  L  L         p.920

          .         .         .         .         .         .       g.263180
 GCTCCAGATTTGATGGCCTTCACAATCCAAGTTCCACAATATATTGACTACTGCCACAAT       c.2820
 A  P  D  L  M  A  F  T  I  Q  V  P  Q  Y  I  D  Y  C  H  N         p.940

      | 20   .         .         .         .         .         .    g.372193
 TCCG | GTGCTGTACTTCTTTGCAGTATACAAGGACTAGCAGTTAATATTGACCCAATCTTA    c.2880
 S  G |   A  V  L  L  C  S  I  Q  G  L  A  V  N  I  D  P  I  L      p.960

          .         .         .         .         .     | 21   .    g.379492
 TATACGTGGCTCATCTATCAGCCTCAGAAACGAACAAGTAGACATATGCAACAG | CAGCCT    c.2940
 Y  T  W  L  I  Y  Q  P  Q  K  R  T  S  R  H  M  Q  Q   | Q  P      p.980

          .         .         .         .         .         .       g.379552
 GTGGTAGCTGTTCCTCTTGTTATGCCAGTTTGTAGAAGGAAAGAGGATGAGGTGTCTATT       c.3000
 V  V  A  V  P  L  V  M  P  V  C  R  R  K  E  D  E  V  S  I         p.1000

          .         .         .         .         .         .       g.379612
 GGAAGTGCCCCCTTGGCAAAGCAGCAATCATATCAGGCCTCTGAATATGCCAGCAGCCCT       c.3060
 G  S  A  P  L  A  K  Q  Q  S  Y  Q  A  S  E  Y  A  S  S  P         p.1020

          .         .   | 22     .         .         .         .    g.419504
 GTAAAAACAAAAACGGTAACAG | AATCCCGCCCATTGTCAGTTCCTGTTAAAGCCATGTTG    c.3120
 V  K  T  K  T  V  T  E |   S  R  P  L  S  V  P  V  K  A  M  L      p.1040

          .         .         .         .         .         .       g.419564
 AATATATCTGAAAGCTGTAGAAGTCCTGAAGAAAGAATGAAGGAATTTATTGGAATTGTT       c.3180
 N  I  S  E  S  C  R  S  P  E  E  R  M  K  E  F  I  G  I  V         p.1060

          .         .         . | 23       .         .         .    g.430360
 TGGAATGCAGTGAAGCATCTCACACTACAG | CTTGAAGTACAATCTTGTTGTGTGTTTATT    c.3240
 W  N  A  V  K  H  L  T  L  Q   | L  E  V  Q  S  C  C  V  F  I      p.1080

          .         .         .         .         .         .       g.430420
 CCAAATGATAGCCTGCCTTCCCCAAGTACAATTGTATCTGGTGACATTCCTGGAACAGTA       c.3300
 P  N  D  S  L  P  S  P  S  T  I  V  S  G  D  I  P  G  T  V         p.1100

          .         .         .         .         .         .       g.430480
 AGAAGTTGGTACCATGGACAAACCAGCATGCCGGGAACACTTGTCCTCTGTTTGCCTCAA       c.3360
 R  S  W  Y  H  G  Q  T  S  M  P  G  T  L  V  L  C  L  P  Q         p.1120

          .         .         .         .         .         .       g.430540
 ATAAAGATTATTAGTGCTGGGCACAAGTATATGGAACCTCTGCAGGAGATTCCATTTGTT       c.3420
 I  K  I  I  S  A  G  H  K  Y  M  E  P  L  Q  E  I  P  F  V         p.1140

          .         .      | 24  .         .         .         .    g.455378
 ATCCCACGACCCATCCTTGAAGAAG | GTGATGCTTTTCCTTGGACGATCAGCTTGCATAAT    c.3480
 I  P  R  P  I  L  E  E  G |   D  A  F  P  W  T  I  S  L  H  N      p.1160

          .         .         .         .         .         .       g.455438
 TTCAGCATATATACCCTTCTTGGAAAACAAGTGACACTTTGCCTAGTGGAACCTATGGGT       c.3540
 F  S  I  Y  T  L  L  G  K  Q  V  T  L  C  L  V  E  P  M  G         p.1180

          .         .         .         .         .         .       g.455498
 TGCACCTCCACTCTAGCTGTCACGTCTCAAAAACTGCTTGCTACGGGACCTGATACACGA       c.3600
 C  T  S  T  L  A  V  T  S  Q  K  L  L  A  T  G  P  D  T  R         p.1200

          .         .         .         .         .         .       g.455558
 CATTCATTTGTTGTCTGTCTCCATGTTGACCTAGAGTCACTAGAGATAAAATGCTCTAAT       c.3660
 H  S  F  V  V  C  L  H  V  D  L  E  S  L  E  I  K  C  S  N         p.1220

        | 25 .         .         .         .         .         .    g.469582
 CCCCAG | GTCCAGCTCTTCTATGAACTAACTGATATCATGAATAAGGTCTGGAACAAGATT    c.3720
 P  Q   | V  Q  L  F  Y  E  L  T  D  I  M  N  K  V  W  N  K  I      p.1240

          .         .         .         .         .         .       g.469642
 CAGAAGAGAGGCAATCTCAACCTATCTCCAACCTCTCCAGAGACCATGGCAGGGCCTGTT       c.3780
 Q  K  R  G  N  L  N  L  S  P  T  S  P  E  T  M  A  G  P  V         p.1260

          .         .         .         .         .         .       g.469702
 CCTACTTCTCCAGTTAGAAGCAGTATAGGCACAGCTCCTCCAGATACCAGCACATGCAGC       c.3840
 P  T  S  P  V  R  S  S  I  G  T  A  P  P  D  T  S  T  C  S         p.1280

          .         .         . | 26       .         .         .    g.489646
 CCATCTGCTGACATTGGGACTACTACTGAG | GGAGATTCTATACAAGCAGGTGAGGAATCA    c.3900
 P  S  A  D  I  G  T  T  T  E   | G  D  S  I  Q  A  G  E  E  S      p.1300

          .         .         .         .         .         .       g.489706
 CCATTCTCAGATTCTGTGACCTTGGAACAAACTACAAGTAATATTGGAGGAACCAGTGGA       c.3960
 P  F  S  D  S  V  T  L  E  Q  T  T  S  N  I  G  G  T  S  G         p.1320

          .         .         .         .         .         .       g.489766
 CGTGTTAGTTTATGGATGCAGTGGGTGCTTCCCAAAATTACTATAAAGCTCTTTGCTCCA       c.4020
 R  V  S  L  W  M  Q  W  V  L  P  K  I  T  I  K  L  F  A  P         p.1340

