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News and updates
Our recent research activities related to SARS-CoV-2
  • Sungnak W, et al, and Network HCALB. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med 26: 681-687, 2020. Drs. Jeffrey Whitsett, Xin Sun, Yan Xu and Minzhe Guo from LungMAP are involved in this study, investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNAseq data from healthy human donors. Access these data at www.covid19cellatlas.org
  • Muus C, et al. Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells. bioRxiv 2020.
  • Wang A, et al. Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection. Elife. 2020 Nov 9;9:e62522. Elife, PubMed
New web development
  • Check out LGEA (LungMAP phase 2) for more datasets from normal and disease lungs.
  • LGEA provides query links to access DESCARTES (Human Gene Expression During Development) website in LungDTC panel.
New publication
  • Du Y, Ouyang W, Kitzmiller JA, Guo M, Zhao S, Jeffrey A Whitsett JA, Xu Y. Lung Gene Expression Analysis (LGEA) Web Portal v3: Lung at a Glance. AJRCMB. 2021. AJRCMB PubMed bioRxiv
  • Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y. Single Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. Am J Respir Crit Care Med. 2020 Jun 30. AJRCCM PubMed
  • Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell Stem Cell. 2020 Apr 2;26(4):482-502. PubMed PubMed Central
  • J. P. Bridges, P. Sudha, D. Lipps, M. Guo, Y. Du, K. Brown, A. Filuta, Joseph Kitzmiller, C. Stockman, X. Chen, Alan H. Jobe, J. Whitsett, M. Weirauch, and Y. Xu. Glucocorticoid Dependent Mesenchymal Cell Differentiation is Required for Perinatal Lung Morphogenesis and Lung Function. Am J Physiol Lung Cell Mol Physiol. 2020. AJP-Lung
  • Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, Bridges J, Lewkowich I, Xu Y, Ahlfeld S, Zacharias W, Alenghat T, and Deshmukh H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity 52: 275-294 e279, 2020.PubMed
  • Guo M, Du Y, Gokey JJ, Ray S, Bell SM, Adam M, Sudha P, Perl AK, Deshmukh H, Potter SS, Whitsett JA, Xu Y. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nat Commun. 2019 Jan 3;10(1):37. PubMed; PubMed Central

Cite LungGENS, LGEA web portal and Lung at a glance
1. Du Y, Guo M, Whitsett JA, Xu Y. “LungGENS”: a web-based tool for mapping single-cell gene expression in the developing lung. Thorax. 2015;70(11):1092-1094.
2. Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y. Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development. Thorax 2017;72(5):481-84.
3. Du Y, Ouyang W, Kitzmiller JA, Guo M, Zhao S, Whitsett JA, Xu Y. Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance. Am J Respir Cell Mol Biol. 2021 Jan;64(1):146-149.

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