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   Mersha Lab @CCHMC

http://www.med.uc.edu/
http://www.cincinnatichildrens.org/about/uc-affiliation/pediatrics/default/
 
Publications
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Kovacic MB, Myers JM, Wang N, Martin LJ, Lindsey M, Ericksen MB, He H, Patterson TL, Baye TM, Torgerson D, Roth LA, Gupta J, Sivaprasad U, Gibson AM, Tsoras AM, Hu D, Eng C, Chapela R, Rodríguez-Santana JR, Rodríguez-Cintrón W, Avila PC, Beckman K, Seibold MA, Gignoux C, Musaad SM, Chen W, Burchard EG, Hershey GK. Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences. PLoS One. 2011 Aug 30; 6(8):e23714.
Baye TM. Inter-chromosomal variation in the pattern of human population genetic structure. Human Genomics. 2011;5(4):220–240.
Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp M, Eissa NT, Borish L, Khurana Hershey GK. Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children. PLoS One. 2011 Feb 28;6(2):e16522.
Baye TM, Abebe T, Wilke RA. Genotype-environment interactions and their translational implications. Personalized Medicine. 2011;8:59-70.
Baye TM & Wilke RA. Mapping genes that predict treatment outcome in admixed populations. The Pharmacogenomics Journal. 2010 Oct; 10(6): 465-77. 
Baye TM, Martin LJ, Khurana Hershey GK. Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol. 2010 Sep;126(3):425-36.
Gawrieh S, Baye TM, Carless M, Wallace J, Komorowski R, Kleiner DE, Andris D, Makladi B, Cole R, Charlton M, Curran J, Dyer TD, Charlesworth J, Wilke R, Blangero J, Kissebah AH, Olivier M. Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease. Obes Surg. 2010 Dec;20(12):1698-709.
Zhang Y, Smith EM, Baye TM, Zelembaba M, James R, Kissebah AH, Martin L, and Olivier M. Sequence variants in HTR5A affect triglyceride levels in obese individuals. Physiological Genomics. 2010; 42:168-176.
Smith EM, Zhang Y, Baye TM, Gawrieh S, Cole R, Blangero J, Carless MA, Curran JE, Dyer TD, Abraham LJ, Moses EK, Kissebah AH, Martin LJ, Olivier M. INSIG1 influences obesity-related hypertriglyceridemia in humans. J Lipid Res. 2010 Apr;51(4):701-8.
Baye TM, Wilke RA, Olivier M. Genomic and geographic distribution of private SNPs and pathways in human populations. Per Med. 2009 Nov 1;6(6):623-641.
Zhang Y, Sonnenberg GE, Baye TM, Littrell J, Gunnell J, DeLaForest A, MacKinney E, Hillard CJ, Kissebah AH, Olivier M, Wilke RA. Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent. Pharmacogenomics. 2009 Dec;10(12):1929-39.
Baye TM, Hemant K. Tiwari, and David B. Allison. Database mining for selection of SNP markers useful in admixture mapping. BioData Mining. 2008; 2:1(1-8).
Shriner D, Baye TM, Padilla MA, Zhang S, Vaughan LK, Loraine AE. Commonality of functional annotation: a method for prioritization of candidate genes from genome-wide linkage studies.Nucleic Acids Res. e26, 2008.
Baye TM, Zhang S, Smith E, Gunnell J, Hillard CJ, McCarty D, Myklebust J, James R, Kissebah AH, Olivier M and Wilke RA. Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. Pharmacogenomics. 2008; 9(11):1647-1656.
Tesfaye M. Baye, Rodney T. Perry, Howard W. Wiener, Zuomin Chen, Lindy Harrell, Rodney Go. Candidate gene discovery procedure after follow-up confirmatory analyses of candidate regions of interests for Alzheimer’s disease in the NIMH sibling dataset.Dis Markers. 2007; 24:293-309.

Publications

View PubMed Publications


  1. Gautam G, Afanador Y, Abebe T, López JE, Mersha TB (2019). Genome-wide analysis revealed sex-specific gene expression in asthmatics. Human Molecular Genetics, ddz074. In press.