          .         .   | 27     .         .         .         .    g.490803
 GATCCTGAAAATAAAGGCACAG | AGGTTTGTATGGTCAGTGAACTAGAAGATCTCAGTGCT    c.4080
 D  P  E  N  K  G  T  E |   V  C  M  V  S  E  L  E  D  L  S  A      p.1360

          .         .         .         .         .         .       g.490863
 TCCATAGATGTCCAGGATGTATATACCAAAGTGAAATGTAAAATAGAGAGTTTCAATATT       c.4140
 S  I  D  V  Q  D  V  Y  T  K  V  K  C  K  I  E  S  F  N  I         p.1380

          .        | 28.         .         .         .         .    g.495742
 GATCACTATAGAAGCAG | CCTTGGGGAAGAGTGTTGGTCTTTGGGGCAATGTGGAGGTGTC    c.4200
 D  H  Y  R  S  S  |  L  G  E  E  C  W  S  L  G  Q  C  G  G  V      p.1400

          .         .         .         .         .         .       g.495802
 TTCCTTTCCTGTACTGACAAGCTGAACAGACGCACCTTGTTGGTTCGACCCATCAGCAAG       c.4260
 F  L  S  C  T  D  K  L  N  R  R  T  L  L  V  R  P  I  S  K         p.1420

          .         .         .          | 29        .         .    g.499054
 CAGGACCCTTTCAGTAATTGCTCTGGCTTCTTTCCTTCT | ACAACTACAAAACTTCTAGAT    c.4320
 Q  D  P  F  S  N  C  S  G  F  F  P  S   | T  T  T  K  L  L  D      p.1440

          .         .         .         .         .         .       g.499114
 GGCACTCATCAGCAGCATGGATTCCTCTCTCTGACATACACAAAAGCTGTAACAAAAAAT       c.4380
 G  T  H  Q  Q  H  G  F  L  S  L  T  Y  T  K  A  V  T  K  N         p.1460

          .         .         .         .         .         .       g.499174
 GTCCGCCACAAGTTAACATCAAGAAATGAGCGAAGAAGTTTTCATAAGTTATCTGAAGGC       c.4440
 V  R  H  K  L  T  S  R  N  E  R  R  S  F  H  K  L  S  E  G         p.1480

          .         .         .         .         .         .       g.499234
 CTAATGGATGGTTCTCCTCATTTTCTTCATGAAATTCTTCTTTCAGCACAAGCTTTTGAT       c.4500
 L  M  D  G  S  P  H  F  L  H  E  I  L  L  S  A  Q  A  F  D         p.1500

          .         .         .         .         .         .       g.499294
 ATTGTTCTTTATTTTCCTTTACTTAATGCCATTGCAAGTATATTTCAAGCAAAACTACCA       c.4560
 I  V  L  Y  F  P  L  L  N  A  I  A  S  I  F  Q  A  K  L  P         p.1520

          .         .         .         .         .         .       g.499354
 AAGACCCAAAAAGAGAAAAGAAAATCTCCTGGTCAGCCCATGAGGACCCATACACTGACA       c.4620
 K  T  Q  K  E  K  R  K  S  P  G  Q  P  M  R  T  H  T  L  T         p.1540

          .         .         .         .         .         .       g.499414
 TCCCGCAATTTACCTTTGATTTATGTCAACACAAGTGTAATCAGAATTTTTATTCCAAAA       c.4680
 S  R  N  L  P  L  I  Y  V  N  T  S  V  I  R  I  F  I  P  K         p.1560

          .         .         | 30         .         .         .    g.508860
 ACAGAAGAAATGCAGCCAACTGTTGAAG | CTAATCAGGCAGCAAAAGAAGACACTGTGGTT    c.4740
 T  E  E  M  Q  P  T  V  E  A |   N  Q  A  A  K  E  D  T  V  V      p.1580

          .         .         .         .         .         .       g.508920
 TTGAAGATTGGCTCTGTTGCCATGGCTCCCCAGGCTGACAATCCCCTTGGCAGATCTGTC       c.4800
 L  K  I  G  S  V  A  M  A  P  Q  A  D  N  P  L  G  R  S  V         p.1600

          .         . | 31       .         .         .         .    g.544419
 CTTAGGAAAGATATTTACCA | GAGAGCCTTGAACTTAGGAATTCTTCGAGATCCTGGATCA    c.4860
 L  R  K  D  I  Y  Q  |  R  A  L  N  L  G  I  L  R  D  P  G  S      p.1620

          .         .         .         .         .         .       g.544479
 GAAATCGAAGACAGACAATACCAAATAGATCTGCAGTCCATCAATATTGGTACTGCACAG       c.4920
 E  I  E  D  R  Q  Y  Q  I  D  L  Q  S  I  N  I  G  T  A  Q         p.1640

          .         .         .         .         .         .       g.544539
 TGGCATCAACTAAAACCAGAGAAGGAAAGTGTCTCAGGAGGGGTGGTAACAGAGACTGAA       c.4980
 W  H  Q  L  K  P  E  K  E  S  V  S  G  G  V  V  T  E  T  E         p.1660

          .         .         .         .     | 32   .         .    g.563603
 AGGAATTCTCAAAATCCAGCCCTTGAGTGGAATATGGCCAGCAG | CATACGGCGGCATCAA    c.5040
 R  N  S  Q  N  P  A  L  E  W  N  M  A  S  S  |  I  R  R  H  Q      p.1680

          .         .         .         .         .         .       g.563663
 GAAAGGAGAGCAATTTTGACCCCCGTTTTGACAGATTTTTCTGTCCGAATAACTGGAGCA       c.5100
 E  R  R  A  I  L  T  P  V  L  T  D  F  S  V  R  I  T  G  A         p.1700

          .         .         .         .         .  | 33      .    g.565428
 CCTGCTGTCATTTTCACCAAAGTAGTTTCTCCAGAAAATTTGCATACTGAG | GAGATTTTA    c.5160
 P  A  V  I  F  T  K  V  V  S  P  E  N  L  H  T  E   | E  I  L      p.1720

          .         .         .         .         .         .       g.565488
 GTGTGTGGCCATTCCTTAGAAGTGAATATAACCACAAACCTGGACTTCTTCCTAAGTGTG       c.5220
 V  C  G  H  S  L  E  V  N  I  T  T  N  L  D  F  F  L  S  V         p.1740

          .         .         .         .         .         .       g.565548
 GCTCAAGTTCAACTCTTACATCAGTTAATAGTAGCAAATATGACTGGACTGGAACCATCA       c.5280
 A  Q  V  Q  L  L  H  Q  L  I  V  A  N  M  T  G  L  E  P  S         p.1760

          .      | 34  .         .         .         .         .    g.629785
 AACAAGGCTGCAGAG | ATCTCTAAACAAGAACAGAAAAAAGTGGATATATTTGATGGAGGC    c.5340
 N  K  A  A  E   | I  S  K  Q  E  Q  K  K  V  D  I  F  D  G  G      p.1780

