Single cell multiomics identifies cells and genetic networks underlying alveolar capillary dysplasia

Minzhe Guo, Kathryn A. Wikenheiser-Brokamp, Joseph A. Kitzmiller, Guolun Wang, Allen Wang, Sebastian Preissl, Justyna A. Karolak, David B. Frank, William J. Zacharias, Xin Sun, Yan Xu, Mingxia Gu, Pawel Stankiewicz, Vladimir V. Kalinichenko, Jennifer A. Wambach, Jeffery A. Whitsett

SUMMARY

Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) is a lethal developmental disorder of lung morphogenesis caused by insufficiency of FOXF1 transcription factor function. In this study, we used single nucleus RNA and ATAC sequencing, immunofluorescence confocal microscopy, and RNA in situ hybridization to identify cell types and molecular networks influenced by FOXF1 in ACDMPV lungs.


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