# Reports: 21,560,354
Data Range: 2004q1 - 2024q2
AERS
Mine
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Querying AERSMine - Basic Workflow
Drugs
Indications
Adverse Events
Demographics
Options
Analyze Data
Explore Analysis
Edit
Details
Filters
Analysis Console
Ranking
Save and Load Analyses
Save Analysis
Create a sample query
Run Analysis
Save Analysis
Add title and description
Saving the generated file
Load Analysis
Load an Analysis
Choose a file
Select a saved analysis
A loaded analysis
How To: Sample Queries
Query for a single drug, indication or adverse event
Search adalimumab AEs
View and Change Filters
Select Known AEs
Visualize
Analyze Multiple-Cohorts
Search adalimumab AEs without confounding drugs
Search adalimumab + methotrexate without steroids
Include rheumatoid arthritis and exclude cancer patients
Analyze differential risk profiles across adults and elderly (males + females)
View and Change Filters
Visualize
Worked Examples
Lithium
Logical Workflow
Identify AEs correlated with lithium use
Exclude drugs known to interact with lithium
Identify Rx that may mitigate lithium toxicities
Comparative analysis of therapeutic effects
Lithium + ARBs
Anti-TNFs
Logical Workflow
Create cohorts
Analyze overall and between-group risks
Visualize selected AEs
NSAIDs - Example 1
Create cohorts
Comparative analysis of differential effects
Increased risk of AEs due to coxibs use
NSAIDs - Example 2
Baseline non-aspirin NSAIDs risks
Chronic use of NSAIDs
NSAIDS and combinatorial Rx
NSAIDs and specific ARBs
Supplementary Files
Lithium
Anti-TNFs
NSAIDs - Example 1
NSAIDs - Example 2
Supplementary Tables
AERS Data distribution
Additional Supplementary Files
AERS
Mine
: Sample Queries
1. Query for a single drug, indication or adverse event
a. Identify high-frequency and high-risk events associated/reported with the use of adalimumab
Search adalimumab AEs
Search reports with adalimumab as one of the reported drugs.
To see adalimumab-correlated adverse events, select Adverse Events from Options and click Run Analysis.
View the absolute counts for adalimumab-correlated adverse events. Only the top 50 events are shown. To view the complete list of events, click Ranking Controls in Explore Analysis and click All in Rank By, alternatively select Download on any of the matrix subtypes.
View and Change Filters
Select Analysis Filters to modify AE-selections.
Choose global minimum for each AE, add p-value cut-off for relative risks.
To view the updated results, click View.
Reduced set of highly-correlated AEs with use of adalimumab, including some on-label events (indicated as Known Drug Reactions).
Select Known AEs
To focus on the on-label events only, select Known Drug Reactions and select View on any of the matrix sub-types.
Absolute counts for the on-label events associated with use of adalimumab.
Normalized per-1000 patients counts for the on-label events associated with use of adalimumab.
Relative risks for the on-label events associated with use of adalimumab.
Quantitative safety signals for the on-label events associated with use of adalimumab.
Visualize
To visualize the results, select a visualization type and choose visualize in the matrix sub-type.
To view per-1000 matrix as a bar chart, select Bar in the Visualization Graph Type and click Visualize under per 1000 patients.