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Mersha Lab @CCHMC

http://www.med.uc.edu/
http://www.cincinnatichildrens.org/about/uc-affiliation/pediatrics/default/
 
Research Interests Key words: Human Genetics/Genomics, Statistical Genomics, Human Ancestry Variation, Ancestry Informative Markers, Expression Profiling, Allergy/Asthma.

Research Interests


  1. Bullet    Key words: Human Genetics/Genomics, Statistical Genomics, Human Ancestry Variation, Ancestry Informative Markers, Expression Profiling, Allergy/Asthma.


Research Summary The Mersha’s Laboratory is in the Division of Asthma Research at the Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine. Our research involves the application of statistical analysis methods to studies of human populations in order to elucidate genetic and environmental contributions to complex diseases, particularly asthma and asthma-related allergic disorders. Currently, we are working on three projects: 1) the study of admixture mapping in African-American asthmatic population. The goal of this project is to develop and evaluate an efficient approach to localize asthma liability genes in an admixed African American population; 2) comprehensive expression profiling study to identify genes and regulatory networks that impact the atopic dermatitis (AD) phenotype; and 3) developing web applications/online tools to facilitate data mining as applied to genomic databases. As part of our research contribution, we recently developed a novel web-based tool, AncestrySNPminer, which helps to develop panel of genome-wide ancestry informative markers (AIMs) to be used for ancestry inference, admixture mapping, and structured association testing in individuals with mixed ancestry.

Research Summary


The Mersha’s Laboratory is in the Division of Asthma Research at the Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine. Our research involves the application of statistical analysis methods to studies of human populations in order to elucidate genetic and environmental contributions to complex diseases, particularly asthma and asthma-related allergic disorders. Currently, we are working on three projects: 1) the study of admixture mapping in African-American asthmatic population. The goal of this project is to develop and evaluate an efficient approach to localize asthma liability genes in an admixed African American population; 2) comprehensive expression profiling study to identify genes and regulatory networks that impact the atopic dermatitis (AD) phenotype; and 3) developing web applications/online tools to facilitate data mining as applied to genomic databases.


As part of our research contribution, we recently developed a novel web-based tool, AncestrySNPminer, which helps to develop panel of genome-wide ancestry informative markers (AIMs) to be used for ancestry inference, admixture mapping, and structured association testing in individuals with mixed ancestry.


 Information  Tesfaye B.Mersha Ph.D. Assistant Professor
Cincinnati Children's Hospital Medical Center
Department of Pediatrics
University of Cincinnati
Phone: 513-803-2766
Fax: 513-636-1657 E-mail: tesfaye.mersha@cchmc.org Page: http://homepages.uc.edu/~mershate/mershaslab/Home.html


Information


Tesfaye B. Mersha, PhD

Professor
Cincinnati Children's Hospital Medical Center
Department of Pediatrics
University of Cincinnati
3333 Burnet Avenue, MLC 7037
Cincinnati,OH 45229-3026
Phone: 513-803-2766
Fax: 513-636-1657

E-mail: tesfaye.mersha@cchmc.org