          .         .         .         .         .         .       g.629845
 ATGGCTGAAACCTCATCTCGCTACAGTGGTGCTCAGGATAGTGGAATTGGCAGTGACAGT       c.5400
 M  A  E  T  S  S  R  Y  S  G  A  Q  D  S  G  I  G  S  D  S         p.1800

          .         .         .         .         .         .       g.629905
 GTTAAAATCAGAATAGTGCAAATAGAGCAGCACAGTGGTGCCAGTCAGCATCGCATTGCC       c.5460
 V  K  I  R  I  V  Q  I  E  Q  H  S  G  A  S  Q  H  R  I  A         p.1820

          .         .         .         .         .         .       g.629965
 CGTCCCTCACGCCAGTCATCAATTGTAAAAAATCTAAATTTTATTCCCTTTGACATATTT       c.5520
 R  P  S  R  Q  S  S  I  V  K  N  L  N  F  I  P  F  D  I  F         p.1840

          .         .         .         .         .         .       g.630025
 ATTACTGCAAGTAGAATCTCACTAATGACCTATTCCTGTATGGCCTTATCCAAATCGAAA       c.5580
 I  T  A  S  R  I  S  L  M  T  Y  S  C  M  A  L  S  K  S  K         p.1860

          .         .         .         .         .         .       g.630085
 TCACAAGAACAGAAGAATAATGAAAAAACAGACAAGAGTTCATTAAATCTCCCAGAAGTT       c.5640
 S  Q  E  Q  K  N  N  E  K  T  D  K  S  S  L  N  L  P  E  V         p.1880

          .         .         .         .         .         .       g.630145
 GATTCAGATGTTGCTAAGCCCAACCAGGCATGTATTTCCACGGTGACAGCAGAAGATCTC       c.5700
 D  S  D  V  A  K  P  N  Q  A  C  I  S  T  V  T  A  E  D  L         p.1900

          .         .         .         .         .         .       g.630205
 TTAAGGAGCAGCATTTCTTTTCCTTCAGGGAAAAAAATAGGGGTCCTCTCTCTTGAAAGT       c.5760
 L  R  S  S  I  S  F  P  S  G  K  K  I  G  V  L  S  L  E  S         p.1920

          .         .         .         .         .         .       g.630265
 CTTCATGCATCCACAAGGTCATCTGCTAGACAAGCACTTGGTATAACTATTGTTCGGCAG       c.5820
 L  H  A  S  T  R  S  S  A  R  Q  A  L  G  I  T  I  V  R  Q         p.1940

          .         .         .         .         .         .       g.630325
 CCTGGTCGAAGAGGAACTGGTGACTTACAGCTAGAGCCTTTTCTGTACTTTATTGTGTCC       c.5880
 P  G  R  R  G  T  G  D  L  Q  L  E  P  F  L  Y  F  I  V  S         p.1960

          .         .         .         .         .         .       g.630385
 CAGCCTTCCTTGCTTCTGAGTTGTCACCACAGAAAGCAGCGAGTGGAAGTATCCATTTTT       c.5940
 Q  P  S  L  L  L  S  C  H  H  R  K  Q  R  V  E  V  S  I  F         p.1980

          .         .         .         .    | 35    .         .    g.649300
 GATGCTGTGCTTAAAGGGGTGGCCTCTGATTACAAATGTATAG | ATCCTGGGAAGACTCTG    c.6000
 D  A  V  L  K  G  V  A  S  D  Y  K  C  I  D |   P  G  K  T  L      p.2000

          .         .         .         .         .         .       g.649360
 CCTGAAGCCCTTGATTATTGCACTGTTTGGCTACAGACAGTGCCTGGAGAAATAGACAGC       c.6060
 P  E  A  L  D  Y  C  T  V  W  L  Q  T  V  P  G  E  I  D  S         p.2020

          .         .         .         .         .         .       g.649420
 AAAAGTGGTATTCCACCTTCCTTTATAACACTACAGATTAAAGACTTTCTGAATGGACCA       c.6120
 K  S  G  I  P  P  S  F  I  T  L  Q  I  K  D  F  L  N  G  P         p.2040

   | 36      .         .         .         .         .         .    g.687513
 G | CGGATGTCAATTTGGATATATCAAAGCCTTTGAAAGCAAACCTGAGTTTCACCAAACTG    c.6180
 A |   D  V  N  L  D  I  S  K  P  L  K  A  N  L  S  F  T  K  L      p.2060

          .         .         .         .         .         .       g.687573
 GATCAGATAAACCTTTTTTTAAAGAAGATAAAAAATGCACACAGTTTGGCACATAGTGAA       c.6240
 D  Q  I  N  L  F  L  K  K  I  K  N  A  H  S  L  A  H  S  E         p.2080

          .         .         .         .         .         .       g.687633
 GAGACTTCAGCCATGTCCAACACCATGGTGAATAAGGATGATCTTCCAGTCTCCAAATAT       c.6300
 E  T  S  A  M  S  N  T  M  V  N  K  D  D  L  P  V  S  K  Y         p.2100

          .         .         .         .         .         .       g.687693
 TACCGTGGAAAGTTGTCTAAACCCAAAATTCATGGTGATGGAGTGCAAAAGATTTCAGCT       c.6360
 Y  R  G  K  L  S  K  P  K  I  H  G  D  G  V  Q  K  I  S  A         p.2120

          .         .         .         .         .         .       g.687753
 CAAGAAAACATGTGGAGAGCTGTTTCCTGCTTTCAAAAAATTTCTGTTCAAACTACTCAG       c.6420
 Q  E  N  M  W  R  A  V  S  C  F  Q  K  I  S  V  Q  T  T  Q         p.2140

          .         .         .         .         .         .       g.687813
 ATTGTGATCTCCATGGAAACTGTACCCCATACCAGCAAACCATGCCTGTTAGCATCTCTC       c.6480
 I  V  I  S  M  E  T  V  P  H  T  S  K  P  C  L  L  A  S  L         p.2160

          .         .         .         .          | 37        .    g.705111
 TCAAACCTCAATGGAAGCCTTAGTGTCAAGGCAACACAAAAAGTACCTG | GCATAATTCTT    c.6540
 S  N  L  N  G  S  L  S  V  K  A  T  Q  K  V  P  G |   I  I  L      p.2180

          .         .         .         .         .         .       g.705171
 GGGTCATCATTTCTACTCAGTATAAACGATTTTCTCCTTAAAACAAGTCTCAAAGAAAGA       c.6600
 G  S  S  F  L  L  S  I  N  D  F  L  L  K  T  S  L  K  E  R         p.2200

