ribosomal protein S7 (RPS7) - coding DNA reference sequence

(used for mutation description)

(last modified May 1, 2014)

This file was created to facilitate the description of sequence variants in the RPS7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering RPS7 transcript NM_001011.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.1046
               gcgctgtttccgcctcttgccttcggacgccggattttgacgtgct       c.-61

 .         .         .         .         .  | 02      .             g.1347
 ctcgcgagatttgggtctcttcctaagccggcgctcggcaag | ttctcccaggagaaagcc    c.-1

          .         .         .         .         .         .       g.1407
 ATGTTCAGTTCGAGCGCCAAGATCGTGAAGCCCAATGGCGAGAAGCCGGACGAGTTCGAG       c.60
 M  F  S  S  S  A  K  I  V  K  P  N  G  E  K  P  D  E  F  E         p.20

          .      | 03  .         .         .         .         .    g.1599
 TCCGGCATCTCCCAG | GCTCTTCTGGAGCTGGAGATGAACTCGGACCTCAAGGCTCAGCTC    c.120
 S  G  I  S  Q   | A  L  L  E  L  E  M  N  S  D  L  K  A  Q  L      p.40

          .         .        | 04.         .         .         .    g.2257
 AGGGAGCTGAATATTACGGCAGCTAAG | GAAATTGAAGTTGGTGGTGGTCGGAAAGCTATC    c.180
 R  E  L  N  I  T  A  A  K   | E  I  E  V  G  G  G  R  K  A  I      p.60

          .         .         .         .         .         .       g.2317
 ATAATCTTTGTTCCCGTTCCTCAACTGAAATCTTTCCAGAAAATCCAAGTCCGGCTAGTA       c.240
 I  I  F  V  P  V  P  Q  L  K  S  F  Q  K  I  Q  V  R  L  V         p.80

          .         .         .         .         .  | 05      .    g.3456
 CGCGAATTGGAGAAAAAGTTCAGTGGGAAGCATGTCGTCTTTATCGCTCAG | AGGAGAATT    c.300
 R  E  L  E  K  K  F  S  G  K  H  V  V  F  I  A  Q   | R  R  I      p.100

          .         .         .         .         .       | 06 .    g.5851
 CTGCCTAAGCCAACTCGAAAAAGCCGTACAAAAAATAAGCAAAAGCGTCCCAGGAG | CCGT    c.360
 L  P  K  P  T  R  K  S  R  T  K  N  K  Q  K  R  P  R  S  |  R      p.120

          .         .         .         .         .         .       g.5911
 ACTCTGACAGCTGTGCACGATGCCATCCTTGAGGACTTGGTCTTCCCAAGCGAAATTGTG       c.420
 T  L  T  A  V  H  D  A  I  L  E  D  L  V  F  P  S  E  I  V         p.140

          .         .         .         .         .         .       g.5971
 GGCAAGAGAATCCGCGTCAAACTAGATGGCAGCCGGCTCATAAAGGTTCATTTGGACAAA       c.480
 G  K  R  I  R  V  K  L  D  G  S  R  L  I  K  V  H  L  D  K         p.160

          .         .        | 07.         .         .         .    g.6575
 GCACAGCAGAACAATGTGGAACACAAG | GTTGAAACTTTTTCTGGTGTCTATAAGAAGCTC    c.540
 A  Q  Q  N  N  V  E  H  K   | V  E  T  F  S  G  V  Y  K  K  L      p.180

          .         .         .         .                           g.6620
 ACGGGCAAGGATGTTAATTTTGAATTCCCAGAGTTTCAATTGTAA                      c.585
 T  G  K  D  V  N  F  E  F  P  E  F  Q  L  X                        p.194

          .         .         .                                     g.6657
 acaaaaatgactaaataaaaagtatatattcacagta                              c.*37

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Ribosomal protein S7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.