  2. Ghosh D, Bernstein JA, Hershey GKK, Rothenberg ME, Mersha TB (2019). Leveraging multilayered "omics" data for atopic dermatitis: a road map to precision medicine. Front Immunol. 12;9:2727. PMID: 30631320.

  3. Ding L, Li D, Wathen M, Altaye M, Mersha TB (2018). African ancestry is associated with cluster-based childhood asthma subphenotypes. BMC Med Genomics. 11(1):51. PMID: 29855310.

  4. Ghandikota S, Hershey GKK, Mersha TB (2018). GENEASE: Real time bioinformatics tool for multi-omics and disease ontology exploration, analysis and visualization. Bioinformatics. 34(18):3160-3168. PMID: 29590301.

  5. Kim Y, Hao J, Gautam Y, Mersha TB, Kang M (2018). DiffGRN: Differential gene regulatory network analysis. International Journal of Data Mining and Bioinformatics 20 (4): 362-379.

  6. Harding K, Biks GA, Adefris M, Loehr J, Gashaye KT, Tilahun B, Volynski M, Garg S, Abebaw Z, Dessie K, Mersha TB (2018). A mobile health model supporting Ethiopia’s eHealth strategy. Digital Medicine 4 (2): 54-65.

  7. Barnes JC, Liu H, Tanksley P, Motz R, Mersha, TB (2018). Every contact leaves a trace: contact with the criminal justice system, life outcomes, and the intersection with genetics. Current Opinion in Psychology 27:82-87. PMID: 30347286.

  8. Gautam, Y, Altaye, M, Xie, C., Mersha TB (2017). AdmixPower: Statistical power and sample size estimation for mapping genetic loci in admixed populations. Genetics (Genetics Society of America). 207: 873–882. PMID: 28951529.

  9. Johansson E, Biagini Myers JM, Martin LJ, He H, Pilipenko V, Mersha TB, Weirauch M, Salomonis N, Ryan P, LeMasters GK, Bernstein DI, Lockey J, Khurana Hershey GK (2017). KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis. J Allergy Clin Immunol. 140(2):595-598. PMID: 28238750.

  10. Mersha, TB, Cassidy C., Johansson E., Hershey GKK (2017). Shared genetic etiology and ancestry variations between asthma and major complex diseases. Journal of Allergy and Clinical Immunology Vol. 139, Issue 2, Supplement [AB84]. DOI: http://dx.doi.org.

  11. Harding K, Mersha TB, Pham PT, Waterman AD, Webb FA, Vassalotti JA, Nicholas SB (2017). Health disparities in kidney transplantation for african americans. Am J Nephrol. 2017;46(2):165-175. PMID: 28787713.

  12. Maglo KN, Mersha TB, Martin LJ (2106). Population Genomics and the Statistical Values of Race: An Interdisciplinary Perspective on the Biological Classification of Human Populations and Implications for Clinical Genetic Epidemiological Research. Front Genet. 7:22. PMID: 26925096.

  13. Gupta J, Johansson E, Bernstein JA, Chakraborty R, Hershey GKK, Rothenberg ME, Mersha TB. Resolving the etiology of atopic disorders by genetic analysis of racial ancestry. J Allergy Clin Immunol. 2016 Sep; 138(3):676-99. PMID: 27297995

  14. Mersha TB. Mapping asthma-associated variants in admixed populations. Front. Genet. 6:292. doi: 10.3389/fgene.2015.00292

  15. Ghosh D, Ding L, Sivaprasad U, Geh E, Biagini Myers J, Bernstein JA, Khurana Hershey GK, Mersha TB. Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways. PLoS One. 2015 Dec 30;10(12):e0144316. PMID: 26717000

  16. Mersha TB, Martin LJ, Biagini Myers JM, Kovacic MB, Lindsey M, Chen W, Hershey GKK. Genomic architecture of asthma differs by sex. Genomics. 106(1):15-22. PMID: 25817197

  17. Mersha TB, Abebe T. Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities. Human Genomics 9:1. PMID: 25563503

  18. Butsch Kovacic M, Martin LJ, Biagini Myers JM, He H, Lindsey M, Mersha TB, Khurana Hershey GKK. Genetic approach identifies distinct asthma pathways in overweight vs normal weight children. Allergy. 70(8):1028-32. PMID: 26009928

