LungGENS

Please acknowledge Lung at a glance, LGEA web portal and LungGENS in your publications by citing the following references:

Du Y, Ouyang W, Kitzmiller JA, Guo M, Zhao S, Whitsett JA, Xu Y. Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance. Am J Respir Cell Mol Biol. 2021 Jan;64(1):146-149.
Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y. Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development. Thorax 2017;72(5):481-84.
Du Y, Guo M, Whitsett JA, Xu Y. 'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung. Thorax. 2015;70(11):1092-1094.

Research Interests

The main research interest of Dr. Xu's group is to apply bioinformatics and systems biology approaches to biological and clinical data to gain better understanding of molecular mechanisms underlying lung development and pathogenesis. The current research focus include the identification of gene signatures, regulatory networks and biological pathways controlling lung maturation and surfactant and map the lung transcriptome at single cell level. Dr. Xu has considerable experience and expertise on gene expression profiling and transcriptional network studies and has set up the infrastructure and analytic pipelines in Pulmonary Biology Microarray-Bioinformatics Core for various Bioinformatics applications including the analysis of lung single cell transcriptome, mRNA microarray, miRNA array, ChIP-seq, RNA-seq, gene signature identification and pathway mapping and transcriptional network development. Her research goal is to integrate data from new computational methods and experimental approaches in a synergistic way to gain better understanding of molecular mechanisms underlying lung development and pathogenesis.

Research Members

Yan Xu, Ph.D.

Professor of Pediatrics, Division of Pulmonary Biology and Biomedical Informatics, Perinatal Institute, Cincinnati Children's Hospital Medical Center,University of Cincinnati School of Medicine

Phone 513-636-8921
Email yan.xu@cchmc.org
Location T11.605
Biography CCHMC Link

Minzhe Guo, Ph.D.

Assistant Professor of Pediatrics, Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center,University of Cincinnati School of Medicine

Phone 513-517-0076
Location T11.607
Email minzhe.guo@cchmc.org