          .         .         .         .         .         .       g.705231
 AGCCGCATTCTGATAGGACCATGTTGTGCTACTGCCAATCTGGAAGCTAAGTGGTGTAAA       c.6660
 S  R  I  L  I  G  P  C  C  A  T  A  N  L  E  A  K  W  C  K         p.2220

          .         .         .         .         .         .       g.705291
 CACAGCGGGAATCCAGGCCCAGAACAATCCATACCAAAAATATCCATTGACTTAAGAGGA       c.6720
 H  S  G  N  P  G  P  E  Q  S  I  P  K  I  S  I  D  L  R  G         p.2240

          .   | 38     .         .         .         .         .    g.708322
 GGTCTACTACAG | GTCTTCTGGGGTCAAGAACATTTGAATTGTTTAGTTCTTCTACATGAA    c.6780
 G  L  L  Q   | V  F  W  G  Q  E  H  L  N  C  L  V  L  L  H  E      p.2260

          .         .         .         .         .         .       g.708382
 TTACTCAATGGATACCTTAATGAGGAGGGAAATTTTGAAGTACAAGTTTCTGAACCAGTG       c.6840
 L  L  N  G  Y  L  N  E  E  G  N  F  E  V  Q  V  S  E  P  V         p.2280

          .         .         .         .         .         .       g.708442
 CCTCAAATGTCATCTCCTGTGGAAAAGAATCAGACATTTAAAAGTGAACAAAGTTCAGAT       c.6900
 P  Q  M  S  S  P  V  E  K  N  Q  T  F  K  S  E  Q  S  S  D         p.2300

          .         .         .         . | 39       .         .    g.708812
 GACCTACGGACAGGTCTATTTCAGTATGTACAGGATGCTG | AATCTTTGAAATTGCCTGGG    c.6960
 D  L  R  T  G  L  F  Q  Y  V  Q  D  A  E |   S  L  K  L  P  G      p.2320

          .         .         .         .         .         .       g.708872
 GTCTATGAAGTCTTATTTTATAATGAAACTGAAGATTGCCCAGGGATGATGTTATGGAGA       c.7020
 V  Y  E  V  L  F  Y  N  E  T  E  D  C  P  G  M  M  L  W  R         p.2340

          .         .         .         .         .         .       g.708932
 TATCCAGAACCTAGAGTACTCACCCTTGTACGAATAACTCCTGTACCTTTTAACACCACA       c.7080
 Y  P  E  P  R  V  L  T  L  V  R  I  T  P  V  P  F  N  T  T         p.2360

          .         .         .         .      | 40  .         .    g.754718
 GAGGATCCAGATATTAGCACAGCAGACCTTGGTGATGTGCTACAG | GTTCCTTGTAGCTTG    c.7140
 E  D  P  D  I  S  T  A  D  L  G  D  V  L  Q   | V  P  C  S  L      p.2380

          .         .         .         .         .         .       g.754778
 GAATACTGGGATGAACTCCAGAAGGTTTTTGTTGCATTTAGAGAATTTAATCTGTCTGAA       c.7200
 E  Y  W  D  E  L  Q  K  V  F  V  A  F  R  E  F  N  L  S  E         p.2400

          .         .         .         .         .         .       g.754838
 AGCAAAGTTTGTGAACTGCAGTTGCCGGATATCAATCTCGTGAATGACCAGAAGAAATTA       c.7260
 S  K  V  C  E  L  Q  L  P  D  I  N  L  V  N  D  Q  K  K  L         p.2420

          .         .         .         .         .         .       g.754898
 GTATCTTCAGATCTTTGGAGAATTGTCTTGAACAGCAGTCAAAATGGAGCTGATGACCAA       c.7320
 V  S  S  D  L  W  R  I  V  L  N  S  S  Q  N  G  A  D  D  Q         p.2440

    | 41     .         .         .         .         .         .    g.764762
 AG | CTCTGCAAGTGAGTCTGGTTCTCAAAGCACTTGTGATCCACTTGTGACTCCAACAGCC    c.7380
 S  |  S  A  S  E  S  G  S  Q  S  T  C  D  P  L  V  T  P  T  A      p.2460

          .         .         .         .         .         .       g.764822
 CTGGCTGCCTGTACCAGAGTTGACTCCTGCTTTACCCCATGGTTTGTCCCATCCCTTTGC       c.7440
 L  A  A  C  T  R  V  D  S  C  F  T  P  W  F  V  P  S  L  C         p.2480

          .         .         .         .         .         .       g.764882
 GTTTCTTTCCAGTTTGCTCACCTGGAATTCCATCTTTGTCATCACCTTGACCAACTAGGC       c.7500
 V  S  F  Q  F  A  H  L  E  F  H  L  C  H  H  L  D  Q  L  G         p.2500

      | 42   .         .         .         .         .         .    g.766667
 ACAG | CTGCACCACAGTACCTACAGCCATTTGTTTCCGACAGAAATATGCCATCTGAACTA    c.7560
 T  A |   A  P  Q  Y  L  Q  P  F  V  S  D  R  N  M  P  S  E  L      p.2520

          .         .         .         .         .         .       g.766727
 GAATACATGATTGTTTCCTTCAGAGAACCACACATGTATCTTCGACAGTGGAATAATGGT       c.7620
 E  Y  M  I  V  S  F  R  E  P  H  M  Y  L  R  Q  W  N  N  G         p.2540

          .         .         .         .         .         .       g.766787
 TCTGTCTGTCAGGAGATCCAGTTCTTAGCTCAAGCAGACTGTAAACTTCTAGAGTGCAGA       c.7680
 S  V  C  Q  E  I  Q  F  L  A  Q  A  D  C  K  L  L  E  C  R         p.2560

          .         .         .         .         .         .       g.766847
 AATGTCACTATGCAAAGTGTGGTGAAACCCTTCAGCATCTTCGGGCAGATGGCAGTTTCC       c.7740
 N  V  T  M  Q  S  V  V  K  P  F  S  I  F  G  Q  M  A  V  S         p.2580

          .         .         .         .         .         .       g.766907
 AGCGATGTAGTGGAAAAGCTGCTTGACTGCACCGTGATAGTTGATTCTGTATTTGTAAAC       c.7800
 S  D  V  V  E  K  L  L  D  C  T  V  I  V  D  S  V  F  V  N         p.2600

          .         .         .         .         .     | 43   .    g.772250
 CTTGGACAGCATGTAGTCCATTCACTAAACACTGCAATACAAGCTTGGCAACAG | AACAAA    c.7860
 L  G  Q  H  V  V  H  S  L  N  T  A  I  Q  A  W  Q  Q   | N  K      p.2620

          .         .         .         .         .         .       g.772310
 TGCCCTGAGGTAGAGGAGTTGGTCTTCAGCCATTTTGTGATCTGTAATGACACACAGGAG       c.7920
 C  P  E  V  E  E  L  V  F  S  H  F  V  I  C  N  D  T  Q  E         p.2640

