{"id":31503,"date":"2020-05-12T15:54:55","date_gmt":"2020-05-12T15:54:55","guid":{"rendered":"https:\/\/research.cchmc.org\/lungimage\/?page_id=31503"},"modified":"2020-09-21T16:09:25","modified_gmt":"2020-09-21T16:09:25","slug":"submucosal-glands","status":"publish","type":"page","link":"https:\/\/research.cchmc.org\/lungimage\/?page_id=31503","title":{"rendered":"Submucosal Glands"},"content":{"rendered":"\t\t
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Cell Cards: Submucosal Glands<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tFigure 1: Structure and cellular niches of human submucosal glands.<\/b><\/span>\n

A<\/a>, B<\/a>, C<\/a>, D<\/a>, and F. I<\/b>mages of tissue isolated from a 4-year-old human lung. A)<\/a><\/b> H&E of a SMG opening into airway\u00a0surface epithelium (SE). Regions of the SMG are indicated: terminal ciliated duct (TCD)<\/span>, collecting duct (CD),\u00a0mucous tubules (MT) and the predominant cell types: mucous cells (MC), myoepithelial cells (MEC)<\/a> and\u00a0serous cells (SC).\nB-F.\u00a0<\/b>Immunofluorescent imaging of cell types within the terminal ciliated duct<\/span> (B<\/a>), mucous collecting duct\u00a0<\/span>(C<\/a>),\u00a0mucous tubule (D<\/a>), surface airway epithelium (<\/span>E-F<\/b>) and distal SMG acini (<\/span>E-G<\/b> ) showing expression of\u00a0<\/span>MUC5B in mucous cells, KRT14 and ACTA2 in myoepithelial cells <\/a>, and TUBA4A in ciliated cells.\u00a0<\/span>KRT5 is\u00a0<\/span>expressed in basal cells<\/a> of the surface airway and is co-expressed\u00a0with KRT14 in SMG myoepithelial cells <\/a>\u00a0<\/span>cells. \u00a0SOX2 is expressed in some epithelial cells in the surface airway\u00a0and\u00a0in the SMG. SOX9 is\u00a0<\/span>predominantly\u00a0expressed in SMG cells.\u00a0Insets are higher magnification images of boxed regions.\u00a0<\/span><\/span><\/b><\/span><\/p>\n\u00a0<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Second-Harmonic Generation<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u00a0<\/b>Visualization of a submucosal gland.<\/b> ACTA2\u00a0<\/span>stains myoepithelial cells<\/a>. <\/span>MUC5B stains the mucin made by goblet cells inside the gland surrounded by a collagen matrix detected by\u00a0<\/span>(SHG)<\/span><\/span><\/p>

Panel 1:<\/strong>\u00a02D image of a single Z-stack frames\u00a0\u00a0(Click to play video of rendered z stacks in larger popup window)<\/span><\/p>

Panel 2:<\/strong>\u00a03D surface rendering in Imaris\u00a0showing\u00a0the goblet cells using Imaris software.\u00a0(Click to play 3D video in larger popup window)<\/span><\/p>

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2D rendering of the Z-stacks showing the MUC5B expressing goblet cells (red) , ACTA2 expressing myoepithelial cells (green), and collagen from the second harmonics (white) confocal imaging.<\/h3>\n\t\t\t<\/div>\n\t\t\t\t\t\t
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3D surface rendering of the MUC5B expressing goblet cells (red), the ACTA expressing myoepithelial cells (green), and collagen from the second harmonics (white) confocal imaging.<\/h3>\n\t\t\t<\/div>\n\t\t\t\t\t\t
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\n\t\t\t\t\"2018-10-16_Grant\t\t\t<\/div>\n\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Terminal Ciliated Duct<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The opening of the terminal ciliated duct into the bronchiolar epithelium demarcates the location<\/span>\u00a0<\/b><\/span>of a submucosal gland (SMG).\u00a0These are present in a density of ~1 per mm<\/span>2<\/sup><\/span>\u00a0of airway surface epithelium.\u00a0\u00a0In humans, the greatest density can be found in the trachea and within the first four airway generations. In mouse, all SMGs are found lining the cricoid cartilage of the larynx and within the first few cartilaginous rings of the trachea. The length of the terminal duct is highly variable dependent on both the size and location of the gland. The function of this duct is expulsion of the products made by the gland into the airway. The basal and epithelial cells lining the terminal ciliated duct can appear as a monolayer, as well as have a pseudostratified appearance.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Cell Types<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tLumenal Epithelial<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Myoepithelial Cells<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A contractile cell found between secretory cells and basement membrane of the seromucus glands located in the submucosa of the upper trachea in the mouse. Each myoepithelial cell has long cytoplasmic processes that wrap around a secretory unit (acinus, or smalll cluster of cells with a central lumen). The contraction of the myoepithelial processes forces the secretory product from the secretory unit into its duct.\u00a0Wikipedia<\/a><\/span><\/td><\/tr><\/tbody><\/table>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Signature\nGenes<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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LungImage<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Cell Cards: Submucosal Glands X X X X I am a tooltip for a hotspot Figure 1: Structure and cellular niches of human submucosal glands. A, B, C, D, and F. Images of tissue isolated from a 4-year-old human lung. A) H&E of a SMG opening into airway\u00a0surface epithelium (SE). Regions of the SMG are […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-31503","page","type-page","status-publish","hentry"],"yoast_head":"\nSubmucosal Glands -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.cchmc.org\/lungimage\/?page_id=31503\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Submucosal Glands -\" \/>\n<meta property=\"og:description\" content=\"Cell Cards: Submucosal Glands X X X X I am a tooltip for a hotspot Figure 1: Structure and cellular niches of human submucosal glands. A, B, C, D, and F. Images of tissue isolated from a 4-year-old human lung. 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