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  1. Our recent research activities related to SARS-CoV-2 Muus C, et al. Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells. bioRxiv 2020.
  2. Our recent research activities related to SARS-CoV-2 Wang A, et al. Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection. bioRxiv2020.
  3. Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, and Xu Y. Identification of the lymphangioleiomyomatosis cell and its uterine origin. Am J Respir Crit Care Med. In press. 2020.
  4. J. P. Bridges, P. Sudha, D. Lipps, M. Guo, Y. Du, K. Brown, A. Filuta, Joseph Kitzmiller, C. Stockman, X. Chen, Alan H. Jobe, J. Whitsett, M. Weirauch, and Y. Xu. Glucocorticoid Dependent Mesenchymal Cell Differentiation is Required for Perinatal Lung Morphogenesis and Lung Function. Am J Physiol Lung Cell Mol Physiol. In press. 2020.
  5. Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, Bridges J, Lewkowich I, Xu Y, Ahlfeld S, Zacharias W, Alenghat T, and Deshmukh H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity 52: 275-294 e279, 2020
  6. Du Y, Clair GC, Al Alam D, Danopoulos S, Schnell D, Kitzmiller JA, Misra RS, Bhattacharya S, Warburton D, Mariani TJ, Pryhuber GS, Whitsett JA, Ansong C, and Xu Y. Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. Am J Physiol Lung Cell Mol Physiol, 2019. [Pubmed]
  7. Guo M, Du Y, Gokey JJ, Ray S, Bell SM, Adam M, Sudha P, Perl AK, Deshmukh H, Potter SS, Whitsett JA, and Xu Y. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nat Commun 10: 37, 2019.(1-3). [Pubmed]
  8. Ren X, Ustiyan V, Guo M, Wang G, Bolte C, Zhang Y, Xu Y, Whitsett JA, Kalin TV, and Kalinichenko VV. Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT(+) Endothelial Progenitor Cells. Am J Respir Crit Care Med, 2019.[Pubmed]
  9. Schmidt AF, Kannan PS, Bridges JP, Filuta A, Lipps D, Kemp M, Miller LA, Kallapur SG, Xu Y, Whitsett JA, and Jobe AH. Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques. Sci Rep 9: 9039, 2019. [Pubmed]
  10. Whitsett JA, Kalin TV, Xu Y, and Kalinichenko VV. Building and Regenerating the Lung Cell by Cell. Physiol Rev 99: 513-554, 2019. [Pubmed]
  11. Ljungberg MC, Sadi M, Wang Y, Aronow BJ, Xu Y, Kao RJ, Liu Y, Gaddis N, Ardini-Poleske ME, Umrod T, Ambalavanan N, Nicola T, Kaminski N, Ahangari F, Sontag R, Corley RA, Ansong C, and Carson JP. Spatial distribution of marker gene activity in the mouse lung during alveolarization. Data Brief 22: 365-372, 2019. [Pubmed]
  12. Prasse A, Binder H, Schupp JC, Kayser G, Bargagli E, Jaeger B, Hess M, Rittinghausen S, Vuga L, Lynn H, Violette S, Jung B, Quast K, Vanaudenaerde B, Xu Y, Hohlfeld JM, Krug N, Herazo-Maya JD, Rottoli P, Wuyts WA, and Kaminski N. BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med 199: 622-630, 2019.[Pubmed]
  13. Guo M and Xu Y. Single-Cell Transcriptome Analysis Using SINCERA Pipeline. Methods Mol Biol 1751: 209-222, 2018. [Pubmed]
  14. Kyle JE, Clair G, Bandyopadhyay G, Misra RS, Zink EM, Bloodsworth KJ, Shukla AK, Du Y, Lillis J, Myers JR, Ashton J, Bushnell T, Cochran M, Deutsch G, Baker ES, Carson JP, Mariani TJ, Xu Y, Whitsett JA, Pryhuber G, Ansong C. Cell type-resolved human lung lipidome reveals cellular cooperation in lung function. Sci Rep. 2018 Sep 7;8(1):13455. [Pubmed]
  15. Bandyopadhyay G, Huyck HL, Misra RS, Bhattacharya S, Wang Q, Mereness J, Lillis J, Myers JR, Ashton J, Bushnell T, Cochran M, Holden-Wiltse J, Katzman P, Deutsch G, Whitsett JA, Xu Y, Mariani TJ, and Pryhuber GS. Dissociation, cellular isolation, and initial molecular characterization of neonatal and pediatric human lung tissues. Am J Physiol Lung Cell Mol Physiol 315: L576-L583, 2018.[Pubmed]
  16. Gokey JJ, Snowball J, Sridharan A, Speth JP, Black KE, Hariri LP, Perl AT, Xu Y, and Whitsett JA. MEG3 is increased in idiopathic pulmonary fibrosis and regulates epithelial cell differentiation. JCI Insight 3, 2018.[Pubmed]
  17. Gokey JJ, Sridharan A, Xu Y, Green J, Carraro G, Stripp BR, Perl AT, and Whitsett JA. Active epithelial Hippo signaling in idiopathic pulmonary fibrosis. JCI Insight 3, 2018.[Pubmed]
  18. Ustiyan V, Bolte C, Zhang Y, Han L, Xu Y, Yutzey KE, Zorn AM, Kalin TV, Shannon JM, and Kalinichenko VV. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Dev Biol 443: 50-63, 2018.[Pubmed]
  19. Black M, Milewski D, Le T, Ren X, Xu Y, Kalinichenko VV, and Kalin TV. FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Cell Rep 23: 442-458, 2018.[Pubmed]
  20. LEGA has been selected to be featured in February issue, Editors' Picks section of Biomedical Advances. [Link]