          .         .         .         .         .         .       g.772370
 ACACTGCGGTTTGGCCAGGTGGATACTGATGAAAATATTCTGCTGGCGAGTCTCCACAGT       c.7980
 T  L  R  F  G  Q  V  D  T  D  E  N  I  L  L  A  S  L  H  S         p.2660

          .         .         .       | 44 .         .         .    g.797328
 CACCAGTACAGCTGGCGCTCTCACAAATCCCCACAG | CTGTTACACATCTGTATTGAAGGT    c.8040
 H  Q  Y  S  W  R  S  H  K  S  P  Q   | L  L  H  I  C  I  E  G      p.2680

          .         .         .         .         .         .       g.797388
 TGGGGCAACTGGCGTTGGTCAGAGCCTTTCAGTGTGGACCATGCCGGGACTTTTATTAGA       c.8100
 W  G  N  W  R  W  S  E  P  F  S  V  D  H  A  G  T  F  I  R         p.2700

          .         .         .         .         .         .       g.797448
 ACAATTCAGTACAGGGGTCGAACTGCTTCTCTCATCATCAAGGTTCAGCAACTCAATGGA       c.8160
 T  I  Q  Y  R  G  R  T  A  S  L  I  I  K  V  Q  Q  L  N  G         p.2720

          .   | 45     .         .         .         .         .    g.805517
 GTACAAAAACAG | ATTATCATCTGTGGAAGACAGATCATCTGTAGTTACTTGTCTCAAAGC    c.8220
 V  Q  K  Q   | I  I  I  C  G  R  Q  I  I  C  S  Y  L  S  Q  S      p.2740

          .         .         .         .         .         .       g.805577
 ATAGAACTAAAAGTCGTTCAGCATTACATTGGTCAAGATGGACAAGCTGTAGTTCGGGAA       c.8280
 I  E  L  K  V  V  Q  H  Y  I  G  Q  D  G  Q  A  V  V  R  E         p.2760

          .         .         .         .         .         .       g.805637
 CATTTTGACTGCCTCACAGCCAAACAGAAATTGCCTTCGTACATACTAGAAAACAATGAA       c.8340
 H  F  D  C  L  T  A  K  Q  K  L  P  S  Y  I  L  E  N  N  E         p.2780

          .         .         .         .         .         .       g.805697
 CTGACGGAGCTGTGTGTGAAGGCCAAAGGAGATGAAGACTGGTCAAGAGATGTGTGCCTG       c.8400
 L  T  E  L  C  V  K  A  K  G  D  E  D  W  S  R  D  V  C  L         p.2800

          .         .         .       | 46 .         .         .    g.806404
 GAATCCAAAGCCCCTGAGTACAGCATTGTCATTCAG | GTGCCATCTTCAAACAGTTCCATT    c.8460
 E  S  K  A  P  E  Y  S  I  V  I  Q   | V  P  S  S  N  S  S  I      p.2820

          .         .         .         .         .         .       g.806464
 ATTTATGTCTGGTGCACAGTTTTGACTTTAGAACCCAACTCTCAAGTGCAACAACGAATG       c.8520
 I  Y  V  W  C  T  V  L  T  L  E  P  N  S  Q  V  Q  Q  R  M         p.2840

  | 47       .         .         .         .         .         .    g.806702
  | ATTGTGTTCAGCCCTCTTTTTATCATGAGGAGTCATCTTCCAGACCCCATTATCATACAT    c.8580
  | I  V  F  S  P  L  F  I  M  R  S  H  L  P  D  P  I  I  I  H      p.2860

          .         .         .         .         .         .       g.806762
 TTGGAGAAAAGGAGTCTGGGATTGAGTGAAACACAAATTATTCCAGGAAAAGGGCAGGAA       c.8640
 L  E  K  R  S  L  G  L  S  E  T  Q  I  I  P  G  K  G  Q  E         p.2880

          .         .         .         .         .       | 48 .    g.807345
 AAACCACTGCAAAACATAGAACCTGACCTTGTACATCACCTGACATTCCAAGCAAG | AGAA    c.8700
 K  P  L  Q  N  I  E  P  D  L  V  H  H  L  T  F  Q  A  R  |  E      p.2900

          .         .         .         .         .         .       g.807405
 GAATATGATCCTTCAGATTGTGCAGTTCCCATCTCAACATCCCTCATTAAGCAAATAGCC       c.8760
 E  Y  D  P  S  D  C  A  V  P  I  S  T  S  L  I  K  Q  I  A         p.2920

          .         .         .         .         .         .       g.807465
 ACTAAGGTACACCCTGGAGGCACAGTTAATCAGATCCTTGACGAATTCTATGGGCCAGAA       c.8820
 T  K  V  H  P  G  G  T  V  N  Q  I  L  D  E  F  Y  G  P  E         p.2940

          .         .         .         .        | 49.         .    g.807863
 AAGTCGCTTCAACCCATATGGCCCTATAATAAGAAGGATTCTGACAG | GAATGAACAGCTA    c.8880
 K  S  L  Q  P  I  W  P  Y  N  K  K  D  S  D  R  |  N  E  Q  L      p.2960

          .         .         .         .         .         .       g.807923
 AGTCAGTGGGATAGCCCAATGCGAGTGAAGCTGTCAATCTGGAAGCCATATGTTAGAACT       c.8940
 S  Q  W  D  S  P  M  R  V  K  L  S  I  W  K  P  Y  V  R  T         p.2980

          .         .         .         .         .         .       g.807983
 TTGTTGATAGAACTTCTGCCCTGGGCCCTGCTTATCAATGAATCCAAATGGGACCTCTGG       c.9000
 L  L  I  E  L  L  P  W  A  L  L  I  N  E  S  K  W  D  L  W         p.3000

          .         .         .         .         .         .       g.808043
 CTATTTGAAGGAGAGAAAATTGTTCTACAGGTTCCTGCTGGCAAAATTATTATTCCTCCT       c.9060
 L  F  E  G  E  K  I  V  L  Q  V  P  A  G  K  I  I  I  P  P         p.3020

           | 50        .         .         .         .         .    g.809274
 AATTTTCAG | GAAGCTTTTCAAATTGGAATATACTGGGCAAATACAAACACTGTGCACAAG    c.9120
 N  F  Q   | E  A  F  Q  I  G  I  Y  W  A  N  T  N  T  V  H  K      p.3040

          .         .         .         .         .         .       g.809334
 TCAGTAGCAATTAAACTGGTCCATAACCTGACATCTCCAAAGTGGAAAGATGGAGGTAAT       c.9180
 S  V  A  I  K  L  V  H  N  L  T  S  P  K  W  K  D  G  G  N         p.3060

