AERSMine: Worked Examples
This page lists all worked example queries for the hypothetical simulations described in the manuscript, and these examples represent a step-by-step approach to reproducing the results. These example queries can be loaded directly by clicking on the example.aers file or can be downloaded by clicking on the download icon , and then loaded using AERSMine’s Explore page. To execute any query, click on Run Analysis on the Explore page.
Lithium
Logical Workflow
Identify AEs correlated with lithium use
Select AEs correlated with lithium use:
.Exclude drugs known to interact with lithium
Exclude known interactions with lithium such as ace inhibitors, coxibs etc.:
.Identify Rx that may mitigate lithium toxicities
Inversely correlated drugs that appear to have a decreased risk of lithium-associated AEs:
.Comparative analysis of therapeutic effects
The differential therapeutic effects across four drug classes – lithium, arbs, beta blockers and antithrombotics.
.Lithium + ARBs
The combination of lithium and arbs appears to show a decreased risk/incidence of lithium-associated neurological and sociological AEs.
.Anti-TNFs
Logical Workflow
Create cohorts
Create mutually exclusive treatment cohorts – aTNFS, methotrexate, glucocorticoids, and aTNFs+glucocorticoids. Specify the indication group (system focus) – patients with anti-TNF responsive rheumatologic conditions, excluding patient with cancer or IBD, Crohn’s, ulcerative colitis.
.Analyze overall and between-group risks
Identify subgroup-specific differential risks across the treatment cohorts.
.Visualize selected AEs
Visualization of selected 18 AEs for subgroup-specific differential risks.
.NSAIDs - Example 1
Create cohorts
Create mutually exclusive cohorts based on the patient indications and drug exposures. Clinical indications-based construction and grouping of patients having arthritis, pain management or hypertension, and reporting the use of propionic acid derivatives, salicylic acid derivatives or cox-2 inhibitors.
.Comparative analysis of differential effects
Identify sub-group specific differential risks across the treatment cohorts.
.Increased risk of AEs due to coxibs use
Increased risk of cardiovascular AEs resulting from use of coxibs.
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NSAIDs - Example 2
Baseline non-aspirin NSAIDs risks
The baseline MI risks of non-aspirin NSAIDs.
.Chronic use of NSAIDs
Chronic use of NSAIDs is prevalent in pain management as in the RA population. Comparative analysis of the RA vs the non-RA population shows the differential NSAIDs-associated MI risks.
.NSAIDS and combinatorial Rx
Comparative analysis of NSAIDs and combinatorial Rx (arbs and ace inhibitors) shows a reduction in MI risks in patients on a combination of NSAIDs and arbs.
.NSAIDs and specific ARBs
A comparative analysis of NSAIDs with various individual arbs such as losartan, telmisartan, olmesartan, candesartan, irbesartan, valsartan, and eprosartan shows the differential effects of MI risks.
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