The Pediatric Functional Neuroimaging Research Network welcomes you to the official website for the Cincinnati MR Imaging of Neurodevelopment (C-MIND) study. The Pediatric Functional Neuroimaging Research Network is a joint venture led by the Pediatric Neuroimaging Research Consortium at CCHMC in collaboration with the Laboratory of Neuroimaging (LONI), at University of Southern California, the Brain Mapping Center at UCLA, the Childrens Hospital of Pittsburgh, and University of Michigan. The Pediatric Functional Neuroimaging Research Network is supported by a contract with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and charged with creating standardized methods for recruiting, scanning, and processing brain imaging data from children from birth through adolecence.  This data set is now available through the C-MIND database and includes T1-W and T2-W 3D anatomical, BOLD-fMRI, DTI, and ASL imaging data across this age span, as well as a novel concurrent ASL/BOLD fMRI data set that allows exploration of new relationsships between brain stimulation and BOLD response. These methods have been documented in an online manual and a data dictionary, built into user-friendly image processing pipelines, and are now available to interested researchers throughout the United States and the world through this website.

In addition to developing these methods, a purpose of this neuroimaging research contract with NICHD has been to investigate brain development in children from infancy through adolescence. Members of the Network have begun to mine the C-MIND data set to look at developmental changes in white matter structure, gray matter structure, structural and functional connectivity, perfusion, neurovascular coupling and correlations between behavioral measures and brain developing. C-MIND allows exploration of developmental changes in brain anatomy, structural and functional connectivity, neurovascular coupling/reactivity and the interaction of brain development and cognitive changes during childhood. The C-MIND database includes imaging and behavioral data from over 200 typically developing children for a cross-sectional look at the differences in brain function throughout the age range. Additionally, C-MIND contains longitudinal imaging and behavioral data on 40 infants and toddlers (ages 0-3 years) as well as 30 children between the ages of 7-9 years.  Data acquisition is complete and all data is now available in the current release database. Imaging and behavioral data is not linked to identity or private health information for subjects in any way, so the data cannot be linked to individual subjects.  For most applications this means that use of the data is exempt from IRB approval or review.


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At Cincinnati Children’s Hospital Medical Center, we are committed to improving child health and advancing treatment procedures and outcomes for children today and in the future. We appreciate your interest in partnering with us in this endeavor.