          .         .         .         .         .         .       g.809394
 GGTGAAGTTGTGACACTGGATGAAGAAGCGTTTGTTGATACTGAAATAAGACTTGGTGCT       c.9240
 G  E  V  V  T  L  D  E  E  A  F  V  D  T  E  I  R  L  G  A         p.3080

          .         | 51         .         .         .         .    g.811803
 TTTCCAGGACATCAGAAG | TTATGTCAGTTCTGCATTTCCTCCATGGTACAGCAAGGTATA    c.9300
 F  P  G  H  Q  K   | L  C  Q  F  C  I  S  S  M  V  Q  Q  G  I      p.3100

          .         .         .         .         .         .       g.811863
 CAAATTATTCAGATTGAAGACAAGACTACAATAATCAATAATACACCATATCAAATATTT       c.9360
 Q  I  I  Q  I  E  D  K  T  T  I  I  N  N  T  P  Y  Q  I  F         p.3120

          .         .         .         .      | 52  .         .    g.820313
 TATAAACCACAGCTATCTGTCTGCAATCCCCATTCTGGAAAGGAG | TATTTTCGTGTTCCA    c.9420
 Y  K  P  Q  L  S  V  C  N  P  H  S  G  K  E   | Y  F  R  V  P      p.3140

          .         .         .         .         .         .       g.820373
 GACAGTGCTACTTTTAGCATTTGCCCAGGTGGAGAGCAGCCTGCTATGAAATCCAGCTCC       c.9480
 D  S  A  T  F  S  I  C  P  G  G  E  Q  P  A  M  K  S  S  S         p.3160

          .         .         .         .         .         .       g.820433
 CTTCCTTGCTGGGACTTGATGCCTGACATCAGTCAGTCAGTACTGGATGCATCCCTGCTT       c.9540
 L  P  C  W  D  L  M  P  D  I  S  Q  S  V  L  D  A  S  L  L         p.3180

          .         .         .         .         .         .       g.820493
 CAGAAACAGATCATGCTGGGCTTTTCTCCTGCCCCAGGTGCTGACAGCTCACAGTGCTGG       c.9600
 Q  K  Q  I  M  L  G  F  S  P  A  P  G  A  D  S  S  Q  C  W         p.3200

          .         .         .         .         .         .       g.820553
 AGCCTGCCAGCTATAGTTAGACCAGAGTTTCCCAGACAGAGTGTGGCAGTACCCCTCGGG       c.9660
 S  L  P  A  I  V  R  P  E  F  P  R  Q  S  V  A  V  P  L  G         p.3220

          .         .          | 53        .         .         .    g.823157
 AATTTCCGGGAAAATGGATTCTGTACCAG | GGCTATAGTGCTGACATATCAAGAACACCTC    c.9720
 N  F  R  E  N  G  F  C  T  R  |  A  I  V  L  T  Y  Q  E  H  L      p.3240

          .         .         .         .         .         .       g.823217
 GGAGTGACTTATTTAACCCTCTCAGAAGACCCTAGTCCTCGAGTAATTATCCACAATAGA       c.9780
 G  V  T  Y  L  T  L  S  E  D  P  S  P  R  V  I  I  H  N  R         p.3260

          .         .         .        | 54.         .         .    g.823491
 TGTCCAGTAAAAATGCTTATAAAGGAAAACATTAAAG | ATATTCCAAAGTTTGAGGTTTAT    c.9840
 C  P  V  K  M  L  I  K  E  N  I  K  D |   I  P  K  F  E  V  Y      p.3280

          .         .         .         .         .         .       g.823551
 TGCAAAAAAATTCCCTCCGAGTGCTCAATTCATCATGAGCTGTATCATCAGATTTCCAGT       c.9900
 C  K  K  I  P  S  E  C  S  I  H  H  E  L  Y  H  Q  I  S  S         p.3300

          .         .         .         .         .         .       g.823611
 TATCCGGACTGCAAGACCAAAGACTTACTTCCAAGCCTACTTTTGAGAGTTGAACCTCTA       c.9960
 Y  P  D  C  K  T  K  D  L  L  P  S  L  L  L  R  V  E  P  L         p.3320

          .         .         .         .         .        | 55.    g.836708
 GATGAAGTAACAACTGAGTGGAGTGATGCCATTGACATCAACAGTCAGGGAACACAG | GTT    c.10020
 D  E  V  T  T  E  W  S  D  A  I  D  I  N  S  Q  G  T  Q   | V      p.3340

          .         .         .         .         .         .       g.836768
 GTGTTCCTGACTGGCTTTGGCTATGTGTATGTGGATGTTGTACATCAGTGTGGCACAGTC       c.10080
 V  F  L  T  G  F  G  Y  V  Y  V  D  V  V  H  Q  C  G  T  V         p.3360

          .         .         .         .         .       | 56 .    g.841384
 TTCATCACTGTGGCCCCAGAAGGAAAAGCAGGACCTATTTTAACCAATACCAACAG | AGCG    c.10140
 F  I  T  V  A  P  E  G  K  A  G  P  I  L  T  N  T  N  R  |  A      p.3380

          .         .         .         .         .         .       g.841444
 CCAGAGAAGATTGTTACATTTAAAATGTTCATCACTCAGTTAAGCCTGGCAGTGTTTGAT       c.10200
 P  E  K  I  V  T  F  K  M  F  I  T  Q  L  S  L  A  V  F  D         p.3400

          .         .         .         .         .         .       g.841504
 GACCTCACCCACCACAAAGCATCAGCTGAGCTTCTGAGACTCACACTGGACAACATTTTT       c.10260
 D  L  T  H  H  K  A  S  A  E  L  L  R  L  T  L  D  N  I  F         p.3420

          .         .         .         .         .         .       g.841564
 CTCTGTGTGGCCCCGGGAGCTGGTCCCCTCCCTGGGGAAGAGCCTGTGGCTGCGTTGTTT       c.10320
 L  C  V  A  P  G  A  G  P  L  P  G  E  E  P  V  A  A  L  F         p.3440

          .         .         .         .         .         .       g.841624
 GAACTTTACTGTGTGGAGATCTGCTGTGGGGACCTGCAGCTAGACAACCAGCTTTATAAC       c.10380
 E  L  Y  C  V  E  I  C  C  G  D  L  Q  L  D  N  Q  L  Y  N         p.3460

          .         .         .         .         .         .       g.841684
 AAGTCCAATTTCCACTTTGCTGTCTTAGTCTGCCAGGGAGAAAAAGCAGAACCCATTCAG       c.10440
 K  S  N  F  H  F  A  V  L  V  C  Q  G  E  K  A  E  P  I  Q         p.3480

          .         .         .         .         .         .       g.841744
 TGTTCCAAAATGCAGAGTCTCCTCATATCCAACAAAGAGTTGGAAGAATACAAGGAAAAA       c.10500
 C  S  K  M  Q  S  L  L  I  S  N  K  E  L  E  E  Y  K  E  K         p.3500