  19. Sadhasivam S, Zhang X, Chidambaran V, Mavi J, Pilipenko V, Mersha TB, Meller J, Kaufman K, Martin L, McAuliffe J. Novel Associations between FAAH Genetic Variants and Postoperative Central Opioid related Adverse Effects. Pharmacogenomics J. 15(5):436-42. PMCID: PMC4492912

  20. Mersha TB, Ding L, He H, Alexander ES, Zhang X, Kurowski BG, Pilipenko V, Kottyan L, Martin LJ, Fardo DW. Impact of Population Stratification on Family-Based Association in an Admixed Population. Int J Genomics. 2015:501617. PMID: 26064873

  21. Biagini Myers JM, Martin LJ, Mersha TB, Bernstein DI, LeMasters GK, Khurana Herhsey GK. Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma. J Allergy Clin Immunol. [Epub ahead of print]. PMID: 24831437

  22. Pilipenko V, Kurowski B, Alexander ES, Ding L, Mersha TB, Fardo D, Martin LJ. Using Mendelian inheritance errors as quality control criteria in whole genome sequencing dataset. BMC Proceedings 2014, 8:S21

  23. Ding L, Kurowski BG, He H, Alexander ES, Mersha TB, Fardo DW, Zhang X, Pilipenko V, Kottyan L, Martin LJ. Modeling of Multivariate Longitudinal Phenotypes in Family Genetic Studies with Bayesian Multiplicity Adjustment. BMC Proceedings 2014, 8:S69

  24. Fardo DW, Zhang X, Ding L, He H, Kurowski B, Alexander E, Mersha TB, Pilipenko V, Kottyan L and Martin LJ. On Family-based Genome-wide Association Studies with Large Pedigrees: Observations and Recommendations. BMC Proceedings 2014, 8(Suppl 1):S26.

  25. Ding L, Abebe T, Beyene J, Wilke RA, Goldberg A, Woo JG, Martin LJ, Rothenberg ME, Rao M, Hershey GK, Chakraborty R, Mersha TB. Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations. Hum Genomics. 2013 Jul 5;7:16.

  26. Bienengraeber M, Pellitteri-Hahn M, Hirata N, Baye TM, Bosnjak ZJ, Olivier M. Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia. Physiol Genomics. 2013 Mar 1;45(5):163-70.

  27. Amirisetty S, Hershey GK, Baye TM. AncestrySNPminer: A bioinformatics tool to retrieve and develop ancestry informative SNP panels. Genomics. 2012 Jul;100(1):57-63.

  28. Feng Q, Wilke RA, Baye TM. Individualized risk for statin-induced myopathy-current knowledge, emerging challenges, and potential solutions. Pharamcogenomics 2012 Apr;13(5):579-94.

  29. Ding L, Wiener H, Abebe T, Altaye M, Go RC, Kercsmar C, Grabowski G, Martin LJ, Hershey GK, Chakorborty R, Baye TM. Comparison of measures of marker informativeness for ancestry and admixture mapping. BMC Genomics. 2011 Dec 20;12(1): 622.

  30. Baye TM, He H, Ding L, Kurowski BG, Zhang X, Martin LJ. Population structure analysis using rare and common functional variants. BMC Proceedings 2011 Nov 29, 5: S8.

  31. Ding L, Baye TM, He H, Zhang X, Kurowski BG and Martin LJ. Detection of associations with rare and common SNPs for quantitative traits: a nonparametric Bayes based approach. BMC Proceedings 2011 Nov 29, 5: S10.

  32. Zhang X, He H, Ding L, Baye TM, Kurowski B, Martin LJ. Family and population based data identify different rare causal variants. BMC Proceedings 2011 Nov 29, 5: S36.

  33. He H, Ding L, Zhang X, Baye TM, Kurowski BG, Martin LJ. Effect of population stratification analysis on false positive rates for common and rare variants. BMC Proceedings 2011 Nov 29, 5: S116.

  34. Kovacic MB, Myers JM, Wang N, Martin LJ, Lindsey M, Ericksen MB, He H, Patterson TL, Baye TM, Torgerson D, Roth LA, Gupta J, Sivaprasad U, Gibson AM, Tsoras AM, Hu D, Eng C, Chapela R, Rodríguez-Santana JR, Rodríguez-Cintrón W, Avila PC, Beckman K, Seibold MA, Gignoux C, Musaad SM, Chen W, Burchard EG, Hershey GK. Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.. PLoS One. 2011 Aug 30; 6(8):e23714.

