Welcome to LungGENS!   (For the best experience, please use the following browsers, including Google Chrome, or Apple Safari . )



Please acknowledge LGEA web portal and LungGENS in your publications by citing the following two references:
  • Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y. Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development. Thorax 2017;72(5):481-84.
  • Du Y, Guo M, Whitsett JA, Xu Y. 'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung. Thorax. 2015;70(11):1092-1094.



Research Interests

The main research interest of Dr. Xu's group is to apply bioinformatics and systems biology approaches to biological and clinical data to gain better understanding of molecular mechanisms underlying lung development and pathogenesis. The current research focus include the identification of gene signatures, regulatory networks and biological pathways controlling lung maturation and surfactant and map the lung transcriptome at single cell level. Dr. Xu has considerable experience and expertise on gene expression profiling and transcriptional network studies and has set up the infrastructure and analytic pipelines in Pulmonary Biology Microarray-Bioinformatics Core for various Bioinformatics applications including the analysis of lung single cell transcriptome, mRNA microarray, miRNA array, ChIP-seq, RNA-seq, gene signature identification and pathway mapping and transcriptional network development. Her research goal is to integrate data from new computational methods and experimental approaches in a synergistic way to gain better understanding of molecular mechanisms underlying lung development and pathogenesis.



Research Members

Yan Xu, PhD

Professor of Pediatrics, Division of Pulmonary Biology and Biomedical Informatics, Perinatal Institute, Cincinnati Children's Hospital Medical Center,University of Cincinnati School of Medicine

Phone 513-636-8921
Email yan.xu@cchmc.org
Biography CCHMC Link


Minzhe Guo, PhD

RESEARCH FELLOW

Phone 513-636-1355
Location T11.507
Email minzhe.guo@cchmc.org


Yina Du

Data Analyst, Application Developer, Database Administrator

Phone 513-636-0535
Location T11.507
Email Yina.Du@cchmc.org


Parvathi Sudha

Data Analyst

Phone 513-636-0535
Location T11.507
Email ParvathiSudha.KanhangadKakkanath@cchmc.org


Shuyang Zhao

Data Analyst

Phone
Location T11.525
Email Shuyang.Zhao@cchmc.org


Weichen Ouyang

Visiting research scientist

Phone
Location T11.525
Email Weichen.Ouyang@cchmc.org


Andrew Wagner

CS Student CO-OP

Phone
Location T11.525
Email Andrew.Wagner@cchmc.org



Previous Research Members

Sandipto Banerjee

Application Developer, Database Administrator

Erik Bao

SURF summer research student

Liya Huo

Data Analyst

Benjamin Vidourek

BME Student CO-OP

Kyle Melling

BME Student CO-OP

Dakota Lipps

BME Student CO-OP

Ruochen Tang

CS Student CO-OP

Yuan Cheng

CS Student CO-OP