          .         .         .         .         .         .       g.841804
 TGTTTTATCAAACTTTGCATCACCTTAAATGAAGGCAAGAGCATCCTCTGTGATATTAAT       c.10560
 C  F  I  K  L  C  I  T  L  N  E  G  K  S  I  L  C  D  I  N         p.3520

          .         .         .         .         .         .       g.841864
 GAGTTCAGCTTTGAATTAAAACCTGCTCGGTTATACGTGGAAGACACATTTGTATACTAC       c.10620
 E  F  S  F  E  L  K  P  A  R  L  Y  V  E  D  T  F  V  Y  Y         p.3540

          .         .         .         .         .         .       g.841924
 ATCAAGACTTTGTTTGACACCTACCTTCCTAACAGCAGGTTGGCTGGTCACTCCACACAC       c.10680
 I  K  T  L  F  D  T  Y  L  P  N  S  R  L  A  G  H  S  T  H         p.3560

          .         .         .         .         .         .       g.841984
 CTCTCCGGGGGTAAACAGGTGTTGCCCATGCAGGTCACACAGCACGCCAGGGCCTTGGTG       c.10740
 L  S  G  G  K  Q  V  L  P  M  Q  V  T  Q  H  A  R  A  L  V         p.3580

          .         .         .         .         .         .       g.842044
 AATCCTGTGAAGTTACGGAAACTGGTGATCCAGCCAGTAAATTTGCTCGTCAGCATCCAC       c.10800
 N  P  V  K  L  R  K  L  V  I  Q  P  V  N  L  L  V  S  I  H         p.3600

          .         .         .         .         .         .       g.842104
 GCTTCCCTCAAGCTGTACATAGCCTCAGACCACACTCCTCTCTCCTTCTCGGTGTTTGAA       c.10860
 A  S  L  K  L  Y  I  A  S  D  H  T  P  L  S  F  S  V  F  E         p.3620

          .         .         .         .         .         .       g.842164
 AGAGGACCCATCTTCACCACTGCGAGGCAGCTTGTGCACGCCCTGGCAATGCACTATGCC       c.10920
 R  G  P  I  F  T  T  A  R  Q  L  V  H  A  L  A  M  H  Y  A         p.3640

          .         .   | 57     .         .         .         .    g.847271
 GCTGGGGCCCTTTTTAGAGCAG | GCTGGGTAGTTGGGTCTCTGGATATTCTTGGCAGCCCT    c.10980
 A  G  A  L  F  R  A  G |   W  V  V  G  S  L  D  I  L  G  S  P      p.3660

          .         .         .         .         .         .       g.847331
 GCAAGCCTGGTGAGAAGCATCGGGAACGGGGTCGCCGACTTCTTCAGGCTTCCGTATGAG       c.11040
 A  S  L  V  R  S  I  G  N  G  V  A  D  F  F  R  L  P  Y  E         p.3680

          .         .         .         .         .         .       g.847391
 GGGCTGACCCGGGGCCCTGGAGCCTTCGTGAGTGGCGTCTCCAGAGGGACCACATCGTTT       c.11100
 G  L  T  R  G  P  G  A  F  V  S  G  V  S  R  G  T  T  S  F         p.3700

          .          | 58        .         .         .         .    g.849746
 GTAAAGCACATCTCCAAAG | GTACCCTCACATCCATCACCAACCTCGCCACAAGCCTGGCC    c.11160
 V  K  H  I  S  K  G |   T  L  T  S  I  T  N  L  A  T  S  L  A      p.3720

          .         .         .         .         .         .       g.849806
 CGGAACATGGACCGGCTCTCACTGGATGAGGAGCACTACAACCGGCAGGAGGAGTGGCGG       c.11220
 R  N  M  D  R  L  S  L  D  E  E  H  Y  N  R  Q  E  E  W  R         p.3740

          .         .         .         .         .         .       g.849866
 CGGCAGCTCCCCGAGAGCCTGGGCGAGGGGCTTCGACAGGGCCTGTCCCGGCTGGGCATC       c.11280
 R  Q  L  P  E  S  L  G  E  G  L  R  Q  G  L  S  R  L  G  I         p.3760

          . | 59       .         .         .         .         .    g.856268
 AGCCTGCTTG | GTGCAATTGCTGGTATAGTTGATCAGCCGATGCAGAACTTCCAGAAAACA    c.11340
 S  L  L  G |   A  I  A  G  I  V  D  Q  P  M  Q  N  F  Q  K  T      p.3780

          .         .         .         .         .         .       g.856328
 TCTGAGGCACAGGCTTCAGCAGGACACAAGGCCAAGGGTGTCATCTCGGGTGTGGGGAAA       c.11400
 S  E  A  Q  A  S  A  G  H  K  A  K  G  V  I  S  G  V  G  K         p.3800

          .         .         .         .         .         .       g.856388
 GGAATCATGGGGGTGTTCACAAAGCCCATCGGAGGAGCTGCTGAGCTGGTGTCACAGACT       c.11460
 G  I  M  G  V  F  T  K  P  I  G  G  A  A  E  L  V  S  Q  T         p.3820

         | 60.         .         .         .         .         .    g.858767
 GGCTATG | GTATTTTACATGGAGCTGGACTTTCTCAGCTTCCCAAACAGCGCCATCAGCCA    c.11520
 G  Y  G |   I  L  H  G  A  G  L  S  Q  L  P  K  Q  R  H  Q  P      p.3840

          .         .         .         .         . | 61       .    g.859387
 AGTGATCTACATGCTGACCAGGCTCCAAACAGCCATGTCAAATATGTCTG | GAAAATGCTT    c.11580
 S  D  L  H  A  D  Q  A  P  N  S  H  V  K  Y  V  W  |  K  M  L      p.3860

          .         .         .         .         .         .       g.859447
 CAGTCTCTGGGCAGACCAGAAGTCCACATGGCCCTGGACGTGGTTCTGGTGAGGGGCTCA       c.11640
 Q  S  L  G  R  P  E  V  H  M  A  L  D  V  V  L  V  R  G  S         p.3880

          .         .         .         .         .         .       g.859507
 GGCCAGGAGCATGAAGGGTGCTTGCTGCTGACATCAGAAGTGCTCTTCGTGGTGAGTGTC       c.11700
 G  Q  E  H  E  G  C  L  L  L  T  S  E  V  L  F  V  V  S  V         p.3900

          .         .         .         .         .         .       g.859567
 AGTGAGGACACACAGCAGCAGGCCTTCCCCGTCACAGAAATCGACTGTGCACAGGACAGC       c.11760
 S  E  D  T  Q  Q  Q  A  F  P  V  T  E  I  D  C  A  Q  D  S         p.3920