  35. Baye TM. Inter-chromosomal variation in the pattern of human population genetic structure. Human Genomics. 2011;5(4):220–240.

  36. Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp M, Eissa NT, Borish L, Khurana Hershey GK. Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children. PLoS One. 2011 Feb 28;6(2):e16522.

  37. Baye TM, Abebe T, Wilke RA. Genotype-environment interactions and their translational implications. Personalized Medicine. 2011;8:59-70.

  38. Baye TM & Wilke RA. Mapping genes that predict treatment outcome in admixed populations. The Pharmacogenomics Journal. 2010 Oct; 10(6): 465-77. 

  39. Baye TM, Martin LJ, Khurana Hershey GK. Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol. 2010 Sep;126(3):425-36.

  40. Gawrieh S, Baye TM, Carless M, Wallace J, Komorowski R, Kleiner DE, Andris D, Makladi B, Cole R, Charlton M, Curran J, Dyer TD, Charlesworth J, Wilke R, Blangero J, Kissebah AH, Olivier M. Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease. Obes Surg. 2010 Dec;20(12):1698-709.

  41. Zhang Y, Smith EM, Baye TM, Zelembaba M, James R, Kissebah AH, Martin L, and Olivier M. Sequence variants in HTR5A affect triglyceride levels in obese individuals. Physiological Genomics. 2010; 42:168-176.

  42. Smith EM, Zhang Y, Baye TM, Gawrieh S, Cole R, Blangero J, Carless MA, Curran JE, Dyer TD, Abraham LJ, Moses EK, Kissebah AH, Martin LJ, Olivier M. INSIG1 influences obesity-related hypertriglyceridemia in humans. J Lipid Res. 2010 Apr;51(4):701-8.

  43. Baye TM, Wilke RA, Olivier M. Genomic and geographic distribution of private SNPs and pathways in human populations. Per Med. 2009 Nov 1;6(6):623-641.

  44. Zhang Y, Sonnenberg GE, Baye TM, Littrell J, Gunnell J, DeLaForest A, MacKinney E, Hillard CJ, Kissebah AH, Olivier M, Wilke RA. Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent. Pharmacogenomics. 2009 Dec;10(12):1929-39.

  45. Baye TM, Hemant K. Tiwari, and David B. Allison. Database mining for selection of SNP markers useful in admixture mapping. BMC BioData Mining. 2008; 2:1(1-8).

  46. Shriner D, Baye TM, Padilla MA, Zhang S, Vaughan LK, Loraine AE. Commonality of functional annotation: a method for prioritization of candidate genes from genome-wide linkage studies.Nucleic Acids Res. e26, 2008.

  47. Baye TM, Zhang S, Smith E, Gunnell J, Hillard CJ, McCarty D, Myklebust J, James R, Kissebah AH, Olivier M and Wilke RA. Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. Pharmacogenomics. 2008; 9(11):1647-1656.

  48. Tesfaye M. Baye, Rodney T. Perry, Howard W. Wiener, Zuomin Chen, Lindy Harrell, Rodney Go. Candidate gene discovery procedure after follow-up confirmatory analyses of candidate regions of interests for Alzheimer’s disease in the NIMH sibling dataset.Dis Markers. 2007; 24:293-309.



Information

Tesfaye B.Mersha Ph.D.
Assistant Professor
Cincinnati Children's Hospital Medical Center
Department of Pediatrics
University of Cincinnati
Phone: 513-803-2766
Fax: 513-636-1657
E-mail: tesfaye.mersha@cchmc.org
Page: 
http://homepages.uc.edu/~mershate/mershaslab/Home.html


Information


Tesfaye B. Mersha, PhD

Associate Professor
Cincinnati Children's Hospital Medical Center
Department of Pediatrics
University of Cincinnati
3333 Burnet Avenue, MLC 7037
Cincinnati,OH 45229-3026

Phone: 513-803-2766
Fax: 513-636-1657

E-mail: tesfaye.mersha@cchmc.org