          .         .         .         .         .         .       g.859627
 AAGCAGAACAACTTACTCACAGTGCAGCTCAAGCAGCCAAGAGTGGCCTGTGATGTGGAG       c.11820
 K  Q  N  N  L  L  T  V  Q  L  K  Q  P  R  V  A  C  D  V  E         p.3940

  | 62       .         .         .         .         .         .    g.863407
  | GTAGATGGAGTCCGAGAGAGACTGTCAGAGCAACAGTACAACAGACTGGTGGACTACATC    c.11880
  | V  D  G  V  R  E  R  L  S  E  Q  Q  Y  N  R  L  V  D  Y  I      p.3960

          .         .         .         .         .         .       g.863467
 ACAAAGACATCTTGTCACCTGGCCCCCAGCTGTTCTTCCATGCAAATACCATGCCCTGTG       c.11940
 T  K  T  S  C  H  L  A  P  S  C  S  S  M  Q  I  P  C  P  V         p.3980

          .         .         .         .         .         .       g.863527
 GTGGCTGCAGAACCTCCCCCCTCCACTGTTAAAACATACCATTACCTGGTTGATCCACAT       c.12000
 V  A  A  E  P  P  P  S  T  V  K  T  Y  H  Y  L  V  D  P  H         p.4000

          .         .         .         .         .         .       g.863587
 TTTGCTCAGGTCTTCCTTAGTAAATTTACCATGGTGAAAAATAAAGCCCTGAGGAAAGGG       c.12060
 F  A  Q  V  F  L  S  K  F  T  M  V  K  N  K  A  L  R  K  G         p.4020

                                                                    g.863596
 TTTCCTTGA                                                          c.12069
 F  P  X                                                            p.4022

          .         .         .         .         .         .       g.863656
 gtcccctctgaggtgtttattcctgcttgtgtgatttagtttttgggtttctttgagaca       c.*60

          .         .         .         .         .         .       g.863716
 gggtctcactgcattgcccttgctgacctcaaattctggggttcaagcaatcctcccacc       c.*120

          .         .         .         .         .         .       g.863776
 tcaacccacaagtagctacgactgcaagcacctgccaccataaagggctgcattttgcca       c.*180

          .         .         .         .         .         .       g.863836
 ccataaagggctgcatttttttaaaaagcctaggcagctctaacatcatctgatatggac       c.*240

          .         .         .         .         .         .       g.863896
 acaaggccaacagtttccttatttacatccttacctctaaaagatacttcaaagtgacaa       c.*300

          .         .         .         .         .         .       g.863956
 aaacgtgttccttccccacttagagacaatgattaacagggccctatatgttcttaccac       c.*360

          .         .         .         .         .         .       g.864016
 atacagaggatgcatttatttttgctctatgacacttgcaaaaatctctactgtaattaa       c.*420

          .         .         .         .         .         .       g.864076
 tttgggtctattattaactctctgttccatcatagaatgtggccaggccttacaatggag       c.*480

          .         .         .         .         .         .       g.864136
 agccagagttaaaacttcaagttgcatctgtttttgggctgagtcaccacctttgcctca       c.*540

          .         .         .         .         .         .       g.864196
 tgctcctttgtctgcaaaggcctaggattctttctttaaatgaaatgcttaggactttgt       c.*600

          .         .         .         .         .         .       g.864256
 ggcttgttacatttgtcatttaactgcagtgctattctttgaaagctgctatgtgtattt       c.*660

          .         .         .         .         .         .       g.864316
 tctctgaagtctgcattttactaaaatttacaacagtctgatgattgattgattactgtc       c.*720

          .         .         .         .         .         .       g.864376
 caggtacattttagaaaaagtgttcttcttccagtttgttttactaagcaaactttgagt       c.*780

          .         .         .         .         .         .       g.864436
 aaatcctttgtcctatattgaatccagtcccaaagtgttcaggtgagtttctctagttcc       c.*840

          .         .         .         .         .         .       g.864496
 ataaacaaaacatacatagtgggaactccctggtatgccatagagcacacaagaacccca       c.*900

          .         .         .         .         .         .       g.864556
 atattaatgctaacaattataccagtccattttgtttattctgtggaattgacttgacaa       c.*960

          .         .         .         .         .         .       g.864616
 agcatgaagatattcccagtgtctgtctgataatattttgcatctaagaatgggtttgac       c.*1020

          .         .         .         .         .         .       g.864676
 tcaagatcttgggttaccaagatgtcttaaatgttcagtaaatatctttcttacagtcca       c.*1080

          .         .         .         .         .         .       g.864736
 gtagcttagagcatgtttgctgattgatattacatttaaacttggggctacagcttgtta       c.*1140

          .         .         .         .         .         .       g.864796
 cctagaattttgagatactaagagaatgcaattttaaatgcccactggttttatttgttt       c.*1200

          .         .         .         .         .         .       g.864856
 tggagagagggtctcattctgtcacccaggctagagtacagtgggaacagtcatggctca       c.*1260

          .         .         .         .         .         .       g.864916
 ctgcagcttaagctcactgcctgggctcaagtgatcttactccagcctcccaagcagctg       c.*1320

          .         .         .         .         .         .       g.864976
 ggactacaccaccacaggtatgcaccaccatacctggctgatttttaaaattttttctag       c.*1380

          .         .         .         .         .         .       g.865036
 agatgaggtctcactatgttgcccagctggtctcatactcctcagttcacgcattcctcc       c.*1440

          .         .         .         .         .         .       g.865096
 cacctccacctcccaaactgctgggattacaggtgtgagccaccatgcccaacacccact       c.*1500

          .         .         .         .         .         .       g.865156
 gatctttaactctcacatgttgggcataagaagtcactatataattgttactggaaagca       c.*1560

          .         .         .         .         .         .       g.865216
 agacttaacgaacaattctgactatgaaaaatgtctctttcagtttgttctgtaaatatt       c.*1620

          .         .         .         .         .         .       g.865276
 tagaaaagtgacagctgtcaacctcagagtaactatttctaaaaatgtaaatatgtatta       c.*1680

          .         .         .         .         .         .       g.865336
 atccttgtatcttttatggtaattttgcatattgatatgaattatataaaattgtttaaa       c.*1740

          .         .         .         .         .         .       g.865396
 ataaaaggtgtccttgaattactgaccacccatagatgtctactgttaccaggttttaca       c.*1800

          .         .         .         .         .         .       g.865456
 atgcaaattttcactaatacctgggtttaatacagctcacatcactgaatgttacacatg       c.*1860

          .         .         .         .         .         .       g.865516
 agtttaaatgggtaatatacaggttttgttataataaagttactgattaaattagctttg       c.*1920

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Vacuolar protein sorting 13 homolog B (yeast) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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